STRINGSTRING
SFRP1 SFRP1 CNMD CNMD WNT1 WNT1 SORL1 SORL1 SOSTDC1 SOSTDC1 OFD1 OFD1 SKOR1 SKOR1 LOC101973790 LOC101973790 SFRP2 SFRP2 GDF3 GDF3 PIK3CB PIK3CB THBS1 THBS1 GATA3 GATA3 LEMD2 LEMD2 WNT4 WNT4 SMAD6 SMAD6 CHRDL2 CHRDL2 HGS HGS CRIM1 CRIM1 IL12B IL12B CHRDL1 CHRDL1 CASK CASK HHEX HHEX Tob1 Tob1 FBN1 FBN1 SKIL SKIL CHRD CHRD FSTL3 FSTL3 DCN DCN BMPER BMPER RBPMS2 RBPMS2 ATP2B4 ATP2B4 XDH XDH AGTR2 AGTR2 HRG HRG CREB3L1 CREB3L1 PPARG PPARG DLX1 DLX1 FZD1 FZD1 DKK1 DKK1 LEMD3 LEMD3 PPM1A PPM1A IL12A IL12A SPART SPART BAMBI BAMBI SMURF1 SMURF1 SHISA2 SHISA2 SULF2 SULF2 NBL1 NBL1 ADAMTS12 ADAMTS12 TNFAIP6 TNFAIP6 DAND5 DAND5 TWSG1 TWSG1 SMAD7 SMAD7 Spry2 Spry2 EMILIN1 EMILIN1 VWC2 VWC2 AGT AGT Nanog Nanog DAB2IP DAB2IP LOC101974931 LOC101974931 NOG NOG GREM2 GREM2 SULF1 SULF1 SKOR2 SKOR2 PTPN1 PTPN1 CXCL13 CXCL13 SOST SOST SPRY1 SPRY1 WNT5A WNT5A PRDM14 PRDM14 I3NC62_ICTTR I3NC62_ICTTR GREM1 GREM1 TMPRSS6 TMPRSS6 SPRY4 SPRY4 HTRA1 HTRA1 MMRN2 MMRN2 SEMA6A SEMA6A CTDSPL2 CTDSPL2 CFLAR CFLAR NEDD4 NEDD4 SMURF2 SMURF2 PTPRF PTPRF TRIM33 TRIM33 ADGRA2 ADGRA2 PDCD6 PDCD6 APLN APLN LRP2 LRP2 ENSSTOP00000030319 ENSSTOP00000030319 HJV HJV SKI SKI VWC2L VWC2L FUZ FUZ TCF7L2 TCF7L2 SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP1Secreted frizzled related protein 1. (314 aa)
CNMDChondromodulin. (334 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SORL1Sortilin related receptor 1. (2199 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
OFD1OFD1 centriole and centriolar satellite protein. (1027 aa)
SKOR1SKI family transcriptional corepressor 1. (862 aa)
LOC101973790Uncharacterized protein. (311 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
GDF3Growth differentiation factor 3. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
THBS1Thrombospondin 1. (1182 aa)
GATA3GATA binding protein 3. (444 aa)
LEMD2LEM domain containing 2. (500 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CHRDL2Chordin like 2. (424 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
CHRDL1Chordin like 1. (447 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (930 aa)
HHEXHematopoietically expressed homeobox. (272 aa)
Tob1Uncharacterized protein. (345 aa)
FBN1Fibrillin 1. (2736 aa)
SKILSKI like proto-oncogene. (677 aa)
CHRDChordin. (898 aa)
FSTL3Follistatin like 3. (261 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
BMPERBMP binding endothelial regulator. (685 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (206 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
XDHXanthine dehydrogenase. (1300 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
HRGHistidine rich glycoprotein. (531 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
DLX1Distal-less homeobox 1. (255 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (643 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
LEMD3LEM domain containing 3. (907 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
SPARTSpartin. (665 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
SHISA2Shisa family member 2. (295 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
NBL1NBL1, DAN family BMP antagonist. (180 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1560 aa)
TNFAIP6TNF alpha induced protein 6. (276 aa)
DAND5DAN domain BMP antagonist family member 5. (170 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
Spry2Uncharacterized protein. (315 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
NanogHomeobox domain-containing protein. (306 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
LOC101974931Tyrosine-protein phosphatase non-receptor type. (433 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM2Gremlin. (168 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
SKOR2SKI family transcriptional corepressor 2. (837 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (413 aa)
CXCL13C-X-C motif chemokine. (109 aa)
SOSTSclerostin. (212 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PRDM14PR/SET domain 14. (499 aa)
I3NC62_ICTTRUncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (355 aa)
GREM1Gremlin. (184 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (763 aa)
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)
HTRA1HtrA serine peptidase 1. (424 aa)
MMRN2Multimerin 2. (955 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
CTDSPL2CTD small phosphatase like 2. (465 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
NEDD4E3 ubiquitin-protein ligase. (901 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1908 aa)
TRIM33Tripartite motif containing 33. (1028 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1335 aa)
PDCD6Programmed cell death 6. (191 aa)
APLNApelin. (75 aa)
LRP2LDL receptor related protein 2. (4656 aa)
ENSSTOP00000030319Uncharacterized protein. (2101 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
SKISKI proto-oncogene. (730 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
FUZFuzzy planar cell polarity protein. (358 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.