STRINGSTRING
IGF1R IGF1R ADCY5 ADCY5 GRAMD1C GRAMD1C I3LWG0_ICTTR I3LWG0_ICTTR CCND1 CCND1 OPRM1 OPRM1 Brca1 Brca1 ALAD ALAD TYMS TYMS GRIN2B GRIN2B GATA3 GATA3 Cdk4 Cdk4 CYP27B1 CYP27B1 CLDN7 CLDN7 PTGFR PTGFR MSTN MSTN OSBPL7 OSBPL7 CYP1B1 CYP1B1 HMGCS2 HMGCS2 OGG1 OGG1 MAP4K1 MAP4K1 GRIN3A GRIN3A GABBR1 GABBR1 ACACA ACACA RGS2 RGS2 CCL19 CCL19 TSPO TSPO Ahr Ahr UCP1 UCP1 PRKCA PRKCA FOSL1 FOSL1 DRD2 DRD2 PMVK PMVK FDX1 FDX1 MLC1 MLC1 SMAD2 SMAD2 GLRA2 GLRA2 FANCB FANCB SLC10A1 SLC10A1 GRAMD1A GRAMD1A FGFR2 FGFR2 ADCY6 ADCY6 SCNN1G SCNN1G FOXP3 FOXP3 TP53INP1 TP53INP1 TBXAS1 TBXAS1 HNF1A HNF1A EFNA5 EFNA5 KCNC2 KCNC2 ADCY2 ADCY2 MAOB MAOB BLM BLM CLDN18 CLDN18 CRH CRH CSF3 CSF3 CBL CBL EEF1B2 EEF1B2 LARP1 LARP1 I3M6L1_ICTTR I3M6L1_ICTTR Birc2 Birc2 POLB POLB GLRA3 GLRA3 PTRHD1 PTRHD1 ADCY3 ADCY3 DMAP1 DMAP1 CYP7A1 CYP7A1 AKAP8 AKAP8 SETDB1 SETDB1 Eif4ebp1 Eif4ebp1 ADH7 ADH7 FYN FYN ABCB11 ABCB11 AIFM1 AIFM1 BAD BAD Hdac8 Hdac8 SLC2A4 SLC2A4 GNRH1 GNRH1 ADAM15 ADAM15 IREB2 IREB2 CRHBP CRHBP CLDN1 CLDN1 TGFB1 TGFB1 GLB1 GLB1 TNFRSF1A TNFRSF1A NLRP3 NLRP3 PRKAA2 PRKAA2 SPIDR SPIDR TJP1 TJP1 RPL15 RPL15 Rplp0 Rplp0 CASP8 CASP8 SMO SMO ADCYAP1 ADCYAP1 LOC101971868 LOC101971868 EPHA5 EPHA5 CDO1 CDO1 TUFM TUFM GNAI1 GNAI1 SPHK2 SPHK2 PRKCB PRKCB PRKCE PRKCE PPARG PPARG HDAC2 HDAC2 CPT1A CPT1A RECQL5 RECQL5 ADCYAP1R1 ADCYAP1R1 GGH GGH LOC101968303 LOC101968303 XRN1 XRN1 TGFBR1 TGFBR1 LCT LCT MYD88 MYD88 ABCA2 ABCA2 SLIT3 SLIT3 VHL VHL HNRNPD HNRNPD AACS AACS PSMD14 PSMD14 LOC101967926 LOC101967926 ARPC2 ARPC2 LRP6 LRP6 CDA CDA ST6GAL1 ST6GAL1 GOLPH3 GOLPH3 GLRA1 GLRA1 PARP1 PARP1 ADIPOQ ADIPOQ IL2 IL2 CTNNB1 CTNNB1 CA3 CA3 GRAMD1B GRAMD1B CREB1 CREB1 NEFL NEFL Sgk1 Sgk1 LOC101973014 LOC101973014 P2RY4 P2RY4 LEP LEP SHH SHH SIRT1 SIRT1 AVPR1A AVPR1A SDF4 SDF4 TGFBR3 TGFBR3 ARSA ARSA SLC12A3 SLC12A3 PTEN PTEN NR0B2 NR0B2 LOC101956324 LOC101956324 KCNMB1 KCNMB1 BCL2 BCL2 SFRP1 SFRP1 DRD3 DRD3 P2RY6 P2RY6 Ppp1r9b Ppp1r9b CD14 CD14 EHMT2 EHMT2 LOC101960216 LOC101960216 Nanog Nanog LOC101976546 LOC101976546 LOC101959454 LOC101959454 TLR4 TLR4 PTGER2 PTGER2 ADIPOR2 ADIPOR2 CLDN5 CLDN5 CCL21 CCL21 Vcam1 Vcam1 PTGER4 PTGER4 RGS4 RGS4 NPPC NPPC I3N3Z2_ICTTR I3N3Z2_ICTTR ACTC1 ACTC1 SLC6A3 SLC6A3 CCR5 CCR5 NPAS4 NPAS4 INHBB INHBB PTH PTH G6PD G6PD LOC101967640 LOC101967640 TBXA2R TBXA2R Rps6kb1 Rps6kb1 HOXA1 HOXA1 F7 F7 BPIFB2 BPIFB2 FGF19 FGF19 RGS19 RGS19 CASP10 CASP10 I3NC46_ICTTR I3NC46_ICTTR Foxo3 Foxo3 TRH TRH Phb Phb PTGDR PTGDR TH TH CNR1 CNR1 CYBB CYBB I3NE76_ICTTR I3NE76_ICTTR FOSB FOSB DBH DBH DNMT3A DNMT3A I3NFT9_ICTTR I3NFT9_ICTTR GRIN2A GRIN2A LOC106145384 LOC106145384 LRP8 LRP8 CYP8B1 CYP8B1 PRKAA1 PRKAA1 LOC101963381 LOC101963381 ENSSTOP00000024190 ENSSTOP00000024190 GPLD1 GPLD1 ITPR2 ITPR2 Ggt1 Ggt1 CYBA CYBA LOC101962631 LOC101962631 Bcl2l1 Bcl2l1 TGFBR2 TGFBR2 ENSSTOP00000025025 ENSSTOP00000025025 PTGER3 PTGER3 RGS7 RGS7 UNC79 UNC79 ABAT ABAT LOC101977971 LOC101977971 GRIN1 GRIN1 RARA RARA SLC23A2 SLC23A2 Crhr1 Crhr1 HNRNPK HNRNPK ENSSTOP00000026508 ENSSTOP00000026508 EIF4G1 EIF4G1 CHRNB2 CHRNB2 CDK1 CDK1 ENSSTOP00000027930 ENSSTOP00000027930 ENSSTOP00000028389 ENSSTOP00000028389 AKT1 AKT1 ADCY7 ADCY7 JUP JUP NTRK3 NTRK3 H6PD H6PD DAG1 DAG1 LOC101962681 LOC101962681 SREBF1 SREBF1 BAK1 BAK1 LOC101959938 LOC101959938 ATP5F1A ATP5F1A ENSSTOP00000029768 ENSSTOP00000029768 IGF1 IGF1 Inhba Inhba ACTR2 ACTR2 ENSSTOP00000030003 ENSSTOP00000030003 PTK2B PTK2B ADCY8 ADCY8 EPS8 EPS8 PTCH1 PTCH1 SCNN1B SCNN1B NFE2L1 NFE2L1 Got2 Got2 USP46 USP46 ATP2B1 ATP2B1 CCL7 CCL7 LOC101978336 LOC101978336 SLIT2 SLIT2 CDH1 CDH1 MT-ND4 MT-ND4
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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IGF1RTyrosine-protein kinase receptor. (1368 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GRAMD1CGRAM domain containing 1C. (662 aa)
I3LWG0_ICTTRRECA_2 domain-containing protein. (187 aa)
CCND1Cyclin D1. (250 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (326 aa)
Brca1Uncharacterized protein. (353 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)
TYMSUncharacterized protein. (218 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GATA3GATA binding protein 3. (444 aa)
Cdk4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (365 aa)
MSTNMyostatin. (376 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (507 aa)
OGG18-oxoguanine DNA glycosylase. (344 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (821 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
CCL19C-C motif chemokine. (135 aa)
TSPOTranslocator protein. (169 aa)
AhrUncharacterized protein. (848 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PMVKPhosphomevalonate kinase. (192 aa)
FDX1Ferredoxin 1. (184 aa)
MLC1Modulator of VRAC current 1. (388 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
FANCBFA complementation group B. (850 aa)
SLC10A1Solute carrier family 10 member 1. (348 aa)
GRAMD1AGRAM domain containing 1A. (719 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
FOXP3Forkhead box P3. (431 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (533 aa)
HNF1AHNF1 homeobox A. (449 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (186 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (640 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
MAOBAmine oxidase. (520 aa)
BLMBLM RecQ like helicase. (1414 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CRHCorticotropin releasing hormone. (180 aa)
CSF3Colony stimulating factor 3. (210 aa)
CBLCbl proto-oncogene. (870 aa)
EEF1B2Eukaryotic translation elongation factor 1 beta 2; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
LARP1La ribonucleoprotein domain family member 1. (928 aa)
I3M6L1_ICTTRABC transmembrane type-1 domain-containing protein. (528 aa)
Birc2Uncharacterized protein. (611 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (469 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (468 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (685 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1317 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
ADH7Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (374 aa)
FYNTyrosine-protein kinase. (537 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
BADBCL2 associated agonist of cell death. (208 aa)
Hdac8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
ADAM15ADAM metallopeptidase domain 15. (837 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GLB1Beta-galactosidase. (668 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SPIDRScaffold protein involved in DNA repair. (948 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1738 aa)
RPL15Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
Rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
LOC101971868Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
EPHA5EPH receptor A5. (1039 aa)
CDO1Cysteine dioxygenase. (200 aa)
TUFMElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (452 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SPHK2Sphingosine kinase 2. (655 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (480 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
LOC101968303C-C motif chemokine. (93 aa)
XRN15'-3' exoribonuclease 1. (1731 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
LCTLactase. (1928 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ABCA2ATP binding cassette subfamily A member 2. (2414 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
VHLVon Hippel-Lindau tumor suppressor. (182 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (356 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
LOC101967926Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CTNNB1Catenin beta 1. (781 aa)
CA3Carbonic anhydrase 3; Belongs to the alpha-carbonic anhydrase family. (260 aa)
GRAMD1BGRAM domain containing 1B. (723 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (509 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
LOC101973014Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SIRT1Sirtuin 1. (602 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (418 aa)
SDF4Stromal cell derived factor 4. (360 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
ARSAArylsulfatase A. (510 aa)
SLC12A3Solute carrier family 12 member 3. (1004 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
LOC101956324Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (536 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
Ppp1r9bPDZ domain-containing protein. (361 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1254 aa)
LOC1019602163Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
NanogHomeobox domain-containing protein. (306 aa)
LOC101976546PKS_ER domain-containing protein. (375 aa)
LOC1019594543Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
NPPCNatriuretic peptide C. (126 aa)
I3N3Z2_ICTTRUncharacterized protein. (159 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
INHBBInhibin subunit beta B. (336 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
LOC101967640Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HOXA1Homeobox A1. (337 aa)
F7Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)
BPIFB2BPI fold containing family B member 2. (458 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
RGS19Regulator of G protein signaling 19. (231 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
I3NC46_ICTTRNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
Foxo3Forkhead box O3. (673 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
PhbProhibitin. (272 aa)
PTGDRProstaglandin D2 receptor. (355 aa)
THTyrosine hydroxylase. (497 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
DBHDopamine beta-hydroxylase. (620 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
I3NFT9_ICTTRCOesterase domain-containing protein. (179 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
LOC106145384Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (495 aa)
LRP8LDL receptor related protein 8. (940 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
LOC101963381Prohibitin. (297 aa)
ENSSTOP00000024190Protein kinase domain-containing protein. (266 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
Ggt1Uncharacterized protein. (568 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
LOC101962631Prohibitin. (247 aa)
Bcl2l1BH4_2 domain-containing protein. (233 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSSTOP0000002502560S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (286 aa)
PTGER3Prostaglandin E receptor 3. (388 aa)
RGS7Regulator of G protein signaling 7. (480 aa)
UNC79Unc-79 homolog, NALCN channel complex subunit. (2649 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
LOC101977971Aminotran_1_2 domain-containing protein. (393 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
RARARetinoic acid receptor alpha. (462 aa)
SLC23A2Solute carrier family 23 member 2. (650 aa)
Crhr1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (416 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
ENSSTOP00000026508BH4_2 domain-containing protein. (224 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1611 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
JUPJunction plakoglobin. (780 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (818 aa)
DAG1Dystroglycan 1. (895 aa)
LOC101962681Aminotran_1_2 domain-containing protein. (408 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
LOC1019599383Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
ENSSTOP00000029768Aminotran_1_2 domain-containing protein. (365 aa)
IGF1Insulin like growth factor 1. (166 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (839 aa)
PTCH1Patched 1. (1450 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (771 aa)
Got2Aminotran_1_2 domain-containing protein. (274 aa)
USP46Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (366 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
CCL7C-C motif chemokine ligand 7. (96 aa)
LOC10197833660S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (300 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
MT-ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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