(100 nodes) Cellular response to alcohol network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRAMD1B	GRAM domain containing 1B. (723 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
	LOC101956324	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (536 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	LOC101973014	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	Sgk1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
	LOC101978336	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (300 aa)
	CCL7	C-C motif chemokine ligand 7. (96 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (771 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
	PTCH1	Patched 1. (1450 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	Inhba	TGF_BETA_2 domain-containing protein. (133 aa)
	DAG1	Dystroglycan 1. (895 aa)
	JUP	Junction plakoglobin. (780 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ENSSTOP00000027930	Uncharacterized protein. (173 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K. (464 aa)
	SLC23A2	Solute carrier family 23 member 2. (650 aa)
	PTGER3	Prostaglandin E receptor 3. (388 aa)
	ENSSTOP00000025025	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (286 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
	ENSSTOP00000024190	Protein kinase domain-containing protein. (266 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	LRP8	LDL receptor related protein 8. (940 aa)
	LOC106145384	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (495 aa)
	I3NFT9_ICTTR	COesterase domain-containing protein. (179 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
	CYBB	Cytochrome b-245 beta chain. (549 aa)
	PTGDR	Prostaglandin D2 receptor. (355 aa)
	Foxo3	Forkhead box O3. (673 aa)
	I3NC46_ICTTR	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
	HOXA1	Homeobox A1. (337 aa)
	INHBB	Inhibin subunit beta B. (336 aa)
	NPAS4	Neuronal PAS domain protein 4. (802 aa)
	I3N3Z2_ICTTR	Uncharacterized protein. (159 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	GRAMD1C	GRAM domain containing 1C. (662 aa)
	I3LWG0_ICTTR	RECA_2 domain-containing protein. (187 aa)
	Brca1	Uncharacterized protein. (353 aa)
	Rplp0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
	Cdk4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	PTGFR	Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (821 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	Ahr	Uncharacterized protein. (848 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	FDX1	Ferredoxin 1. (184 aa)
	MLC1	Modulator of VRAC current 1. (388 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	FANCB	FA complementation group B. (850 aa)
	GRAMD1A	GRAM domain containing 1A. (719 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	HNF1A	HNF1 homeobox A. (449 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (186 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
	BLM	BLM RecQ like helicase. (1414 aa)
	LARP1	La ribonucleoprotein domain family member 1. (928 aa)
	I3M6L1_ICTTR	ABC transmembrane type-1 domain-containing protein. (528 aa)
	GLRA3	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (469 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	AKAP8	A-kinase anchoring protein 8; Belongs to the AKAP95 family. (685 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	Hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
	ADAM15	ADAM metallopeptidase domain 15. (837 aa)
	IREB2	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	SPIDR	Scaffold protein involved in DNA repair. (948 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1368 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	LOC101971868	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
	EPHA5	EPH receptor A5. (1039 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	SPHK2	Sphingosine kinase 2. (655 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
	XRN1	5'-3' exoribonuclease 1. (1731 aa)
	ARPC2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
	GOLPH3	Golgi phosphoprotein 3. (298 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	Nanog	Homeobox domain-containing protein. (306 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ARPC2	ENSSTOP00000002229	ENSSTOP00000013604	Acetyl-CoA carboxylase alpha.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.475
ACACA	Brca1	ENSSTOP00000002229	ENSSTOP00000000449	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.933
ACACA	ENSSTOP00000027930	ENSSTOP00000002229	ENSSTOP00000027930	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.933
ACACA	I3M6L1_ICTTR	ENSSTOP00000002229	ENSSTOP00000005127	Acetyl-CoA carboxylase alpha.	ABC transmembrane type-1 domain-containing protein.	0.547
ACACA	PRKAA1	ENSSTOP00000002229	ENSSTOP00000024036	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.914
ACACA	PRKAA2	ENSSTOP00000002229	ENSSTOP00000009268	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.903
ADAM15	CDH1	ENSSTOP00000007871	ENSSTOP00000032600	ADAM metallopeptidase domain 15.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.688
ADCY2	ADCY3	ENSSTOP00000004376	ENSSTOP00000005426	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY2	ADCY5	ENSSTOP00000004376	ENSSTOP00000000037	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.939
ADCY2	ADCY6	ENSSTOP00000004376	ENSSTOP00000003745	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.961
ADCY2	ADCY7	ENSSTOP00000004376	ENSSTOP00000028572	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.565
ADCY2	ADCY8	ENSSTOP00000004376	ENSSTOP00000030610	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.777
ADCY2	AKT1	ENSSTOP00000004376	ENSSTOP00000028457	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY2	GNAI1	ENSSTOP00000004376	ENSSTOP00000010973	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.903
ADCY2	PTRHD1	ENSSTOP00000004376	ENSSTOP00000005391	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.520
ADCY3	ADCY2	ENSSTOP00000005426	ENSSTOP00000004376	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY3	ADCY5	ENSSTOP00000005426	ENSSTOP00000000037	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.681
ADCY3	ADCY6	ENSSTOP00000005426	ENSSTOP00000003745	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.854
ADCY3	ADCY7	ENSSTOP00000005426	ENSSTOP00000028572	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.554
ADCY3	ADCY8	ENSSTOP00000005426	ENSSTOP00000030610	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.854