STRINGSTRING
EFNB1 EFNB1 SLC6A3 SLC6A3 KCNA4 KCNA4 P2RY2 P2RY2 SLC1A6 SLC1A6 GPM6A GPM6A P2RY1 P2RY1 SCN11A SCN11A FXYD6 FXYD6 KCNA2 KCNA2 SLC6A11 SLC6A11 CHRM3 CHRM3 ERBB4 ERBB4 I3LX54_ICTTR I3LX54_ICTTR GRIN2B GRIN2B Cntnap4 Cntnap4 PRRT2 PRRT2 CHRNA6 CHRNA6 CDH2 CDH2 GABBR1 GABBR1 FLOT2 FLOT2 EPHA4 EPHA4 DRD2 DRD2 CNTN5 CNTN5 Atp1a3 Atp1a3 GABBR2 GABBR2 CHRM1 CHRM1 SYT11 SYT11 NTNG1 NTNG1 APH1A APH1A GRM8 GRM8 LRFN3 LRFN3 EFNB2 EFNB2 SLC6A1 SLC6A1 GRM3 GRM3 GRIA1 GRIA1 NCSTN NCSTN RGS7BP RGS7BP GRIA3 GRIA3 CACNA1E CACNA1E KCNC4 KCNC4 STX1A STX1A CNTN6 CNTN6 ATP2B4 ATP2B4 SLC6A5 SLC6A5 OPRD1 OPRD1 KCNH1 KCNH1 GRIK5 GRIK5 MARCKSL1 MARCKSL1 GRM7 GRM7 GPC4 GPC4 NPTN NPTN CANX CANX KCNJ3 KCNJ3 CACNA1C CACNA1C CDH10 CDH10 GRIK4 GRIK4 GLRA1 GLRA1 CNTN1 CNTN1 SCN8A SCN8A KCNA1 KCNA1 ATP2B1 ATP2B1 SLC1A2 SLC1A2 ATP2B3 ATP2B3 ADCY8 ADCY8 EFNB3 EFNB3 GABRA5 GABRA5 ADAM23 ADAM23 ATP2B2 ATP2B2 SYT7 SYT7 PTPRD PTPRD NCAM1 NCAM1 GRIK1 GRIK1 CACNA1A CACNA1A CHRNB2 CHRNB2 PTPRS PTPRS KCNJ9 KCNJ9 EPHB2 EPHB2 PSENEN PSENEN P2RX1 P2RX1 GRIA2 GRIA2 ENSSTOP00000025799 ENSSTOP00000025799 CDH9 CDH9 GRIN1 GRIN1 CHRNA4 CHRNA4 P2RY4 P2RY4 CACNA2D1 CACNA2D1 DRD1 DRD1 Cacna1h Cacna1h HTR1A HTR1A SLC6A9 SLC6A9 PSEN1 PSEN1 P2RX3 P2RX3 KCNMA1 KCNMA1 SLC6A7 SLC6A7 CADM3 CADM3 PSEN2 PSEN2 SCN2A SCN2A CHRM2 CHRM2 NECTIN1 NECTIN1 CHRM4 CHRM4 LPAR2 LPAR2 KCNC3 KCNC3 GRIN2A GRIN2A PCDH17 PCDH17 CPLX3 CPLX3 HTR1B HTR1B LOC101967418 LOC101967418 I3NE76_ICTTR I3NE76_ICTTR NTNG2 NTNG2 CNR1 CNR1 KCNC1 KCNC1 KCNA3 KCNA3 DRD4 DRD4 SCN10A SCN10A SCN1A SCN1A LOC101975743 LOC101975743 CADM1 CADM1 ADGRL1 ADGRL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
SLC1A6Amino acid transporter. (564 aa)
GPM6AGlycoprotein M6A. (278 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1764 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (602 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
Cntnap4Uncharacterized protein. (1310 aa)
PRRT2Proline rich transmembrane protein 2. (414 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (920 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
EPHA4EPH receptor A4. (986 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CNTN5Contactin 5. (1099 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (822 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
SYT11Synaptotagmin 11. (419 aa)
NTNG1Netrin G1. (543 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (626 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
NCSTNNicastrin. (709 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (899 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2312 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (506 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (284 aa)
CNTN6Contactin 6. (1028 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
SLC6A5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (797 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1. (962 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (847 aa)
MARCKSL1MARCKS like 1. (178 aa)
GRM7Glutamate metabotropic receptor 7. (629 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
NPTNNeuroplastin. (399 aa)
CANXCalnexin. (589 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
CDH10Cadherin 10; Cadherins are calcium-dependent cell adhesion proteins. (755 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (947 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
CNTN1Contactin 1. (627 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (476 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
SLC1A2Amino acid transporter. (575 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (346 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (545 aa)
ADAM23ADAM metallopeptidase domain 23. (804 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
SYT7Synaptotagmin 7. (688 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1907 aa)
NCAM1Neural cell adhesion molecule 1. (1019 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1855 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
EPHB2EPH receptor B2. (978 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
CDH9Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (617 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1068 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
Cacna1hUncharacterized protein. (2259 aa)
HTR1A5-hydroxytryptamine receptor 1A. (423 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (685 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
SLC6A7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa)
CADM3Cell adhesion molecule 3. (430 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
NECTIN1Nectin cell adhesion molecule 1. (516 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (638 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
PCDH17Protocadherin 17. (1160 aa)
CPLX3Complexin 3. (158 aa)
HTR1B5-hydroxytryptamine receptor 1B. (391 aa)
LOC101967418Uncharacterized protein. (2364 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
NTNG2Netrin G2. (590 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (534 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (495 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1954 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa)
LOC101975743Uncharacterized protein. (1313 aa)
CADM1Cell adhesion molecule 1. (477 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1512 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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