STRINGSTRING
WT1 WT1 SMAD4 SMAD4 EGR1 EGR1 NR3C1 NR3C1 IL10 IL10 GATA2 GATA2 Hif1a Hif1a FOSL1 FOSL1 MRTFA MRTFA TGFB2 TGFB2 BMP4 BMP4 GATA3 GATA3 SMAD6 SMAD6 GNL3 GNL3 BMPR1A BMPR1A SRF SRF TGFBR1 TGFBR1 Srebf2 Srebf2 TNF TNF PPARG PPARG MYOCD MYOCD NFKB1 NFKB1 SMAD1 SMAD1 SMAD3 SMAD3 STAT3 STAT3 ATOH8 ATOH8 SREBF1 SREBF1 ETS1 ETS1 APLN APLN NR1H2 NR1H2 TEAD1 TEAD1 SMARCA4 SMARCA4 I3NFV0_ICTTR I3NFV0_ICTTR Foxo3 Foxo3 JUN JUN SPI1 SPI1 TP53 TP53 PDGFB PDGFB TERT TERT BMP2 BMP2 KLF5 KLF5 CTCF CTCF RELA RELA MRTFB MRTFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WT1WT1 transcription factor. (523 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
IL10Interleukin 10. (178 aa)
GATA2GATA binding protein 2. (481 aa)
Hif1aUncharacterized protein. (821 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
MRTFAMyocardin related transcription factor A. (961 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GATA3GATA binding protein 3. (444 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
GNL3G protein nucleolar 3. (546 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SRFSerum response factor. (505 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
Srebf2BHLH domain-containing protein. (1136 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
MYOCDMyocardin. (894 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
APLNApelin. (75 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1646 aa)
I3NFV0_ICTTRUncharacterized protein. (216 aa)
Foxo3Forkhead box O3. (673 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1079 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
KLF5Kruppel like factor 5. (460 aa)
CTCFCCCTC-binding factor. (727 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MRTFBMyocardin related transcription factor B. (1081 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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