(39 nodes) Regulation of sprouting angiogenesis network (Ictidomys tridecemlineatus)

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second shell of interactors

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PPP1R16B	Protein phosphatase 1 regulatory subunit 16B. (568 aa)
	EPN2	Epsin 2. (648 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	SH2B3	SH2B adaptor protein 3. (429 aa)
	THBS1	Thrombospondin 1. (1182 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	RHOJ	Ras homolog family member J. (214 aa)
	JMJD8	Jumonji domain containing 8. (256 aa)
	IL10	Interleukin 10. (178 aa)
	STARD13	StAR related lipid transfer domain containing 13. (1120 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
	E2F2	E2F transcription factor 2. (432 aa)
	BMPER	BMP binding endothelial regulator. (685 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	TNN	Tenascin N. (1561 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1738 aa)
	FUT1	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (378 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	SYNJ2BP	Synaptojanin 2 binding protein. (145 aa)
	GLUL	Glutamine synthetase. (373 aa)
	KLF4	Kruppel like factor 4. (485 aa)
	SLC39A12	Solute carrier family 39 member 12. (692 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	SHH	Sonic hedgehog signaling molecule. (370 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (663 aa)
	Fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
	I3MVQ8_ICTTR	Uncharacterized protein. (110 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
	I3N2R3_ICTTR	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (376 aa)
	JAK1	Tyrosine-protein kinase. (1142 aa)
	LOC101974597	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (341 aa)
	EPN1	Epsin 1. (576 aa)
	JCAD	Junctional cadherin 5 associated. (1363 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (117 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	TNN	ENSSTOP00000018225	ENSSTOP00000009757	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Tenascin N.	0.460
EPN1	FLT1	ENSSTOP00000020690	ENSSTOP00000018055	Epsin 1.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.473
EPN2	FLT1	ENSSTOP00000026889	ENSSTOP00000018055	Epsin 2.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.473
FGF1	FLT1	ENSSTOP00000021782	ENSSTOP00000018055	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.934
FGF1	Fgf2	ENSSTOP00000021782	ENSSTOP00000015653	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.767
FGF1	PIK3CB	ENSSTOP00000021782	ENSSTOP00000001126	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.578
FGF1	SHH	ENSSTOP00000021782	ENSSTOP00000015201	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Sonic hedgehog signaling molecule.	0.422
FLT1	EPN1	ENSSTOP00000018055	ENSSTOP00000020690	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Epsin 1.	0.473
FLT1	EPN2	ENSSTOP00000018055	ENSSTOP00000026889	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Epsin 2.	0.473
FLT1	FGF1	ENSSTOP00000018055	ENSSTOP00000021782	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.934
FLT1	Fgf2	ENSSTOP00000018055	ENSSTOP00000015653	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.954
FLT1	IL10	ENSSTOP00000018055	ENSSTOP00000005716	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Interleukin 10.	0.610
FLT1	ITGA5	ENSSTOP00000018055	ENSSTOP00000007228	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.487
FLT1	JAK1	ENSSTOP00000018055	ENSSTOP00000019944	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein kinase.	0.553
FLT1	PIK3CB	ENSSTOP00000018055	ENSSTOP00000001126	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.907
FLT1	TNN	ENSSTOP00000018055	ENSSTOP00000009757	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tenascin N.	0.445
FUT1	I3N2R3_ICTTR	ENSSTOP00000011048	ENSSTOP00000018659	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family.	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family.	0.766
FUT1	LOC101974597	ENSSTOP00000011048	ENSSTOP00000020215	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family.	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family.	0.789
Fgf2	FGF1	ENSSTOP00000015653	ENSSTOP00000021782	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.767
Fgf2	FLT1	ENSSTOP00000015653	ENSSTOP00000018055	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.954