(51 nodes) Negative regulation of leukocyte apoptotic process network (Ictidomys tridecemlineatus)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	CCL19	C-C motif chemokine. (135 aa)
	Hif1a	Uncharacterized protein. (821 aa)
	BLM	BLM RecQ like helicase. (1414 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	ORMDL3	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (982 aa)
	CD27	CD27 molecule. (239 aa)
	JAK3	Tyrosine-protein kinase. (1042 aa)
	CD74	CD74 molecule. (279 aa)
	SELENOS	Selenoprotein S. (189 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (667 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (478 aa)
	PIP	Prolactin induced protein. (146 aa)
	CXCR2	C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
	ENSSTOP00000031663	Uncharacterized protein. (187 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	AXL	AXL receptor tyrosine kinase. (887 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	TSC22D3	TSC22 domain family member 3. (200 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (951 aa)
	Foxp1	Fork-head domain-containing protein. (674 aa)
	LOC101972479	A_deaminase domain-containing protein. (338 aa)
	SLC39A10	Solute carrier family 39 member 10. (830 aa)
	GAS6	Growth arrest specific 6. (654 aa)
	BCL10	BCL10 immune signaling adaptor. (153 aa)
	Fcgr2b	Uncharacterized protein. (341 aa)
	KIFAP3	Kinesin associated protein 3. (792 aa)
	CCR5	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
	LOC101972772	A_deaminase domain-containing protein. (352 aa)
	RORC	RAR related orphan receptor C. (518 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	CCL21	C-C motif chemokine ligand 21. (133 aa)
	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (340 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1014 aa)
	PDCD1	Programmed cell death 1. (288 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (1963 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	CCL5	C-C motif chemokine ligand 5. (91 aa)
	ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (182 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (402 aa)
	ARG2	Arginase. (354 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	BCL3	BCL3 transcription coactivator. (440 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	BCL10	ENSSTOP00000029063	ENSSTOP00000020451	AXL receptor tyrosine kinase.	BCL10 immune signaling adaptor.	0.573
AXL	FADD	ENSSTOP00000029063	ENSSTOP00000024623	AXL receptor tyrosine kinase.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.676
AXL	Fcgr2b	ENSSTOP00000029063	ENSSTOP00000020018	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.496
AXL	GAS6	ENSSTOP00000029063	ENSSTOP00000021634	AXL receptor tyrosine kinase.	Growth arrest specific 6.	0.946
AXL	JAK3	ENSSTOP00000029063	ENSSTOP00000006957	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.829
BCL10	AXL	ENSSTOP00000020451	ENSSTOP00000029063	BCL10 immune signaling adaptor.	AXL receptor tyrosine kinase.	0.573
BCL10	BCL3	ENSSTOP00000020451	ENSSTOP00000003883	BCL10 immune signaling adaptor.	BCL3 transcription coactivator.	0.549
BCL10	FADD	ENSSTOP00000020451	ENSSTOP00000024623	BCL10 immune signaling adaptor.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.593
BCL10	MERTK	ENSSTOP00000020451	ENSSTOP00000005610	BCL10 immune signaling adaptor.	MER proto-oncogene, tyrosine kinase.	0.573
BCL10	PRKCQ	ENSSTOP00000020451	ENSSTOP00000018691	BCL10 immune signaling adaptor.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.872
BCL11B	CD74	ENSSTOP00000022911	ENSSTOP00000008077	BAF chromatin remodeling complex subunit BCL11B.	CD74 molecule.	0.404
BCL3	BCL10	ENSSTOP00000003883	ENSSTOP00000020451	BCL3 transcription coactivator.	BCL10 immune signaling adaptor.	0.549
BCL3	CCL5	ENSSTOP00000003883	ENSSTOP00000014170	BCL3 transcription coactivator.	C-C motif chemokine ligand 5.	0.572
BCL3	IL18	ENSSTOP00000003883	ENSSTOP00000015111	BCL3 transcription coactivator.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.574
BCL3	PRKCQ	ENSSTOP00000003883	ENSSTOP00000018691	BCL3 transcription coactivator.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.437
BMP4	GHSR	ENSSTOP00000001023	ENSSTOP00000013942	Bone morphogenetic protein 4.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.542
BMP4	RAG1	ENSSTOP00000001023	ENSSTOP00000017020	Bone morphogenetic protein 4.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.413
CCL19	CCL21	ENSSTOP00000002556	ENSSTOP00000018627	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.869
CCL19	CCL5	ENSSTOP00000002556	ENSSTOP00000014170	C-C motif chemokine.	C-C motif chemokine ligand 5.	0.614
CCL19	CCR5	ENSSTOP00000002556	ENSSTOP00000019243	C-C motif chemokine.	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	0.939