STRINGSTRING
HES1 HES1 PIM1 PIM1 HAND2 HAND2 SOX9 SOX9 RBPJ RBPJ TBX3 TBX3 BMP4 BMP4 BMPR2 BMPR2 TBX5 TBX5 TBX1 TBX1 EYA1 EYA1 Naca Naca MKS1 MKS1 BMP10 BMP10 ISL1 ISL1 LRP6 LRP6 CTNNB1 CTNNB1 SMAD4 SMAD4 SIX1 SIX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES1Hes family bHLH transcription factor 1. (280 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SOX9SRY-box transcription factor 9. (509 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
TBX3T-box transcription factor 3. (744 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX1T-box transcription factor 1. (406 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
NacaNAC-A/B domain-containing protein. (215 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
CTNNB1Catenin beta 1. (781 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SIX1SIX homeobox 1. (284 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.