STRINGSTRING
EIF4G3 EIF4G3 TPST2 TPST2 NR5A1 NR5A1 MSX2 MSX2 CAMK2B CAMK2B ACVR1B ACVR1B I3LWU8_ICTTR I3LWU8_ICTTR KIT KIT WNT4 WNT4 INSR INSR PPP2R1A PPP2R1A BMP4 BMP4 METTL3 METTL3 PRDX4 PRDX4 PDE3A PDE3A PRKACA PRKACA STK11 STK11 Itgb3 Itgb3 OVOL1 OVOL1 C1QBP C1QBP TACR2 TACR2 TPPP2 TPPP2 GPR149 GPR149 NUPR1 NUPR1 HOXD13 HOXD13 LHFPL2 LHFPL2 Zp3 Zp3 STRA8 STRA8 B4GALT1 B4GALT1 RSPO1 RSPO1 RPS6KA2 RPS6KA2 EFCAB1 EFCAB1 SNAI1 SNAI1 TIMP1 TIMP1 LIF LIF I3M7E8_ICTTR I3M7E8_ICTTR PLB1 PLB1 CYP51A1 CYP51A1 RAC1 RAC1 NPR2 NPR2 ZP2 ZP2 PLA2G10 PLA2G10 DDB1 DDB1 TACR3 TACR3 AGO2 AGO2 CFAP69 CFAP69 CITED2 CITED2 MMP12 MMP12 CDC25C CDC25C CALR CALR GNRH1 GNRH1 STXBP1 STXBP1 ASPM ASPM SPINK13 SPINK13 HPGDS HPGDS Apela Apela HYAL3 HYAL3 LFNG LFNG OVGP1 OVGP1 PKDREJ PKDREJ PTGDR2 PTGDR2 FBXO42 FBXO42 ZP1 ZP1 LOC101967418 LOC101967418 CNR1 CNR1 Cdc25b Cdc25b HORMAD1 HORMAD1 LOC101972479 LOC101972479 YTHDF2 YTHDF2 UMODL1 UMODL1 Shb Shb GADD45A GADD45A SERPINF1 SERPINF1 I3NAC7_ICTTR I3NAC7_ICTTR SOX9 SOX9 PRDM14 PRDM14 SIRT2 SIRT2 PDE5A PDE5A FBXO43 FBXO43 SPATA22 SPATA22 WNT5A WNT5A LOC101968224 LOC101968224 LOC101967640 LOC101967640 I3N829_ICTTR I3N829_ICTTR P2RY1 P2RY1 SGO2 SGO2 BNC1 BNC1 Dazl Dazl INHBB INHBB P2RY2 P2RY2 SULF1 SULF1 I3N4N6_ICTTR I3N4N6_ICTTR HOXC4 HOXC4 LOC101972772 LOC101972772 WDR77 WDR77 NPPC NPPC PTGER4 PTGER4 SYDE1 SYDE1 LOC101971097 LOC101971097 MYH9 MYH9 I3N1G5_ICTTR I3N1G5_ICTTR GDF9 GDF9 OXTR OXTR IQCF1 IQCF1 MAPK15 MAPK15 CRISP1 CRISP1 RETN RETN DRD4 DRD4 WT1 WT1 Cfap206 Cfap206 RXRA RXRA GPR3 GPR3 Nanos2 Nanos2 SFRP1 SFRP1 Cacna1h Cacna1h CCR6 CCR6 MOS MOS CHFR CHFR LOC101977702 LOC101977702 IQCF5 IQCF5 AMH AMH EAF2 EAF2 ZFPM2 ZFPM2 AR AR SHH SHH FBXO5 FBXO5 IL18 IL18 CDKN1B CDKN1B I3MSE5_ICTTR I3MSE5_ICTTR DUSP1 DUSP1 PIWIL2 PIWIL2 PLCB1 PLCB1 CTNNB1 CTNNB1 TRIP13 TRIP13 GLRA1 GLRA1 LOC101974752 LOC101974752 GRB14 GRB14 PSMA8 PSMA8 ANXA5 ANXA5 CDC25A CDC25A LOC101967926 LOC101967926 Kif9 Kif9 Gcm1 Gcm1 PRSS37 PRSS37 RGN RGN BAX BAX MEIOC MEIOC NPM2 NPM2 YTHDC2 YTHDC2 NODAL NODAL HDAC2 HDAC2 BMP7 BMP7 CNTD1 CNTD1 RNASE10 RNASE10 Aurka Aurka IGF1R IGF1R HDAC4 HDAC4 TACR1 TACR1 Osm Osm FAM170B FAM170B ASTL ASTL DMRT1 DMRT1 SPINK1 SPINK1 CDC20 CDC20 PLAT PLAT RAD1 RAD1 EDNRB EDNRB STK4 STK4 CCDC36 CCDC36 ACVR1C ACVR1C PLAU PLAU APC APC TCP11 TCP11 ENSSTOP00000030629 ENSSTOP00000030629 LOC101956987 LOC101956987 MFN2 MFN2 Inhba Inhba IGF1 IGF1 ARHGDIB ARHGDIB PRKACB PRKACB Fcgbp Fcgbp YTHDF3 YTHDF3 DHX37 DHX37 FZR1 FZR1 STK3 STK3 ANKRD31 ANKRD31 CIB1 CIB1 ENSSTOP00000026662 ENSSTOP00000026662 JAG1 JAG1 ENSSTOP00000026345 ENSSTOP00000026345 SMURF2 SMURF2 NKX3-1 NKX3-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4G3Eukaryotic translation initiation factor 4 gamma 3. (1712 aa)
TPST2Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (318 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
MSX2Msh homeobox 2. (267 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
I3LWU8_ICTTRUncharacterized protein. (69 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
PRDX4Peroxiredoxin 4. (272 aa)
PDE3APhosphodiesterase. (1145 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
C1QBPComplement C1q binding protein. (281 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
TPPP2Tubulin polymerization promoting protein family member 2. (169 aa)
GPR149G protein-coupled receptor 149. (731 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (81 aa)
HOXD13Homeobox D13. (327 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (228 aa)
Zp3ZP domain-containing protein. (319 aa)
STRA8Stimulated by retinoic acid 8. (372 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
RSPO1R-spondin 1. (236 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
EFCAB1EF-hand calcium binding domain 1. (212 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (206 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
I3M7E8_ICTTRUncharacterized protein. (157 aa)
PLB1Phospholipase B1. (1442 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
RAC1Rac family small GTPase 1. (211 aa)
NPR2Guanylate cyclase. (1047 aa)
ZP2Zona pellucida glycoprotein 2. (695 aa)
PLA2G10Phospholipase A(2). (148 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
TACR3Tachykinin receptor 3. (314 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (862 aa)
CFAP69Cilia and flagella associated protein 69. (936 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
MMP12Matrix metallopeptidase 12. (477 aa)
CDC25CCell division cycle 25C. (427 aa)
CALRCalreticulin. (418 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (586 aa)
ASPMAbnormal spindle microtubule assembly. (3203 aa)
SPINK13Serine peptidase inhibitor, Kazal type 13 (putative). (97 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (204 aa)
ApelaUncharacterized protein. (54 aa)
HYAL3Hyaluronidase. (415 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (320 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (517 aa)
PKDREJPolycystin family receptor for egg jelly. (2034 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (404 aa)
FBXO42F-box protein 42. (717 aa)
ZP1Zona pellucida glycoprotein 1. (619 aa)
LOC101967418Uncharacterized protein. (2364 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
Cdc25bRhodanese domain-containing protein. (572 aa)
HORMAD1HORMA domain containing 1. (364 aa)
LOC101972479A_deaminase domain-containing protein. (338 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (588 aa)
UMODL1Uromodulin like 1. (1350 aa)
ShbSH2 domain-containing protein. (495 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
I3NAC7_ICTTRProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PRDM14PR/SET domain 14. (499 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PDE5APhosphodiesterase. (822 aa)
FBXO43F-box protein 43. (706 aa)
SPATA22Spermatogenesis associated 22. (345 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
LOC101968224Uncharacterized protein. (463 aa)
LOC101967640Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (125 aa)
I3N829_ICTTRRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (225 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SGO2Shugoshin 2. (1230 aa)
BNC1Basonuclin 1. (960 aa)
DazlRRM domain-containing protein. (295 aa)
INHBBInhibin subunit beta B. (336 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
I3N4N6_ICTTRRhodanese domain-containing protein. (465 aa)
HOXC4Homeobox C4. (264 aa)
LOC101972772A_deaminase domain-containing protein. (352 aa)
WDR77WD repeat domain 77. (342 aa)
NPPCNatriuretic peptide C. (126 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
SYDE1Synapse defective Rho GTPase homolog 1. (737 aa)
LOC101971097Uncharacterized protein. (212 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
I3N1G5_ICTTRUncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (1263 aa)
GDF9Growth differentiation factor 9. (449 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
IQCF1IQ motif containing F1. (171 aa)
MAPK15Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
CRISP1Cysteine rich secretory protein 1; Belongs to the CRISP family. (249 aa)
RETNResistin. (109 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
WT1WT1 transcription factor. (523 aa)
Cfap206Uncharacterized protein. (638 aa)
RXRARetinoid X receptor alpha. (461 aa)
GPR3G protein-coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (330 aa)
Nanos2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (130 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
Cacna1hUncharacterized protein. (2259 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (362 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (349 aa)
CHFRCheckpoint with forkhead and ring finger domains. (724 aa)
LOC101977702GCM domain-containing protein. (436 aa)
IQCF5IQ motif containing F5. (148 aa)
AMHAnti-Mullerian hormone. (545 aa)
EAF2ELL associated factor 2. (263 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1149 aa)
ARAndrogen receptor. (884 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
FBXO5F-box protein 5. (450 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
I3MSE5_ICTTRUncharacterized protein. (118 aa)
DUSP1Dual specificity phosphatase 1. (272 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (962 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CTNNB1Catenin beta 1. (781 aa)
TRIP13Thyroid hormone receptor interactor 13. (349 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
LOC101974752Uncharacterized protein. (134 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
PSMA8Proteasome subunit alpha type. (257 aa)
ANXA5Annexin. (321 aa)
CDC25ACell division cycle 25A. (513 aa)
LOC101967926Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
Kif9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (790 aa)
Gcm1GCM domain-containing protein. (382 aa)
PRSS37Serine protease 37. (233 aa)
RGNRegucalcin. (299 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MEIOCMeiosis specific with coiled-coil domain. (960 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (216 aa)
YTHDC2YTH domain containing 2. (1433 aa)
NODALNodal growth differentiation factor. (350 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CNTD1Cyclin N-terminal domain containing 1. (333 aa)
RNASE10Ribonuclease A family member 10 (inactive); Belongs to the pancreatic ribonuclease family. (216 aa)
AurkaProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (363 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
OsmUncharacterized protein. (214 aa)
FAM170BFamily with sequence similarity 170 member B. (303 aa)
ASTLMetalloendopeptidase. (413 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (68 aa)
CDC20Cell division cycle 20. (499 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
RAD1RAD1 checkpoint DNA exonuclease. (279 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
STK4Serine/threonine kinase 4. (488 aa)
CCDC36Coiled-coil domain containing 36. (594 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
PLAUPlasminogen activator, urokinase. (424 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
TCP11T-complex 11. (478 aa)
ENSSTOP00000030629SYCP2_ARLD domain-containing protein. (200 aa)
LOC101956987Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (180 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
IGF1Insulin like growth factor 1. (166 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FcgbpUncharacterized protein. (2584 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
DHX37DEAH-box helicase 37. (1184 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
STK3Serine/threonine kinase 3. (491 aa)
ANKRD31Ankyrin repeat domain 31. (1764 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ENSSTOP00000026662Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (772 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ENSSTOP00000026345Protein kinase domain-containing protein. (386 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
NKX3-1NK3 homeobox 1. (144 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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