(19 nodes) Regulation of cardiac muscle cell differentiation network (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	NRG1	Neuregulin 1. (700 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (334 aa)
	MYOCD	Myocardin. (894 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
	SOX6	SRY-box transcription factor 6. (855 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	Ccnd2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	GREM1	Gremlin. (184 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	ARRB2	Arrestin beta 2. (409 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB2	FZD7	ENSSTOP00000024096	ENSSTOP00000029419	Arrestin beta 2.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.502
ARRB2	GSK3B	ENSSTOP00000024096	ENSSTOP00000023193	Arrestin beta 2.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.503
BMP2	BMP4	ENSSTOP00000018746	ENSSTOP00000001023	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.887
BMP2	GREM1	ENSSTOP00000018746	ENSSTOP00000022065	Bone morphogenetic protein 2.	Gremlin.	0.938
BMP2	SMAD4	ENSSTOP00000018746	ENSSTOP00000016654	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.910
BMP4	BMP2	ENSSTOP00000001023	ENSSTOP00000018746	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.887
BMP4	GREM1	ENSSTOP00000001023	ENSSTOP00000022065	Bone morphogenetic protein 4.	Gremlin.	0.928
BMP4	GSK3B	ENSSTOP00000001023	ENSSTOP00000023193	Bone morphogenetic protein 4.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.441
BMP4	SMAD4	ENSSTOP00000001023	ENSSTOP00000016654	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.921
BMP4	WNT3A	ENSSTOP00000001023	ENSSTOP00000021382	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.448
Ccnd2	GSK3B	ENSSTOP00000016027	ENSSTOP00000023193	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.880
Ccnd2	HDAC3	ENSSTOP00000016027	ENSSTOP00000014542	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.642
DKK1	GSK3B	ENSSTOP00000012136	ENSSTOP00000023193	Dickkopf WNT signaling pathway inhibitor 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.467
DKK1	WNT3A	ENSSTOP00000012136	ENSSTOP00000021382	Dickkopf WNT signaling pathway inhibitor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.897
FZD7	ARRB2	ENSSTOP00000029419	ENSSTOP00000024096	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Arrestin beta 2.	0.502
FZD7	GSK3B	ENSSTOP00000029419	ENSSTOP00000023193	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.598
FZD7	WNT3A	ENSSTOP00000029419	ENSSTOP00000021382	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.915
GREM1	BMP2	ENSSTOP00000022065	ENSSTOP00000018746	Gremlin.	Bone morphogenetic protein 2.	0.938
GREM1	BMP4	ENSSTOP00000022065	ENSSTOP00000001023	Gremlin.	Bone morphogenetic protein 4.	0.928
GSK3B	ARRB2	ENSSTOP00000023193	ENSSTOP00000024096	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Arrestin beta 2.	0.503