STRINGSTRING
WNT3A WNT3A LBH LBH OCIAD1 OCIAD1 NCOA3 NCOA3 EZH2 EZH2 KAT5 KAT5 CCNK CCNK Mtch2 Mtch2 SOX5 SOX5 PRICKLE1 PRICKLE1 ENSSTOP00000026858 ENSSTOP00000026858 JAG1 JAG1 SIRT6 SIRT6 TBX3 TBX3 I3NH73_ICTTR I3NH73_ICTTR CDK13 CDK13 Gata4 Gata4 DICER1 DICER1 GSK3B GSK3B TEAD2 TEAD2 TRIM6 TRIM6 SOX17 SOX17 ESRRB ESRRB HES5 HES5 PTN PTN SOX9 SOX9 HES1 HES1 LTBP3 LTBP3 GATA6 GATA6 ZFP36 ZFP36 PWP1 PWP1 Nanog Nanog RBM24 RBM24 Fgf2 Fgf2 SP7 SP7 NAP1L2 NAP1L2 PRDM4 PRDM4 Cdk12 Cdk12 CDK6 CDK6 EIF2AK2 EIF2AK2 SOX6 SOX6 SMYD5 SMYD5 PDGFRA PDGFRA BBS12 BBS12 PRKDC PRKDC HOXB4 HOXB4 HSPA9 HSPA9 Rest Rest STAT3 STAT3 NELFB NELFB SLC4A11 SLC4A11 KDM4C KDM4C NUDT21 NUDT21 PUS7 PUS7 NKX2-5 NKX2-5 NSUN2 NSUN2 DHX36 DHX36 TBX5 TBX5 KDM3A KDM3A TACSTD2 TACSTD2 TGFB2 TGFB2 NFE2L2 NFE2L2 Hnrnpu Hnrnpu
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LBHLBH regulator of WNT signaling pathway. (107 aa)
OCIAD1OCIA domain containing 1. (247 aa)
NCOA3Nuclear receptor coactivator. (1413 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
Mtch2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
SOX5SRY-box transcription factor 5. (763 aa)
PRICKLE1Prickle planar cell polarity protein 1. (833 aa)
ENSSTOP00000026858Uncharacterized protein. (139 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SIRT6Sirtuin 6. (351 aa)
TBX3T-box transcription factor 3. (744 aa)
I3NH73_ICTTRUncharacterized protein. (248 aa)
CDK13Cyclin dependent kinase 13. (1248 aa)
Gata4GATA-type domain-containing protein. (212 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TEAD2TEA domain transcription factor 2. (452 aa)
TRIM6Tripartite motif containing 6. (469 aa)
SOX17SRY-box transcription factor 17. (415 aa)
ESRRBEstrogen related receptor beta. (454 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
PTNPleiotrophin. (142 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1193 aa)
GATA6GATA binding protein 6. (593 aa)
ZFP36ZFP36 ring finger protein. (324 aa)
PWP1PWP1 homolog, endonuclein. (500 aa)
NanogHomeobox domain-containing protein. (306 aa)
RBM24RNA binding motif protein 24. (236 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
SP7Sp7 transcription factor. (428 aa)
NAP1L2Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. (458 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
Cdk12Protein kinase domain-containing protein. (1489 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
SOX6SRY-box transcription factor 6. (855 aa)
SMYD5SMYD family member 5. (416 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
BBS12Bardet-Biedl syndrome 12. (708 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
HOXB4Homeobox B4. (256 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
RestUncharacterized protein. (328 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
NELFBNegative elongation factor complex member B. (628 aa)
SLC4A11Solute carrier family 4 member 11. (862 aa)
KDM4CLysine demethylase 4C. (1050 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
PUS7Pseudouridine synthase 7. (668 aa)
NKX2-5NK2 homeobox 5. (321 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (758 aa)
DHX36DEAH-box helicase 36. (1000 aa)
TBX5T-box transcription factor 5. (518 aa)
KDM3ALysine demethylase 3A. (1320 aa)
TACSTD2Tumor associated calcium signal transducer 2. (320 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
HnrnpuB30.2/SPRY domain-containing protein. (411 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.