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CHRM4 CHRM4 NECTIN1 NECTIN1 CHRM2 CHRM2 SCN2A SCN2A PSEN2 PSEN2 CADM3 CADM3 SLC6A7 SLC6A7 KCNMA1 KCNMA1 P2RX3 P2RX3 SLC6A9 SLC6A9 GRIN1 GRIN1 CDH9 CDH9 ENSSTOP00000025799 ENSSTOP00000025799 GRIA2 GRIA2 P2RX1 P2RX1 EPHB2 EPHB2 OTOF OTOF KCNJ9 KCNJ9 CLTA CLTA PTPRS PTPRS Septin3 Septin3 CHRNB2 CHRNB2 ERC2 ERC2 CACNA1A CACNA1A GRIK1 GRIK1 NCAM1 NCAM1 APBA1 APBA1 SYT7 SYT7 DNM1 DNM1 ENSSTOP00000029607 ENSSTOP00000029607 ATP2B2 ATP2B2 ADAM23 ADAM23 GABRA5 GABRA5 EFNB3 EFNB3 ADCY8 ADCY8 ATP2B3 ATP2B3 PIP5K1C PIP5K1C SLC1A2 SLC1A2 ATP2B1 ATP2B1 L1CAM L1CAM SCN8A SCN8A SNPH SNPH PTPRD PTPRD ERBB4 ERBB4 I3LX54_ICTTR I3LX54_ICTTR GRIN2B GRIN2B Cntnap4 Cntnap4 STX1B STX1B SNAP91 SNAP91 DGKI DGKI PRRT2 PRRT2 CHRNA6 CHRNA6 GABBR1 GABBR1 EXOC3 EXOC3 EPHA4 EPHA4 FMR1 FMR1 FOSL1 FOSL1 CNTN5 CNTN5 Atp1a3 Atp1a3 GABBR2 GABBR2 CHRM1 CHRM1 CYTH1 CYTH1 SYT11 SYT11 KCNC2 KCNC2 NTNG1 NTNG1 CASK CASK APH1A APH1A GRM8 GRM8 LRFN3 LRFN3 EFNB2 EFNB2 SLC6A1 SLC6A1 KCTD16 KCTD16 GRM3 GRM3 GRIA1 GRIA1 NCSTN NCSTN STXBP1 STXBP1 GRIA3 GRIA3 CACNA1E CACNA1E KCNC4 KCNC4 STX1A STX1A CNTN6 CNTN6 ATP2B4 ATP2B4 SLC6A5 SLC6A5 OPRD1 OPRD1 KCNH1 KCNH1 GRIK5 GRIK5 MARCKSL1 MARCKSL1 GRM7 GRM7 GPC4 GPC4 CANX CANX PCDH19 PCDH19 KCNJ3 KCNJ3 CDH10 CDH10 LOC101970259 LOC101970259 GRIK4 GRIK4 GLRA1 GLRA1 P2RY4 P2RY4 CACNA2D1 CACNA2D1 Cacna1h Cacna1h FER1L6 FER1L6 HTR1A HTR1A DRD4 DRD4 SCN10A SCN10A SCN1A SCN1A ADORA2A ADORA2A LOC101975743 LOC101975743 CADM1 CADM1 ADGRL1 ADGRL1 EFNB1 EFNB1 CADPS2 CADPS2 GRM2 GRM2 KCTD12 KCTD12 SLC6A3 SLC6A3 CLTB CLTB KCNA4 KCNA4 P2RY2 P2RY2 SLC1A6 SLC1A6 GPM6A GPM6A P2RY1 P2RY1 FXYD6 FXYD6 KCNA2 KCNA2 SLC6A11 SLC6A11 HIP1 HIP1 KCNA3 KCNA3 ACHE ACHE CNR1 CNR1 NTNG2 NTNG2 I3NE76_ICTTR I3NE76_ICTTR LOC101967418 LOC101967418 CPLX3 CPLX3 PCDH17 PCDH17 GRIN2A GRIN2A KCNC3 KCNC3 LPAR2 LPAR2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
NECTIN1Nectin cell adhesion molecule 1. (516 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
CADM3Cell adhesion molecule 3. (430 aa)
SLC6A7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (685 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
CDH9Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
EPHB2EPH receptor B2. (978 aa)
OTOFOtoferlin. (1995 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1855 aa)
Septin3Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (355 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (991 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
NCAM1Neural cell adhesion molecule 1. (1019 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (837 aa)
SYT7Synaptotagmin 7. (688 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
ENSSTOP00000029607Uncharacterized protein. (78 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ADAM23ADAM metallopeptidase domain 23. (804 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (545 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (346 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
SLC1A2Amino acid transporter. (575 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
L1CAML1 cell adhesion molecule. (1256 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
SNPHSyntaphilin. (488 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1907 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
Cntnap4Uncharacterized protein. (1310 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (283 aa)
SNAP91Synaptosome associated protein 91. (902 aa)
DGKIDiacylglycerol kinase. (960 aa)
PRRT2Proline rich transmembrane protein 2. (414 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
EXOC3Exocyst complex component 3. (759 aa)
EPHA4EPH receptor A4. (986 aa)
FMR1Fragile X mental retardation 1. (631 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
CNTN5Contactin 5. (1099 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (822 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CYTH1Cytohesin 1. (389 aa)
SYT11Synaptotagmin 11. (419 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (640 aa)
NTNG1Netrin G1. (543 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (930 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (626 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
KCTD16Potassium channel tetramerization domain containing 16. (427 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
NCSTNNicastrin. (709 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (586 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (899 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2312 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (506 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (284 aa)
CNTN6Contactin 6. (1028 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
SLC6A5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (797 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1. (962 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (847 aa)
MARCKSL1MARCKS like 1. (178 aa)
GRM7Glutamate metabotropic receptor 7. (629 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
CANXCalnexin. (589 aa)
PCDH19Protocadherin 19. (1148 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
CDH10Cadherin 10; Cadherins are calcium-dependent cell adhesion proteins. (755 aa)
LOC101970259Uncharacterized protein. (1976 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (947 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1068 aa)
Cacna1hUncharacterized protein. (2259 aa)
FER1L6Fer-1 like family member 6. (1828 aa)
HTR1A5-hydroxytryptamine receptor 1A. (423 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1954 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (417 aa)
LOC101975743Uncharacterized protein. (1313 aa)
CADM1Cell adhesion molecule 1. (477 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1512 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
CADPS2Calcium dependent secretion activator 2. (1234 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
KCTD12Potassium channel tetramerization domain containing 12. (327 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
SLC1A6Amino acid transporter. (564 aa)
GPM6AGlycoprotein M6A. (278 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (602 aa)
HIP1Huntingtin interacting protein 1. (989 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (495 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (614 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
NTNG2Netrin G2. (590 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
LOC101967418Uncharacterized protein. (2364 aa)
CPLX3Complexin 3. (158 aa)
PCDH17Protocadherin 17. (1160 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (638 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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