STRINGSTRING
ADCY5 ADCY5 LOC101968601 LOC101968601 HK1 HK1 CDH1 CDH1 MYOF MYOF L1CAM L1CAM Tmbim7p Tmbim7p SLC1A2 SLC1A2 ATP1A1 ATP1A1 PTCH1 PTCH1 STX2 STX2 NOS3 NOS3 TEK TEK ADCY8 ADCY8 PTK2B PTK2B ENSSTOP00000030319 ENSSTOP00000030319 ATP2B2 ATP2B2 ENSSTOP00000030023 ENSSTOP00000030023 ENSSTOP00000030003 ENSSTOP00000030003 ENSSTOP00000029607 ENSSTOP00000029607 TRPC1 TRPC1 LYN LYN LRP2 LRP2 TRPC4 TRPC4 RFTN2 RFTN2 MOG MOG SMPD2 SMPD2 MYO1C MYO1C LOC106144900 LOC106144900 ENSSTOP00000027615 ENSSTOP00000027615 IQGAP1 IQGAP1 HYAL2 HYAL2 ITPR1 ITPR1 STIM1 STIM1 CTNND1 CTNND1 Gnas Gnas HMOX1 HMOX1 PTPRC PTPRC P2RX1 P2RX1 FXYD1 FXYD1 ENSSTOP00000025794 ENSSTOP00000025794 CD36 CD36 NEDD4 NEDD4 PLPP1 PLPP1 TRPC5 TRPC5 Ahnak Ahnak ENSSTOP00000025283 ENSSTOP00000025283 RGS7 RGS7 P2RX3 P2RX3 CFLAR CFLAR ATP1A2 ATP1A2 KCNMA1 KCNMA1 Pdpn Pdpn ENSSTOP00000024537 ENSSTOP00000024537 CRK CRK ANO1 ANO1 SORBS1 SORBS1 ADTRP ADTRP LRP8 LRP8 RTN4R RTN4R I3NG54_ICTTR I3NG54_ICTTR GSK3B GSK3B Ltb4r Ltb4r CD4 CD4 LOC101967418 LOC101967418 I3NE76_ICTTR I3NE76_ICTTR Cd55 Cd55 PARK7 PARK7 CAV2 CAV2 Plpp3 Plpp3 I3NC62_ICTTR I3NC62_ICTTR RGS19 RGS19 TLR1 TLR1 ERLIN2 ERLIN2 AKAP6 AKAP6 CDH13 CDH13 CEL CEL I3N7W8_ICTTR I3N7W8_ICTTR CSK CSK PTPN11 PTPN11 CAVIN2 CAVIN2 PTGIS PTGIS SLC38A9 SLC38A9 SLC6A3 SLC6A3 SCARB1 SCARB1 EFNB1 EFNB1 PRKN PRKN KCND3 KCND3 MAPT MAPT CD28 CD28 SLC27A1 SLC27A1 NF2 NF2 Hspa1b Hspa1b PECAM1 PECAM1 EMP2 EMP2 TLR6 TLR6 Dmd Dmd PLPP2 PLPP2 CD14 CD14 ASAH2 ASAH2 Cacna1h Cacna1h MS4A15 MS4A15 Ms4a4a Ms4a4a Kcnn4 Kcnn4 CAV1 CAV1 SHH SHH LAMTOR4 LAMTOR4 Ctsd Ctsd LCP2 LCP2 KDR KDR CAVIN3 CAVIN3 NPHS1 NPHS1 GRK2 GRK2 CAVIN4 CAVIN4 PAG1 PAG1 Aqp1 Aqp1 PRNP PRNP CDH15 CDH15 PLD2 PLD2 EPHB1 EPHB1 FURIN FURIN MAPK1 MAPK1 KIF18A KIF18A TGFBR1 TGFBR1 CAV3 CAV3 STAT6 STAT6 ADCYAP1R1 ADCYAP1R1 Hspa1a Hspa1a MYO1A MYO1A PLVAP PLVAP LCK LCK CBLB CBLB CORO1C CORO1C Lipe Lipe IGF1R IGF1R Ehd2 Ehd2 P2RY12 P2RY12 PLLP PLLP TREM2 TREM2 TFPI TFPI TNFRSF1A TNFRSF1A MAL2 MAL2 P2RX7 P2RX7 SLC9A1 SLC9A1 SDC4 SDC4 EDNRB EDNRB SELE SELE SLC2A4 SLC2A4 ANGPT1 ANGPT1 SLC22A6 SLC22A6 Card11 Card11 FYN FYN CD48 CD48 MALL MALL MS4A1 MS4A1 NPC1 NPC1 Birc2 Birc2 BIRC3 BIRC3 RANGRF RANGRF STOM STOM CBL CBL PPT1 PPT1 EEF2 EEF2 HCK HCK BTK BTK ADAM17 ADAM17 ADCY6 ADCY6 BVES BVES MLC1 MLC1 LAMTOR5 LAMTOR5 ITGAM ITGAM ATP7A ATP7A FLOT2 FLOT2 Plscr1 Plscr1 BMPR2 BMPR2 PRKACA PRKACA PLCD1 PLCD1 RET RET RHOQ RHOQ ABCA1 ABCA1 MAPK3 MAPK3 ADD2 ADD2 LRRK2 LRRK2 ERBB4 ERBB4 RFTN1 RFTN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
LOC101968601Uncharacterized protein. (80 aa)
HK1Hexokinase 1. (920 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
MYOFMyoferlin. (1917 aa)
L1CAML1 cell adhesion molecule. (1256 aa)
Tmbim7pUncharacterized protein; Belongs to the BI1 family. (302 aa)
SLC1A2Amino acid transporter. (575 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
PTCH1Patched 1. (1450 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ENSSTOP00000030319Uncharacterized protein. (2101 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ENSSTOP00000030023BTB domain-containing protein; Belongs to the potassium channel family. (530 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
ENSSTOP00000029607Uncharacterized protein. (78 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (748 aa)
LYNTyrosine-protein kinase. (512 aa)
LRP2LDL receptor related protein 2. (4656 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
RFTN2Raftlin family member 2. (499 aa)
MOGMyelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. (244 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (419 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1094 aa)
LOC106144900Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (232 aa)
ENSSTOP00000027615Uncharacterized protein. (247 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
HYAL2Hyaluronidase. (472 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
STIM1Stromal interaction molecule 1. (716 aa)
CTNND1Catenin delta 1. (967 aa)
GnasUncharacterized protein. (244 aa)
HMOX1Heme oxygenase 1. (288 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (68 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
NEDD4E3 ubiquitin-protein ligase. (901 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
AhnakPDZ domain-containing protein. (146 aa)
ENSSTOP00000025283Uncharacterized protein; Belongs to the potassium channel family. (501 aa)
RGS7Regulator of G protein signaling 7. (480 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (394 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
PdpnUncharacterized protein. (163 aa)
ENSSTOP00000024537PDZ domain-containing protein. (112 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
ANO1Anoctamin. (997 aa)
SORBS1Sorbin and SH3 domain containing 1. (931 aa)
ADTRPAndrogen dependent TFPI regulating protein. (219 aa)
LRP8LDL receptor related protein 8. (940 aa)
RTN4RReticulon 4 receptor. (473 aa)
I3NG54_ICTTRUncharacterized protein. (91 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
Ltb4rG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CD4CD4 molecule. (451 aa)
LOC101967418Uncharacterized protein. (2364 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
Cd55Uncharacterized protein. (432 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
I3NC62_ICTTRUncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (355 aa)
RGS19Regulator of G protein signaling 19. (231 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
ERLIN2ER lipid raft associated 2. (339 aa)
AKAP6A-kinase anchoring protein 6. (2318 aa)
CDH13Cadherin 13. (613 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)
I3N7W8_ICTTRUncharacterized protein; Belongs to the TCP-1 chaperonin family. (202 aa)
CSKTyrosine-protein kinase. (450 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
CAVIN2Caveolae associated protein 2. (425 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (414 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (430 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (463 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
MAPTMicrotubule-associated protein. (430 aa)
CD28CD28 molecule. (221 aa)
SLC27A1Solute carrier family 27 member 1. (577 aa)
NF2Neurofibromin 2. (596 aa)
Hspa1bHeat shock protein family A (Hsp70) member 1B. (641 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (740 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
DmdUncharacterized protein. (1255 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
ASAH2Neutral ceramidase. (716 aa)
Cacna1hUncharacterized protein. (2259 aa)
MS4A15Membrane spanning 4-domains A15. (245 aa)
Ms4a4aUncharacterized protein. (228 aa)
Kcnn4CaMBD domain-containing protein. (167 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (99 aa)
CtsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (411 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
CAVIN3Caveolae associated protein 3. (251 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1140 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (690 aa)
CAVIN4Caveolae associated protein 4. (363 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (430 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
PRNPMajor prion protein; Belongs to the prion family. (247 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (778 aa)
PLD2Phospholipase. (933 aa)
EPHB1EPH receptor B1. (984 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (873 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (480 aa)
Hspa1aUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1042 aa)
PLVAPPlasmalemma vesicle associated protein. (445 aa)
LCKTyrosine-protein kinase. (521 aa)
CBLBCbl proto-oncogene B. (985 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
Ehd2Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (105 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
PLLPPlasmolipin. (182 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
TFPITissue factor pathway inhibitor. (301 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
MAL2Mal, T cell differentiation protein 2 (gene/pseudogene). (144 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (176 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SELESelectin E. (495 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ANGPT1Angiopoietin 1. (497 aa)
SLC22A6Solute carrier family 22 member 6. (544 aa)
Card11Uncharacterized protein. (1152 aa)
FYNTyrosine-protein kinase. (537 aa)
CD48CD48 molecule. (254 aa)
MALLMal, T cell differentiation protein like. (153 aa)
MS4A1Membrane spanning 4-domains A1. (295 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
Birc2Uncharacterized protein. (611 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
STOMStomatin. (284 aa)
CBLCbl proto-oncogene. (870 aa)
PPT1Palmitoyl-protein thioesterase 1. (278 aa)
EEF2Eukaryotic translation elongation factor 2. (857 aa)
HCKTyrosine-protein kinase. (502 aa)
BTKTyrosine-protein kinase. (659 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
BVESBlood vessel epicardial substance. (360 aa)
MLC1Modulator of VRAC current 1. (388 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1120 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
Plscr1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (315 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
RHOQRas homolog family member Q. (205 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
ADD2Adducin 2. (724 aa)
LRRK2Leucine rich repeat kinase 2. (2520 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
RFTN1Raftlin, lipid raft linker 1. (571 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (34%) [HD]