STRINGSTRING
NGEF NGEF ERBB4 ERBB4 GRIA4 GRIA4 CAMK2B CAMK2B RTN4 RTN4 I3LX54_ICTTR I3LX54_ICTTR PPP1R1B PPP1R1B GRIN2B GRIN2B GRIP2 GRIP2 CLSTN1 CLSTN1 PRRT2 PRRT2 DLGAP1 DLGAP1 MAPK10 MAPK10 MAGI2 MAGI2 GRIN3A GRIN3A GABBR1 GABBR1 TNIK TNIK DLG2 DLG2 EPHA4 EPHA4 CDH8 CDH8 SYN3 SYN3 GABBR2 GABBR2 ADAM22 ADAM22 CHRM1 CHRM1 CAMK4 CAMK4 Rhoa Rhoa NTNG1 NTNG1 KALRN KALRN FXR2 FXR2 LRFN5 LRFN5 SNAP23 SNAP23 GRM8 GRM8 ARHGAP44 ARHGAP44 STAT3 STAT3 RAC1 RAC1 EFNB2 EFNB2 STX3 STX3 MPP2 MPP2 FYN FYN DLGAP3 DLGAP3 ERC1 ERC1 DNM3 DNM3 SLC6A15 SLC6A15 GRM3 GRM3 GRIA1 GRIA1 HOMER2 HOMER2 STXBP1 STXBP1 CAMK2A CAMK2A NTRK2 NTRK2 FLRT3 FLRT3 GRIA3 GRIA3 CALB1 CALB1 GRID2 GRID2 CACNG4 CACNG4 SLC6A17 SLC6A17 HTT HTT STX1A STX1A GRIK3 GRIK3 GRIK5 GRIK5 ANKS1B ANKS1B GRM7 GRM7 OPHN1 OPHN1 GPC4 GPC4 PPFIA2 PPFIA2 GIT1 GIT1 CDKL5 CDKL5 EPHB1 EPHB1 SYNJ1 SYNJ1 P2RX6 P2RX6 GRIK4 GRIK4 PLCB1 PLCB1 SEMA3F SEMA3F IL1RAPL1 IL1RAPL1 GPC6 GPC6 PPP3CC PPP3CC SLITRK1 SLITRK1 LRRTM1 LRRTM1 LRRTM3 LRRTM3 CACNA2D1 CACNA2D1 CNIH2 CNIH2 DRD3 DRD3 I3MW25_ICTTR I3MW25_ICTTR CBLN1 CBLN1 GABRD GABRD DRD4 DRD4 MAPK8IP2 MAPK8IP2 LRRC4C LRRC4C NRG2 NRG2 I3N0K9_ICTTR I3N0K9_ICTTR SHISA6 SHISA6 ADGRL2 ADGRL2 LRRTM4 LRRTM4 Lrrc4b Lrrc4b ADORA2A ADORA2A LOC101959358 LOC101959358 CADM1 CADM1 FXR1 FXR1 ADGRL1 ADGRL1 EFNB1 EFNB1 NPTX1 NPTX1 DLGAP4 DLGAP4 LRRTM2 LRRTM2 CPLX2 CPLX2 GSG1L GSG1L SHANK3 SHANK3 SLC1A6 SLC1A6 GRIN2D GRIN2D P2RY1 P2RY1 PFN1 PFN1 PCDH8 PCDH8 WNT5A WNT5A PTPRZ1 PTPRZ1 KCNA3 KCNA3 IQSEC1 IQSEC1 CNR1 CNR1 ARC ARC GSK3B GSK3B GRIN2A GRIN2A CHRM4 CHRM4 GHRL GHRL CHRM2 CHRM2 RTN4R RTN4R SCN2A SCN2A DLG3 DLG3 CTBP2 CTBP2 ADGRL3 ADGRL3 DLG4 DLG4 SLC6A7 SLC6A7 KCNMA1 KCNMA1 CTTN CTTN RGS7 RGS7 GRIN1 GRIN1 CDH9 CDH9 ENSSTOP00000025799 ENSSTOP00000025799 GRIA2 GRIA2 MECP2 MECP2 EPHB2 EPHB2 LGI1 LGI1 CACNG2 CACNG2 ENSSTOP00000026667 ENSSTOP00000026667 DLG1 DLG1 PTPRS PTPRS SHISA9 SHISA9 SHISA7 SHISA7 CACNA1A CACNA1A CLSTN3 CLSTN3 SNAP47 SNAP47 Nlgn4x Nlgn4x NTRK3 NTRK3 GRIP1 GRIP1 DBN1 DBN1 GRIK1 GRIK1 NPTX2 NPTX2 NCAM1 NCAM1 PTPRD PTPRD SYT7 SYT7 AGRN AGRN LRRC7 LRRC7 NETO1 NETO1 ATP2B2 ATP2B2 ADAM23 ADAM23 PTK2B PTK2B EFNB3 EFNB3 Nrn1 Nrn1 TENM2 TENM2 UNC13A UNC13A IQSEC2 IQSEC2 ENSSTOP00000032175 ENSSTOP00000032175 MTOR MTOR BAIAP2 BAIAP2 NRG1 NRG1 SCN8A SCN8A SYNGAP1 SYNGAP1 CACNG3 CACNG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NGEFNeuronal guanine nucleotide exchange factor. (707 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
RTN4Reticulon. (1177 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GRIP2Glutamate receptor interacting protein 2. (949 aa)
CLSTN1Calsyntenin 1. (958 aa)
PRRT2Proline rich transmembrane protein 2. (414 aa)
DLGAP1DLG associated protein 1. (979 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1188 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
DLG2Discs large MAGUK scaffold protein 2. (870 aa)
EPHA4EPH receptor A4. (986 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (679 aa)
SYN3Synapsin III. (579 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (822 aa)
ADAM22ADAM metallopeptidase domain 22. (894 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
RhoaRas homolog family member A. (193 aa)
NTNG1Netrin G1. (543 aa)
KALRNKalirin RhoGEF kinase. (2951 aa)
FXR2FMR1 autosomal homolog 2. (672 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (719 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
ARHGAP44Rho GTPase activating protein 44. (812 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
RAC1Rac family small GTPase 1. (211 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (287 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (569 aa)
FYNTyrosine-protein kinase. (537 aa)
DLGAP3DLG associated protein 3. (979 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
SLC6A15Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (732 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
HOMER2Homer scaffold protein 2. (354 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (586 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
NTRK2Tyrosine-protein kinase receptor. (821 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (899 aa)
CALB1Calbindin 1. (261 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (922 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (301 aa)
SLC6A17Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (727 aa)
HTTHuntingtin. (3114 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (284 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (919 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (847 aa)
ANKS1BAnkyrin repeat and sterile alpha motif domain containing 1B. (1260 aa)
GRM7Glutamate metabotropic receptor 7. (629 aa)
OPHN1Oligophrenin 1. (718 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
PPFIA2PTPRF interacting protein alpha 2. (1174 aa)
GIT1GIT ArfGAP 1. (773 aa)
CDKL5Cyclin dependent kinase like 5. (960 aa)
EPHB1EPH receptor B1. (984 aa)
SYNJ1Synaptojanin 1. (1609 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (377 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (947 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (437 aa)
GPC6Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (565 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (521 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1068 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
I3MW25_ICTTRUncharacterized protein. (144 aa)
CBLN1Cerebellin 1 precursor. (183 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (820 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
NRG2Neuregulin 2. (767 aa)
I3N0K9_ICTTRUncharacterized protein. (198 aa)
SHISA6Shisa family member 6. (469 aa)
ADGRL2Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family. (1487 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (591 aa)
Lrrc4bLRRNT domain-containing protein. (232 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (417 aa)
LOC101959358Uncharacterized protein. (193 aa)
CADM1Cell adhesion molecule 1. (477 aa)
FXR1FMR1 autosomal homolog 1. (677 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1512 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
DLGAP4DLG associated protein 4. (992 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
CPLX2Complexin 2. (134 aa)
GSG1LGSG1 like. (215 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1645 aa)
SLC1A6Amino acid transporter. (564 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1394 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PCDH8Protocadherin 8. (1070 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2277 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (495 aa)
IQSEC1IQ motif and Sec7 domain 1. (941 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
ARCActivity regulated cytoskeleton associated protein. (391 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
RTN4RReticulon 4 receptor. (473 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (867 aa)
CTBP2C-terminal binding protein 2. (985 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1478 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
SLC6A7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
CTTNCortactin. (549 aa)
RGS7Regulator of G protein signaling 7. (480 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
CDH9Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
EPHB2EPH receptor B2. (978 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ENSSTOP00000026667Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1855 aa)
SHISA9Shisa family member 9. (402 aa)
SHISA7Shisa family member 7. (563 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
CLSTN3Calsyntenin 3. (957 aa)
SNAP47Synaptosome associated protein 47. (447 aa)
Nlgn4xCOesterase domain-containing protein. (817 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
GRIP1Glutamate receptor interacting protein 1. (1128 aa)
DBN1Drebrin 1. (679 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
NPTX2Neuronal pentraxin 2. (423 aa)
NCAM1Neural cell adhesion molecule 1. (1019 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1907 aa)
SYT7Synaptotagmin 7. (688 aa)
AGRNAgrin. (1964 aa)
LRRC7Leucine rich repeat containing 7. (1573 aa)
NETO1Neuropilin and tolloid like 1. (540 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ADAM23ADAM metallopeptidase domain 23. (804 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (346 aa)
Nrn1Uncharacterized protein. (176 aa)
TENM2Teneurin transmembrane protein 2. (2765 aa)
UNC13AUnc-13 homolog A. (1732 aa)
IQSEC2IQ motif and Sec7 domain 2. (1488 aa)
ENSSTOP00000032175Uncharacterized protein. (123 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
NRG1Neuregulin 1. (700 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1336 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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