STRINGSTRING
PNLIP PNLIP DENND5A DENND5A ALOX15B ALOX15B ALOXE3 ALOXE3 Pkd1l1 Pkd1l1 ALOX12 ALOX12 DENND5B DENND5B Pkd1l2 Pkd1l2 PNLIPRP1 PNLIPRP1 PNLIPRP2 PNLIPRP2 LOC101963157 LOC101963157 PKD1 PKD1 LIPG LIPG ALOX5 ALOX5 LOXHD1 LOXHD1 ALOX15 ALOX15 ALOX12B ALOX12B PKDREJ PKDREJ LIPC LIPC LPL LPL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PNLIPPancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius. (465 aa)
DENND5ADENN domain containing 5A. (1288 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
Pkd1l1Uncharacterized protein. (2043 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
DENND5BDENN domain containing 5B. (1170 aa)
Pkd1l2Uncharacterized protein. (2457 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (481 aa)
LOC101963157Uncharacterized protein. (662 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4252 aa)
LIPGLipase G, endothelial type. (500 aa)
ALOX5Arachidonate 5-lipoxygenase. (663 aa)
LOXHD1Lipoxygenase homology domains 1. (2017 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (701 aa)
PKDREJPolycystin family receptor for egg jelly. (2034 aa)
LIPCLipase C, hepatic type. (463 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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