(37 nodes) Transforming growth factor-beta, C-terminal network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AMH	Anti-Mullerian hormone. (545 aa)
	PSPN	Persephin. (158 aa)
	BMP6	Bone morphogenetic protein 6. (507 aa)
	GDF9	Growth differentiation factor 9. (449 aa)
	GDF6	Growth differentiation factor 6. (460 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	GDF7	Growth differentiation factor 7. (445 aa)
	GDF15	Growth differentiation factor 15. (329 aa)
	GDNF	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
	INHBB	Inhibin subunit beta B. (336 aa)
	INHBE	Inhibin subunit beta E. (349 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	ARTN	Artemin. (226 aa)
	GDF2	Growth differentiation factor 2. (429 aa)
	INHBC	Inhibin subunit beta C. (352 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	GDF5	Growth differentiation factor 5. (495 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
	LOC101961346	Left-right determination factor. (363 aa)
	GDF11	Growth differentiation factor 11. (387 aa)
	Gdf1	TGF_BETA_2 domain-containing protein. (373 aa)
	Inhba	TGF_BETA_2 domain-containing protein. (133 aa)
	ENSSTOP00000030884	TGF_BETA_2 domain-containing protein. (272 aa)
	LOC101962293	Left-right determination factor. (367 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	Bmp8b	TGF_BETA_2 domain-containing protein. (252 aa)
	MSTN	Myostatin. (376 aa)
	GDF3	Growth differentiation factor 3. (360 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	LOC101967701	TGF_BETA_2 domain-containing protein. (397 aa)
	NRTN	Neurturin. (197 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	BMP10	Bone morphogenetic protein 10. (422 aa)
	BMP3	Bone morphogenetic protein 3. (487 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	NODAL	Nodal growth differentiation factor. (350 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	GDF9	ENSSTOP00000015446	ENSSTOP00000018202	Anti-Mullerian hormone.	Growth differentiation factor 9.	0.556
AMH	LOC101967701	ENSSTOP00000015446	ENSSTOP00000006886	Anti-Mullerian hormone.	TGF_BETA_2 domain-containing protein.	0.565
ARTN	GDNF	ENSSTOP00000022501	ENSSTOP00000019471	Artemin.	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	0.489
ARTN	NRTN	ENSSTOP00000022501	ENSSTOP00000008556	Artemin.	Neurturin.	0.466
ARTN	PSPN	ENSSTOP00000022501	ENSSTOP00000017331	Artemin.	Persephin.	0.408
BMP10	BMP2	ENSSTOP00000009290	ENSSTOP00000018746	Bone morphogenetic protein 10.	Bone morphogenetic protein 2.	0.509
BMP10	BMP4	ENSSTOP00000009290	ENSSTOP00000001023	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.480
BMP10	BMP5	ENSSTOP00000009290	ENSSTOP00000002171	Bone morphogenetic protein 10.	Bone morphogenetic protein 5.	0.505
BMP10	BMP6	ENSSTOP00000009290	ENSSTOP00000017540	Bone morphogenetic protein 10.	Bone morphogenetic protein 6.	0.432
BMP10	BMP7	ENSSTOP00000009290	ENSSTOP00000011380	Bone morphogenetic protein 10.	Bone morphogenetic protein 7.	0.463
BMP10	GDF15	ENSSTOP00000009290	ENSSTOP00000019199	Bone morphogenetic protein 10.	Growth differentiation factor 15.	0.568
BMP10	GDF2	ENSSTOP00000009290	ENSSTOP00000022676	Bone morphogenetic protein 10.	Growth differentiation factor 2.	0.771
BMP10	GDF5	ENSSTOP00000009290	ENSSTOP00000022883	Bone morphogenetic protein 10.	Growth differentiation factor 5.	0.479
BMP10	GDF6	ENSSTOP00000009290	ENSSTOP00000018656	Bone morphogenetic protein 10.	Growth differentiation factor 6.	0.472
BMP2	BMP10	ENSSTOP00000018746	ENSSTOP00000009290	Bone morphogenetic protein 2.	Bone morphogenetic protein 10.	0.509
BMP2	BMP4	ENSSTOP00000018746	ENSSTOP00000001023	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.887
BMP2	BMP5	ENSSTOP00000018746	ENSSTOP00000002171	Bone morphogenetic protein 2.	Bone morphogenetic protein 5.	0.788
BMP2	BMP6	ENSSTOP00000018746	ENSSTOP00000017540	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.919
BMP2	BMP7	ENSSTOP00000018746	ENSSTOP00000011380	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.893
BMP2	Bmp8b	ENSSTOP00000018746	ENSSTOP00000031585	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.575