(17 nodes) Furin-like repeat network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RSPO2	R-spondin 2. (243 aa)
	CRELD1	Cysteine rich with EGF like domains 1. (420 aa)
	RSPO3	R-spondin 3. (275 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1248 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (901 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1880 aa)
	RSPO4	R-spondin 4. (233 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	INSR	Tyrosine-protein kinase receptor. (1359 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1256 aa)
	RSPO1	R-spondin 1. (236 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (355 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (3927 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1368 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	INSRR	Tyrosine-protein kinase receptor. (1279 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSSTOP00000006038	ENSSTOP00000003374	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSSTOP00000006038	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.995
EGFR	ERBB4	ENSSTOP00000006038	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.986
EGFR	IGF1R	ENSSTOP00000006038	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.959
EGFR	INSR	ENSSTOP00000006038	ENSSTOP00000000977	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.893
EGFR	INSRR	ENSSTOP00000006038	ENSSTOP00000018697	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.830
ERBB2	EGFR	ENSSTOP00000003374	ENSSTOP00000006038	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	ERBB3	ENSSTOP00000003374	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.997
ERBB2	ERBB4	ENSSTOP00000003374	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.992
ERBB2	IGF1R	ENSSTOP00000003374	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.969
ERBB2	INSR	ENSSTOP00000003374	ENSSTOP00000000977	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.913
ERBB2	INSRR	ENSSTOP00000003374	ENSSTOP00000018697	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.860
ERBB3	EGFR	ENSSTOP00000023609	ENSSTOP00000006038	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.995
ERBB3	ERBB2	ENSSTOP00000023609	ENSSTOP00000003374	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.997
ERBB3	ERBB4	ENSSTOP00000023609	ENSSTOP00000000168	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.960
ERBB3	IGF1R	ENSSTOP00000023609	ENSSTOP00000010241	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.819
ERBB3	INSR	ENSSTOP00000023609	ENSSTOP00000000977	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.636
ERBB3	INSRR	ENSSTOP00000023609	ENSSTOP00000018697	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.636
ERBB4	EGFR	ENSSTOP00000000168	ENSSTOP00000006038	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.986
ERBB4	ERBB2	ENSSTOP00000000168	ENSSTOP00000003374	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.992