(92 nodes) Tyrosine-protein kinase, active site network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGFR4	Fibroblast growth factor receptor. (801 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	RYK	Receptor like tyrosine kinase. (475 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1368 aa)
	EPHA5	EPH receptor A5. (1039 aa)
	MATK	Tyrosine-protein kinase. (466 aa)
	LCK	Tyrosine-protein kinase. (521 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	EPHB1	EPH receptor B1. (984 aa)
	EPHA3	EPH receptor A3. (984 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (890 aa)
	NTRK3	Tyrosine-protein kinase receptor. (864 aa)
	EPHA7	EPH receptor A7. (998 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	JAK1	Tyrosine-protein kinase. (1142 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1380 aa)
	INSRR	Tyrosine-protein kinase receptor. (1279 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
	LMTK3	Lemur tyrosine kinase 3. (1172 aa)
	TESK1	Testis associated actin remodelling kinase 1. (587 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
	PLK4	Polo like kinase 4. (909 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
	TXK	Tyrosine-protein kinase. (526 aa)
	LOC101955809	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
	FGR	Tyrosine-protein kinase. (527 aa)
	TP53RK	TP53 regulating kinase. (246 aa)
	PEAK1	Pseudopodium enriched atypical kinase 1. (1673 aa)
	SRC	Tyrosine-protein kinase. (541 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	NEK10	NIMA related kinase 10. (1116 aa)
	AXL	AXL receptor tyrosine kinase. (887 aa)
	HCK	Tyrosine-protein kinase. (502 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	MST1R	Macrophage stimulating 1 receptor. (1382 aa)
	FGFR2	Fibroblast growth factor receptor. (823 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1256 aa)
	TYK2	Tyrosine-protein kinase. (1194 aa)
	EPHA2	EPH receptor A2. (923 aa)
	PRAG1	PEAK1 related, kinase-activating pseudokinase 1. (1373 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	NTRK2	Tyrosine-protein kinase receptor. (821 aa)
	LTK	Tyrosine-protein kinase receptor. (576 aa)
	NTRK1	Tyrosine-protein kinase receptor. (799 aa)
	SRMS	Tyrosine-protein kinase. (534 aa)
	PTK6	Tyrosine-protein kinase. (450 aa)
	JAK3	Tyrosine-protein kinase. (1042 aa)
	TNK1	Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (662 aa)
	ALK	Tyrosine-protein kinase receptor. (1612 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (910 aa)
	INSR	Tyrosine-protein kinase receptor. (1359 aa)
	STYK1	Serine/threonine/tyrosine kinase 1. (328 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	EPHB4	EPH receptor B4. (987 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (956 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (884 aa)
	TEC	Tyrosine-protein kinase. (630 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (915 aa)
	FGFR1	Fibroblast growth factor receptor. (822 aa)
	EPHA1	EPH receptor A1. (978 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
	ABL2	Tyrosine-protein kinase. (1142 aa)
	EPHA6	EPH receptor A6. (1128 aa)
	ROS1	Tyrosine-protein kinase receptor. (2333 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	LMTK2	Lemur tyrosine kinase 2. (1485 aa)
	EPHB2	EPH receptor B2. (978 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	PTK2B	Protein tyrosine kinase 2 beta. (968 aa)
	EPHB3	EPH receptor B3. (996 aa)
	EPHA8	EPH receptor A8. (1006 aa)
	FRK	Tyrosine-protein kinase. (511 aa)
	TESK2	Testis associated actin remodelling kinase 2. (549 aa)
	ZAP70	Tyrosine-protein kinase. (608 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (855 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
	EPHA4	EPH receptor A4. (986 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	BMX	Tyrosine-protein kinase. (655 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (982 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
	TNK2	Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1055 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EGFR	ENSSTOP00000023658	ENSSTOP00000006038	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.506
ABL1	EPHA1	ENSSTOP00000023658	ENSSTOP00000004592	Tyrosine-protein kinase.	EPH receptor A1.	0.819
ABL1	EPHA2	ENSSTOP00000023658	ENSSTOP00000002767	Tyrosine-protein kinase.	EPH receptor A2.	0.820
ABL1	EPHA3	ENSSTOP00000023658	ENSSTOP00000013344	Tyrosine-protein kinase.	EPH receptor A3.	0.808
ABL1	EPHA4	ENSSTOP00000023658	ENSSTOP00000002692	Tyrosine-protein kinase.	EPH receptor A4.	0.809
ABL1	EPHA5	ENSSTOP00000023658	ENSSTOP00000010471	Tyrosine-protein kinase.	EPH receptor A5.	0.812
ABL1	EPHA6	ENSSTOP00000023658	ENSSTOP00000020881	Tyrosine-protein kinase.	EPH receptor A6.	0.789
ABL1	EPHA7	ENSSTOP00000023658	ENSSTOP00000028023	Tyrosine-protein kinase.	EPH receptor A7.	0.788
ABL1	EPHA8	ENSSTOP00000023658	ENSSTOP00000029794	Tyrosine-protein kinase.	EPH receptor A8.	0.809
ABL1	EPHB1	ENSSTOP00000023658	ENSSTOP00000013324	Tyrosine-protein kinase.	EPH receptor B1.	0.820
ABL1	EPHB2	ENSSTOP00000023658	ENSSTOP00000026283	Tyrosine-protein kinase.	EPH receptor B2.	0.828
ABL1	EPHB3	ENSSTOP00000023658	ENSSTOP00000029962	Tyrosine-protein kinase.	EPH receptor B3.	0.824
ABL1	EPHB4	ENSSTOP00000023658	ENSSTOP00000026645	Tyrosine-protein kinase.	EPH receptor B4.	0.833
ABL1	ERBB2	ENSSTOP00000023658	ENSSTOP00000003374	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.479
ABL1	ERBB4	ENSSTOP00000023658	ENSSTOP00000000168	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.479
ABL1	FGR	ENSSTOP00000023658	ENSSTOP00000015995	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.407
ABL1	FLT3	ENSSTOP00000023658	ENSSTOP00000002636	Tyrosine-protein kinase.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.599
ABL1	MUSK	ENSSTOP00000023658	ENSSTOP00000026918	Tyrosine-protein kinase.	Muscle associated receptor tyrosine kinase.	0.567
ABL1	NTRK1	ENSSTOP00000023658	ENSSTOP00000007027	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.826
ABL1	NTRK2	ENSSTOP00000023658	ENSSTOP00000008008	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.825