(72 nodes) Protein-tyrosine phosphatase, active site network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPRD	Protein tyrosine phosphatase receptor type D. (1907 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1216 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1197 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1855 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1186 aa)
	PTPN20	Protein tyrosine phosphatase non-receptor type 20. (357 aa)
	PTPRM	Protein tyrosine phosphatase receptor type M. (1507 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1180 aa)
	MTM1	Myotubularin 1. (603 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1908 aa)
	PTPRU	Protein tyrosine phosphatase receptor type U. (1444 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (882 aa)
	DUSP8	Dual specificity phosphatase 8. (623 aa)
	DUSP2	Dual specificity phosphatase 2; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (230 aa)
	DUSP16	Dual specificity phosphatase 16. (660 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
	LOC101954438	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (214 aa)
	PTPRA	Receptor-type tyrosine-protein phosphatase alpha. (813 aa)
	DUPD1	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (216 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (2277 aa)
	PTPN12	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (778 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (413 aa)
	PTPN7	Protein tyrosine phosphatase non-receptor type 7. (362 aa)
	LOC101954721	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
	LOC101974931	Tyrosine-protein phosphatase non-receptor type. (433 aa)
	PTPMT1	Protein tyrosine phosphatase mitochondrial 1. (201 aa)
	CDC14B	Uncharacterized protein. (450 aa)
	DUSP11	Dual specificity phosphatase 11. (332 aa)
	LOC101955481	TYR_PHOSPHATASE_2 domain-containing protein. (173 aa)
	PTPDC1	Protein tyrosine phosphatase domain containing 1. (752 aa)
	MTMR1	Myotubularin related protein 1. (665 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	SSH1	Slingshot protein phosphatase 1. (1016 aa)
	PTPRN	Protein tyrosine phosphatase receptor type N. (979 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	MTMR7	Myotubularin related protein 7. (661 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (754 aa)
	Dusp3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
	PTPN21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1108 aa)
	PTPRR	Protein tyrosine phosphatase receptor type R. (412 aa)
	PTPRB	Protein tyrosine phosphatase receptor type B. (1998 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (1392 aa)
	PTPRT	Protein tyrosine phosphatase receptor type T. (1421 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (389 aa)
	MTMR3	Myotubularin related protein 3. (1006 aa)
	SSH3	Slingshot protein phosphatase 3. (648 aa)
	MTMR2	Myotubularin related protein 2. (643 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	MTMR4	Myotubularin related protein 4. (1208 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	MTMR8	Myotubularin related protein 8. (716 aa)
	Ptprh	Uncharacterized protein. (455 aa)
	DUSP5	Dual specificity phosphatase 5; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (260 aa)
	DUSP15	Dual specificity phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (238 aa)
	CDC14A	Cell division cycle 14A. (612 aa)
	RNGTT	Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (597 aa)
	Dusp21	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (189 aa)
	PTPRE	Receptor-type tyrosine-protein phosphatase. (711 aa)
	PTPN9	Protein tyrosine phosphatase non-receptor type 9. (593 aa)
	DUSP13	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
	MTMR6	Myotubularin related protein 6. (621 aa)
	DUSP14	Dual specificity phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (198 aa)
	Dusp23	TYR_PHOSPHATASE_2 domain-containing protein. (122 aa)
	MTMR14	Myotubularin related protein 14. (643 aa)
	PTPN5	Protein tyrosine phosphatase non-receptor type 5. (538 aa)
	PTPN23	Protein tyrosine phosphatase non-receptor type 23. (1639 aa)
	PTPN4	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
	DUSP1	Dual specificity phosphatase 1. (272 aa)
	SSH2	Slingshot protein phosphatase 2. (1423 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	Ptprg	Uncharacterized protein. (676 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC14A	CDC14B	ENSSTOP00000018133	ENSSTOP00000017677	Cell division cycle 14A.	Uncharacterized protein.	0.842
CDC14B	CDC14A	ENSSTOP00000017677	ENSSTOP00000018133	Uncharacterized protein.	Cell division cycle 14A.	0.842
DUPD1	PTPN20	ENSSTOP00000021008	ENSSTOP00000027113	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 20.	0.427
DUPD1	PTPN5	ENSSTOP00000021008	ENSSTOP00000000860	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.672
DUPD1	PTPN7	ENSSTOP00000021008	ENSSTOP00000020011	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 7.	0.574
DUPD1	PTPRR	ENSSTOP00000021008	ENSSTOP00000011775	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase receptor type R.	0.574
DUSP1	PTPN20	ENSSTOP00000014874	ENSSTOP00000027113	Dual specificity phosphatase 1.	Protein tyrosine phosphatase non-receptor type 20.	0.427
DUSP1	PTPN5	ENSSTOP00000014874	ENSSTOP00000000860	Dual specificity phosphatase 1.	Protein tyrosine phosphatase non-receptor type 5.	0.489
DUSP1	PTPN7	ENSSTOP00000014874	ENSSTOP00000020011	Dual specificity phosphatase 1.	Protein tyrosine phosphatase non-receptor type 7.	0.433
DUSP1	PTPRR	ENSSTOP00000014874	ENSSTOP00000011775	Dual specificity phosphatase 1.	Protein tyrosine phosphatase receptor type R.	0.512
DUSP10	DUSP16	ENSSTOP00000010463	ENSSTOP00000022833	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity phosphatase 16.	0.851
DUSP10	DUSP8	ENSSTOP00000010463	ENSSTOP00000023813	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity phosphatase 8.	0.678
DUSP10	PTPN20	ENSSTOP00000010463	ENSSTOP00000027113	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 20.	0.427
DUSP10	PTPN5	ENSSTOP00000010463	ENSSTOP00000000860	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.554
DUSP10	PTPN7	ENSSTOP00000010463	ENSSTOP00000020011	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 7.	0.451
DUSP10	PTPRR	ENSSTOP00000010463	ENSSTOP00000011775	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase receptor type R.	0.427
DUSP11	DUSP5	ENSSTOP00000017830	ENSSTOP00000018386	Dual specificity phosphatase 11.	Dual specificity phosphatase 5; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.531
DUSP13	EPM2A	ENSSTOP00000004923	ENSSTOP00000023528	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	EPM2A glucan phosphatase, laforin.	0.408
DUSP13	PTPN20	ENSSTOP00000004923	ENSSTOP00000027113	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 20.	0.427
DUSP13	PTPN5	ENSSTOP00000004923	ENSSTOP00000000860	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein tyrosine phosphatase non-receptor type 5.	0.668