(12 nodes) Heat shock protein 70kD, C-terminal domain superfamily network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPH1	Heat shock protein family H (Hsp110) member 1. (859 aa)
	PCIF1	PDX1 C-terminal inhibiting factor 1. (706 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (840 aa)
	Hspa5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
	Hspa1a	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	HYOU1	Hypoxia up-regulated 1. (997 aa)
	HSPA4L	Heat shock protein family A (Hsp70) member 4 like. (931 aa)
	Ankrd45	ANK_REP_REGION domain-containing protein. (252 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	HSPA6	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd45	HSPA1L	ENSSTOP00000013663	ENSSTOP00000018323	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.710
Ankrd45	HSPA4	ENSSTOP00000013663	ENSSTOP00000008283	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 4.	0.794
Ankrd45	HSPA4L	ENSSTOP00000013663	ENSSTOP00000013360	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 4 like.	0.794
Ankrd45	HSPA6	ENSSTOP00000013663	ENSSTOP00000022280	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family.	0.710
Ankrd45	HSPA8	ENSSTOP00000013663	ENSSTOP00000003365	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.710
Ankrd45	HSPA9	ENSSTOP00000013663	ENSSTOP00000007876	ANK_REP_REGION domain-containing protein.	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.	0.819
Ankrd45	HSPH1	ENSSTOP00000013663	ENSSTOP00000026633	ANK_REP_REGION domain-containing protein.	Heat shock protein family H (Hsp110) member 1.	0.794
Ankrd45	HYOU1	ENSSTOP00000013663	ENSSTOP00000012867	ANK_REP_REGION domain-containing protein.	Hypoxia up-regulated 1.	0.989
Ankrd45	Hspa1a	ENSSTOP00000013663	ENSSTOP00000011787	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.710
HSPA1L	Ankrd45	ENSSTOP00000018323	ENSSTOP00000013663	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	ANK_REP_REGION domain-containing protein.	0.710
HSPA1L	HSPA4	ENSSTOP00000018323	ENSSTOP00000008283	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 4.	0.928
HSPA1L	HSPA4L	ENSSTOP00000018323	ENSSTOP00000013360	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 4 like.	0.839
HSPA1L	HSPA6	ENSSTOP00000018323	ENSSTOP00000022280	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family.	0.818
HSPA1L	HSPA8	ENSSTOP00000018323	ENSSTOP00000003365	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.859
HSPA1L	HSPA9	ENSSTOP00000018323	ENSSTOP00000007876	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.	0.760
HSPA1L	HSPH1	ENSSTOP00000018323	ENSSTOP00000026633	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Heat shock protein family H (Hsp110) member 1.	0.855
HSPA1L	Hspa5	ENSSTOP00000018323	ENSSTOP00000010092	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.883
HSPA4	Ankrd45	ENSSTOP00000008283	ENSSTOP00000013663	Heat shock protein family A (Hsp70) member 4.	ANK_REP_REGION domain-containing protein.	0.794
HSPA4	HSPA1L	ENSSTOP00000008283	ENSSTOP00000018323	Heat shock protein family A (Hsp70) member 4.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.928
HSPA4	HSPA4L	ENSSTOP00000008283	ENSSTOP00000013360	Heat shock protein family A (Hsp70) member 4.	Heat shock protein family A (Hsp70) member 4 like.	0.570