(13 nodes) Gamma-carboxyglutamic acid-rich (GLA) domain superfamily network (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRRG2	Proline rich and Gla domain 2. (202 aa)
	BGLAP	Osteocalcin; Binds strongly to apatite and calcium. (95 aa)
	PRRG1	Proline rich and Gla domain 1. (218 aa)
	GAS6	Growth arrest specific 6. (654 aa)
	F7	Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)
	F10	Coagulation factor X. (483 aa)
	PROS1	Protein S. (674 aa)
	PRRG4	Proline rich and Gla domain 4. (227 aa)
	PRRG3	Proline rich and Gla domain 3. (229 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	F9	Coagulation factor IX. (463 aa)
	MGP	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa)
	PROC	Protein C, inactivator of coagulation factors Va and VIIIa. (460 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGLAP	MGP	ENSSTOP00000017550	ENSSTOP00000010086	Osteocalcin; Binds strongly to apatite and calcium.	Matrix Gla protein; Associates with the organic matrix of bone and cartilage.	0.589
F10	F2	ENSSTOP00000020517	ENSSTOP00000004608	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.992
F10	F7	ENSSTOP00000020517	ENSSTOP00000021387	Coagulation factor X.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.952
F10	F9	ENSSTOP00000020517	ENSSTOP00000009692	Coagulation factor X.	Coagulation factor IX.	0.879
F10	PROC	ENSSTOP00000020517	ENSSTOP00000010951	Coagulation factor X.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.705
F10	PROS1	ENSSTOP00000020517	ENSSTOP00000002227	Coagulation factor X.	Protein S.	0.484
F2	F10	ENSSTOP00000004608	ENSSTOP00000020517	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.992
F2	F7	ENSSTOP00000004608	ENSSTOP00000021387	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.922
F2	F9	ENSSTOP00000004608	ENSSTOP00000009692	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.927
F2	PROC	ENSSTOP00000004608	ENSSTOP00000010951	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.994
F2	PROS1	ENSSTOP00000004608	ENSSTOP00000002227	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein S.	0.465
F7	F10	ENSSTOP00000021387	ENSSTOP00000020517	Coagulation factor VII; Belongs to the peptidase S1 family.	Coagulation factor X.	0.952
F7	F2	ENSSTOP00000021387	ENSSTOP00000004608	Coagulation factor VII; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.922
F7	F9	ENSSTOP00000021387	ENSSTOP00000009692	Coagulation factor VII; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.851
F7	PROC	ENSSTOP00000021387	ENSSTOP00000010951	Coagulation factor VII; Belongs to the peptidase S1 family.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.715
F7	PROS1	ENSSTOP00000021387	ENSSTOP00000002227	Coagulation factor VII; Belongs to the peptidase S1 family.	Protein S.	0.496
F9	F10	ENSSTOP00000009692	ENSSTOP00000020517	Coagulation factor IX.	Coagulation factor X.	0.879
F9	F2	ENSSTOP00000009692	ENSSTOP00000004608	Coagulation factor IX.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.927
F9	F7	ENSSTOP00000009692	ENSSTOP00000021387	Coagulation factor IX.	Coagulation factor VII; Belongs to the peptidase S1 family.	0.851
F9	PROC	ENSSTOP00000009692	ENSSTOP00000010951	Coagulation factor IX.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.707