24 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (467 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1103 aa)
	RFC1	Replication factor C subunit 1. (1118 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1968 aa)
	LIG3	DNA ligase. (1013 aa)
	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1185 aa)
	MCPH1	Microcephalin 1. (807 aa)
	POLM	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
	BARD1	BRCA1 associated RING domain 1. (776 aa)
	Brca1	Uncharacterized protein. (353 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1527 aa)
	LIG4	DNA ligase. (911 aa)
	MDC1	Mediator of DNA damage checkpoint 1. (1845 aa)
	Ect2	Uncharacterized protein. (188 aa)
	PAXIP1	PAX interacting protein 1. (1032 aa)
	TERF2IP	TERF2 interacting protein. (396 aa)
	XRCC1	X-ray repair cross complementing 1. (632 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1246 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (1057 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (585 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (884 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	Brca1	ENSSTOP00000002162	ENSSTOP00000000449	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.991
BARD1	LIG4	ENSSTOP00000002162	ENSSTOP00000023308	BRCA1 associated RING domain 1.	DNA ligase.	0.566
BARD1	MDC1	ENSSTOP00000002162	ENSSTOP00000016617	BRCA1 associated RING domain 1.	Mediator of DNA damage checkpoint 1.	0.807
BARD1	NBN	ENSSTOP00000002162	ENSSTOP00000013605	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.991
BARD1	PARP1	ENSSTOP00000002162	ENSSTOP00000014322	BRCA1 associated RING domain 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.504
BARD1	PAXIP1	ENSSTOP00000002162	ENSSTOP00000015892	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.807
BARD1	PES1	ENSSTOP00000002162	ENSSTOP00000012493	BRCA1 associated RING domain 1.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.499
BARD1	REV1	ENSSTOP00000002162	ENSSTOP00000012850	BRCA1 associated RING domain 1.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.515
BARD1	RFC1	ENSSTOP00000002162	ENSSTOP00000006348	BRCA1 associated RING domain 1.	Replication factor C subunit 1.	0.722
BARD1	SLF1	ENSSTOP00000002162	ENSSTOP00000012592	BRCA1 associated RING domain 1.	SMC5-SMC6 complex localization factor 1.	0.998
BARD1	TOPBP1	ENSSTOP00000002162	ENSSTOP00000027974	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.991
BARD1	TP53BP1	ENSSTOP00000002162	ENSSTOP00000006259	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein 1.	0.906
Brca1	BARD1	ENSSTOP00000000449	ENSSTOP00000002162	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.991
Brca1	LIG4	ENSSTOP00000000449	ENSSTOP00000023308	Uncharacterized protein.	DNA ligase.	0.440
Brca1	MCPH1	ENSSTOP00000000449	ENSSTOP00000002764	Uncharacterized protein.	Microcephalin 1.	0.423
Brca1	MDC1	ENSSTOP00000000449	ENSSTOP00000016617	Uncharacterized protein.	Mediator of DNA damage checkpoint 1.	0.725
Brca1	NBN	ENSSTOP00000000449	ENSSTOP00000013605	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.931
Brca1	PARP1	ENSSTOP00000000449	ENSSTOP00000014322	Uncharacterized protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.631
Brca1	PAXIP1	ENSSTOP00000000449	ENSSTOP00000015892	Uncharacterized protein.	PAX interacting protein 1.	0.725
Brca1	REV1	ENSSTOP00000000449	ENSSTOP00000012850	Uncharacterized protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.433