STRINGSTRING
ATG4A ATG4A ULK2 ULK2 PINK1 PINK1 Becn1 Becn1 DYNC1I1 DYNC1I1 ATG13 ATG13 ATG16L1 ATG16L1 ATG7 ATG7 DYNLL2 DYNLL2 LOC101964795 LOC101964795 ENSSTOP00000026846 ENSSTOP00000026846 PEX5 PEX5 PRKAG2 PRKAG2 PEX5L PEX5L CHMP4A CHMP4A TOMM22 TOMM22 CRYBB3 CRYBB3 TUBA1B TUBA1B DYNC1I2 DYNC1I2 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000028723 ENSSTOP00000028723 ENSSTOP00000028911 ENSSTOP00000028911 ENSSTOP00000029566 ENSSTOP00000029566 MLST8 MLST8 Wdr45 Wdr45 MFN2 MFN2 Ly6g5b Ly6g5b Tomm5 Tomm5 PRKAB2 PRKAB2 MTMR3 MTMR3 RPTOR RPTOR ENSSTOP00000031366 ENSSTOP00000031366 ENSSTOP00000031651 ENSSTOP00000031651 TOMM40L TOMM40L NBR1 NBR1 MTOR MTOR SQSTM1 SQSTM1 PLIN2 PLIN2 TUBA3D TUBA3D ENSSTOP00000024412 ENSSTOP00000024412 ATG4C ATG4C ENSSTOP00000024214 ENSSTOP00000024214 PRKAA1 PRKAA1 TUBA4A TUBA4A I3NG54_ICTTR I3NG54_ICTTR Chmp2a Chmp2a LOC101970177 LOC101970177 TOMM6 TOMM6 TUBB2B TUBB2B LOC101974345 LOC101974345 ATG14 ATG14 PARK7 PARK7 LOC101961494 LOC101961494 TUBA1A TUBA1A GABARAPL2 GABARAPL2 I3NBU5_ICTTR I3NBU5_ICTTR LAMTOR1 LAMTOR1 Atg9a Atg9a TUBB4A TUBB4A LOC101974619 LOC101974619 BECN2 BECN2 TUBB6 TUBB6 DYNLL1 DYNLL1 LAMTOR2 LAMTOR2 VIM VIM Chmp3 Chmp3 AMBRA1 AMBRA1 Tuba1c Tuba1c LOC101966763 LOC101966763 TUBB2A TUBB2A LOC101973486 LOC101973486 CHMP6 CHMP6 I3N4J8_ICTTR I3N4J8_ICTTR SLC38A9 SLC38A9 KIAA1671 KIAA1671 PRKN PRKN Tomm20 Tomm20 WDR45B WDR45B LOC101964833 LOC101964833 Tubb3 Tubb3 LOC101976832 LOC101976832 ATG4D ATG4D UVRAG UVRAG FUNDC1 FUNDC1 USP30 USP30 TUBB4B TUBB4B TUBB1 TUBB1 I3MU26_ICTTR I3MU26_ICTTR GABARAP GABARAP MDP1 MDP1 LAMTOR4 LAMTOR4 ILRUN ILRUN ATG5 ATG5 TXNDC11 TXNDC11 I3MQN1_ICTTR I3MQN1_ICTTR CHMP7 CHMP7 FNDC3B FNDC3B IFT88 IFT88 I3MNM5_ICTTR I3MNM5_ICTTR ATG4B ATG4B PRKAG1 PRKAG1 UBE2V1 UBE2V1 HDAC6 HDAC6 ATG3 ATG3 PIK3C3 PIK3C3 TSC2 TSC2 CSNK2B CSNK2B CHMP4C CHMP4C DYNC1LI1 DYNC1LI1 TUBA8 TUBA8 CETN3 CETN3 FNDC3A FNDC3A ATG12 ATG12 CHMP2B CHMP2B ULK1 ULK1 LOC101968254 LOC101968254 RRAGC RRAGC LAMTOR3 LAMTOR3 MAP1LC3C MAP1LC3C PRKAA2 PRKAA2 DYNC1H1 DYNC1H1 Rps27a Rps27a Tomm40 Tomm40 TOMM7 TOMM7 Csnk2a1 Csnk2a1 PRKAB1 PRKAB1 MTERF3 MTERF3 Fundc2 Fundc2 VDAC1 VDAC1 DYNC1LI2 DYNC1LI2 PCNT PCNT TUBAL3 TUBAL3 RRAGD RRAGD TOMM70 TOMM70 PRKAG3 PRKAG3 MAP1LC3A MAP1LC3A I3M6L1_ICTTR I3M6L1_ICTTR CHMP4B CHMP4B ATG10 ATG10 MFN1 MFN1 UBA52 UBA52 RRAGB RRAGB RHEB RHEB CRYGN CRYGN ATM ATM RHEBL1 RHEBL1 ATG16L2 ATG16L2 CSNK2A2 CSNK2A2 TSC1 TSC1 LAMTOR5 LAMTOR5 WIPI1 WIPI1 RB1CC1 RB1CC1 ARL13B ARL13B Tm9sf1 Tm9sf1 GABARAPL1 GABARAPL1 I3LZW4_ICTTR I3LZW4_ICTTR MTMR14 MTMR14 LOC101954381 LOC101954381 WIPI2 WIPI2 PIK3R4 PIK3R4 ATG9B ATG9B C17orf75 C17orf75 ATG101 ATG101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
PINK1PTEN induced kinase 1. (574 aa)
Becn1Beclin 1. (448 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (628 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
DYNLL2Dynein light chain. (89 aa)
LOC101964795Uncharacterized protein. (108 aa)
ENSSTOP00000026846Dynein light chain. (70 aa)
PEX5Peroxisomal biogenesis factor 5. (640 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (650 aa)
CHMP4ACharged multivesicular body protein 4A. (259 aa)
TOMM22Translocase of outer mitochondrial membrane 22. (143 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (331 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (638 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000028723Uncharacterized protein. (167 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
ENSSTOP00000029566UBIQUITIN_CONJUGAT_2 domain-containing protein. (122 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
Wdr45Uncharacterized protein. (360 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Ly6g5bUncharacterized protein. (195 aa)
Tomm5Uncharacterized protein. (51 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
MTMR3Myotubularin related protein 3. (1006 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
ENSSTOP00000031651Tubulin domain-containing protein; Belongs to the tubulin family. (219 aa)
TOMM40LTranslocase of outer mitochondrial membrane 40 like. (308 aa)
NBR1NBR1 autophagy cargo receptor. (975 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SQSTM1Sequestosome 1. (440 aa)
PLIN2Perilipin; Belongs to the perilipin family. (443 aa)
TUBA3DTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ENSSTOP00000024412Tubulin_C domain-containing protein. (122 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
ENSSTOP00000024214Uncharacterized protein. (151 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
I3NG54_ICTTRUncharacterized protein. (91 aa)
Chmp2aUncharacterized protein. (222 aa)
LOC101970177Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
TOMM6Translocase of outer mitochondrial membrane 6. (74 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC101974345Uncharacterized protein. (361 aa)
ATG14Autophagy related 14. (492 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
LOC101961494Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
GABARAPL2GABA type A receptor associated protein like 2. (123 aa)
I3NBU5_ICTTRUncharacterized protein. (209 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
Atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
LOC101974619Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
BECN2Beclin 2. (412 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (390 aa)
DYNLL1Dynein light chain. (89 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
VIMVimentin; Belongs to the intermediate filament family. (417 aa)
Chmp3Uncharacterized protein. (208 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1240 aa)
Tuba1cTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
TUBB2ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC101973486Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
I3N4J8_ICTTRUncharacterized protein. (126 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
KIAA1671KIAA1671. (1773 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (463 aa)
Tomm20Uncharacterized protein. (145 aa)
WDR45BWD repeat domain 45B. (344 aa)
LOC101964833CheR domain-containing protein. (301 aa)
Tubb3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
LOC101976832Uncharacterized protein. (1356 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (474 aa)
UVRAGUV radiation resistance associated. (698 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (489 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
I3MU26_ICTTRUncharacterized protein. (145 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
MDP1Uncharacterized protein. (164 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (99 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (291 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TXNDC11Thioredoxin domain containing 11. (882 aa)
I3MQN1_ICTTRUncharacterized protein. (140 aa)
CHMP7Charged multivesicular body protein 7. (445 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
IFT88Intraflagellar transport 88. (825 aa)
I3MNM5_ICTTRUncharacterized protein. (131 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (139 aa)
HDAC6Histone deacetylase 6. (1142 aa)
ATG3Autophagy-related protein 3. (314 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (783 aa)
TSC2TSC complex subunit 2. (1745 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (248 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (472 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
CETN3Centrin 3. (167 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
LOC101968254Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
RRAGCRas related GTP binding C. (320 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (153 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4615 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
Tomm40Uncharacterized protein. (361 aa)
TOMM7Translocase of outer mitochondrial membrane 7. (55 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MTERF3Mitochondrial transcription termination factor 3. (417 aa)
Fundc2Uncharacterized protein. (151 aa)
VDAC1Voltage dependent anion channel 1. (292 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (502 aa)
PCNTPericentrin. (3070 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
RRAGDRas related GTP binding D. (399 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
I3M6L1_ICTTRABC transmembrane type-1 domain-containing protein. (528 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
ATG10Autophagy related 10. (220 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
RRAGBRas related GTP binding B. (374 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (147 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
RHEBL1RHEB like 1. (183 aa)
ATG16L2Autophagy related 16 like 2. (620 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (343 aa)
TSC1TSC complex subunit 1. (1164 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (422 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
ARL13BADP ribosylation factor like GTPase 13B. (424 aa)
Tm9sf1Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (606 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
MTMR14Myotubularin related protein 14. (643 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (445 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1305 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
C17orf75Chromosome 17 open reading frame 75. (359 aa)
ATG101Autophagy related 101. (218 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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