STRINGSTRING
Atf7 Atf7 USP14 USP14 MAPKAPK2 MAPKAPK2 DUSP6 DUSP6 N4BP1 N4BP1 NKIRAS2 NKIRAS2 IKBKB IKBKB IRF7 IRF7 RPS6KA2 RPS6KA2 UBA52 UBA52 ECSIT ECSIT FOS FOS TAB1 TAB1 NFKB2 NFKB2 I3LZW4_ICTTR I3LZW4_ICTTR MAPK10 MAPK10 LOC101954381 LOC101954381 PIK3R4 PIK3R4 PPP2R1A PPP2R1A PPP4R4 PPP4R4 MAPK3 MAPK3 MAPK7 MAPK7 LOC106144935 LOC106144935 MAP3K7 MAP3K7 ENSSTOP00000032279 ENSSTOP00000032279 RPS6KA1 RPS6KA1 ENSSTOP00000031366 ENSSTOP00000031366 MAPK9 MAPK9 MAP2K7 MAP2K7 NLRX1 NLRX1 MAPKAPK3 MAPKAPK3 ENSSTOP00000029566 ENSSTOP00000029566 TAB3 TAB3 RPS6KA5 RPS6KA5 ENSSTOP00000028911 ENSSTOP00000028911 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000028611 ENSSTOP00000028611 LOC101954990 LOC101954990 VRK3 VRK3 ENSSTOP00000027631 ENSSTOP00000027631 PELI3 PELI3 Ppp2cb Ppp2cb ENSSTOP00000027318 ENSSTOP00000027318 Hmgb1 Hmgb1 IKBKG IKBKG CREB5 CREB5 APP APP NLRP6 NLRP6 PPP2R1B PPP2R1B ENSSTOP00000026616 ENSSTOP00000026616 AGER AGER IRAK1 IRAK1 EEA1 EEA1 LOC101961439 LOC101961439 Usp18 Usp18 LOC101970926 LOC101970926 RBSN RBSN MAPK14 MAPK14 TIFA TIFA S100A12 S100A12 KHNYN KHNYN JUN JUN CASP10 CASP10 ALPK1 ALPK1 FOSL2 FOSL2 PPP2R5D PPP2R5D CCDC71L CCDC71L LOC101966763 LOC101966763 NFKBIB NFKBIB MAP2K4 MAP2K4 MAPK15 MAPK15 LRRC74B LRRC74B RELA RELA VWC2 VWC2 NOD2 NOD2 PELI1 PELI1 PELI2 PELI2 NOD1 NOD1 PPP4R1 PPP4R1 RELCH RELCH TAB2 TAB2 CREB1 CREB1 CHUK CHUK LRRC31 LRRC31 LRRC34 LRRC34 MAPK11 MAPK11 RIPK2 RIPK2 MAPK1 MAPK1 UBE2V1 UBE2V1 FNBP4 FNBP4 ATF2 ATF2 IRAK2 IRAK2 Dusp3 Dusp3 PIK3C3 PIK3C3 NLRP12 NLRP12 MAPK8 MAPK8 TRAF2 TRAF2 NFKB1 NFKB1 CASP8 CASP8 ATF1 ATF1 LRRC71 LRRC71 PPP2CA PPP2CA NKIRAS1 NKIRAS1 RPS6KA3 RPS6KA3 Lrrc14 Lrrc14 I3MEP9_ICTTR I3MEP9_ICTTR ELK1 ELK1 NLRC5 NLRC5 DUSP4 DUSP4 MAP2K3 MAP2K3 Rps27a Rps27a Map3k20 Map3k20 LRRC74A LRRC74A NFKBIA NFKBIA LRRC45 LRRC45 TRAF6 TRAF6 MAP3K1 MAP3K1 LOC101966186 LOC101966186
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Atf7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (500 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
N4BP1NEDD4 binding protein 1. (827 aa)
NKIRAS2Uncharacterized protein. (191 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IRF7Interferon regulatory factor 7. (472 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ECSITECSIT signalling integrator. (432 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1305 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (835 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
LOC106144935Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (100 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSSTOP00000032279Uncharacterized protein. (137 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
NLRX1NLR family member X1. (975 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
ENSSTOP00000029566UBIQUITIN_CONJUGAT_2 domain-containing protein. (122 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
RPS6KA5Ribosomal protein S6 kinase. (859 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000028611Uncharacterized protein. (195 aa)
LOC101954990Tyrosine-protein phosphatase domain-containing protein. (231 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (444 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027318BZIP domain-containing protein. (133 aa)
Hmgb1Uncharacterized protein. (188 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
APPAmyloid beta precursor protein. (739 aa)
NLRP6NLR family pyrin domain containing 6. (880 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
ENSSTOP00000026616Uncharacterized protein. (174 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
EEA1Early endosome antigen 1. (1412 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
LOC101970926Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
RBSNRabenosyn, RAB effector. (766 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TIFATRAF interacting protein with forkhead associated domain. (184 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
KHNYNKH and NYN domain containing. (669 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
ALPK1Alpha kinase 1. (1226 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
CCDC71LUncharacterized protein. (176 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
MAPK15Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
LRRC74BLeucine rich repeat containing 74B. (397 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (951 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (934 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
LRRC31Leucine rich repeat containing 31. (494 aa)
LRRC34Leucine rich repeat containing 34. (459 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (139 aa)
FNBP4Formin binding protein 4. (1071 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (616 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (783 aa)
NLRP12NLR family pyrin domain containing 12. (975 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
ATF1Activating transcription factor 1. (269 aa)
LRRC71Leucine rich repeat containing 71. (507 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
Lrrc14Uncharacterized protein. (214 aa)
I3MEP9_ICTTRUncharacterized protein. (396 aa)
ELK1ETS transcription factor ELK1. (428 aa)
NLRC5NLR family CARD domain containing 5. (1847 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
Map3k20Uncharacterized protein. (800 aa)
LRRC74ALeucine rich repeat containing 74A. (463 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
LOC101966186Uncharacterized protein. (159 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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