STRINGSTRING
CBL CBL LOC101966144 LOC101966144 ENSSTOP00000031366 ENSSTOP00000031366 Csde1 Csde1 Eps15 Eps15 LOC101969002 LOC101969002 SOS1 SOS1 ENSSTOP00000028703 ENSSTOP00000028703 HRAS HRAS ARHGEF7 ARHGEF7 LOC101975023 LOC101975023 PTPRM PTPRM EPS15L1 EPS15L1 PIK3R1 PIK3R1 LOC101954671 LOC101954671 TGFA TGFA PTPN3 PTPN3 HBEGF HBEGF SH3KBP1 SH3KBP1 RNF222 RNF222 STAM STAM ERAS ERAS SPRY1 SPRY1 CSK CSK PTPN11 PTPN11 LOC101966763 LOC101966763 I3N4S4_ICTTR I3N4S4_ICTTR LRIG1 LRIG1 LOC101976832 LOC101976832 Spry2 Spry2 GAB1 GAB1 TGFB1I1 TGFB1I1 STAM2 STAM2 NRAS NRAS LPXN LPXN FNDC3B FNDC3B PAG1 PAG1 PXN PXN BTC BTC Aamp Aamp PIK3CA PIK3CA SH3GL3 SH3GL3 GRB2 GRB2 PTPRK PTPRK FNDC3A FNDC3A PLCG1 PLCG1 Rps27a Rps27a KRAS KRAS PTPRT PTPRT AREG AREG SH3GL1 SH3GL1 EGFR EGFR UBA52 UBA52 EPGN EPGN LOC101973790 LOC101973790 LRIG3 LRIG3 Cdc42 Cdc42 LRIG2 LRIG2 EREG EREG HGS HGS SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLCbl proto-oncogene. (870 aa)
LOC101966144Uncharacterized protein. (147 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
Csde1Uncharacterized protein. (555 aa)
Eps15Uncharacterized protein. (925 aa)
LOC101969002Uncharacterized protein. (639 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (713 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (935 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC101954671Uncharacterized protein. (369 aa)
TGFATransforming growth factor alpha. (159 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (882 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (690 aa)
RNF222Ring finger protein 222. (211 aa)
STAMSignal transducing adaptor molecule. (535 aa)
ERASES cell expressed Ras. (227 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
CSKTyrosine-protein kinase. (450 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1075 aa)
LOC101976832Uncharacterized protein. (1356 aa)
Spry2Uncharacterized protein. (315 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (479 aa)
STAM2Signal transducing adaptor molecule 2. (524 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (430 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
BTCBetacellulin. (143 aa)
AampWD_REPEATS_REGION domain-containing protein. (435 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1392 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1421 aa)
AREGAmphiregulin. (252 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
EPGNEpithelial mitogen. (153 aa)
LOC101973790Uncharacterized protein. (311 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1072 aa)
Cdc42Uncharacterized protein. (191 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1062 aa)
EREGEpiregulin. (163 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
SHC1SHC adaptor protein 1. (583 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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