STRINGSTRING
HBEGF HBEGF SH3KBP1 SH3KBP1 STAM STAM SPRY1 SPRY1 LOC101966763 LOC101966763 I3N4S4_ICTTR I3N4S4_ICTTR Spry2 Spry2 STAM2 STAM2 ENSSTOP00000031366 ENSSTOP00000031366 LOC101966144 LOC101966144 ENSSTOP00000028703 ENSSTOP00000028703 ARHGEF7 ARHGEF7 BTC BTC PTPRM PTPRM EPS15L1 EPS15L1 TGFA TGFA Eps15 Eps15 LOC101969002 LOC101969002 SH3GL3 SH3GL3 GRB2 GRB2 PTPRK PTPRK Rps27a Rps27a PTPRT PTPRT AREG AREG SH3GL1 SH3GL1 HGS HGS EREG EREG Cdc42 Cdc42 LOC101973790 LOC101973790 EPGN EPGN UBA52 UBA52 CBL CBL EGFR EGFR PTPN3 PTPN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFHeparin binding EGF like growth factor. (208 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (690 aa)
STAMSignal transducing adaptor molecule. (535 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
Spry2Uncharacterized protein. (315 aa)
STAM2Signal transducing adaptor molecule 2. (524 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
LOC101966144Uncharacterized protein. (147 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (713 aa)
BTCBetacellulin. (143 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (935 aa)
TGFATransforming growth factor alpha. (159 aa)
Eps15Uncharacterized protein. (925 aa)
LOC101969002Uncharacterized protein. (639 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1392 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1421 aa)
AREGAmphiregulin. (252 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
EREGEpiregulin. (163 aa)
Cdc42Uncharacterized protein. (191 aa)
LOC101973790Uncharacterized protein. (311 aa)
EPGNEpithelial mitogen. (153 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CBLCbl proto-oncogene. (870 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (882 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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