103 items (Ictidomys tridecemlineatus) - STRING interaction network

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RALA	RAS like proto-oncogene A. (206 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1261 aa)
	NAB1	NGFI-A binding protein 1. (487 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	Shc2	Uncharacterized protein. (581 aa)
	Csde1	Uncharacterized protein. (555 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (305 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (859 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	LOC101954990	Tyrosine-protein phosphatase domain-containing protein. (231 aa)
	ENSSTOP00000028027	Protein kinase domain-containing protein. (300 aa)
	VRK3	VRK serine/threonine kinase 3. (453 aa)
	LOC101975023	CSD_1 domain-containing protein. (729 aa)
	ENSSTOP00000027631	SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
	Ppp2cb	Serine/threonine-protein phosphatase. (274 aa)
	ENSSTOP00000027318	BZIP domain-containing protein. (133 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (658 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	ENSSTOP00000026011	BHLH domain-containing protein. (102 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1687 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	CRK	CRK proto-oncogene, adaptor protein. (305 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	I3LWF9_ICTTR	SH2 domain-containing protein. (118 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
	MAPK3	Mitogen-activated protein kinase. (361 aa)
	PPP4R4	Protein phosphatase 4 regulatory subunit 4. (835 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	AP2B1	AP complex subunit beta. (951 aa)
	Map2k2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (754 aa)
	Trib2	Protein kinase domain-containing protein. (343 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1667 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (275 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	EGR2	Early growth response 2. (423 aa)
	Rhoa	Ras homolog family member A. (193 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
	Chd4	Uncharacterized protein. (1909 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	NTRK1	Tyrosine-protein kinase receptor. (799 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	ELK1	ETS transcription factor ELK1. (428 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	ATF1	Activating transcription factor 1. (269 aa)
	Ralgds	Uncharacterized protein. (894 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (914 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	KIDINS220	Kinase D interacting substrate 220. (1795 aa)
	Dusp3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	FNBP4	Formin binding protein 4. (1071 aa)
	SRF	Serum response factor. (505 aa)
	MAPK1	Mitogen-activated protein kinase. (331 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	NAB2	NGFI-A binding protein 2. (525 aa)
	Sgk1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
	PPP4R1	Protein phosphatase 4 regulatory subunit 1. (934 aa)
	TRIB1	Tribbles pseudokinase 1. (372 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	LOC101975126	Uncharacterized protein. (498 aa)
	MAPK15	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	NKPD1	NTPase KAP family P-loop domain containing 1. (605 aa)
	EGR3	Early growth response 3. (387 aa)
	LYL1	LYL1 basic helix-loop-helix family member. (279 aa)
	LOC101959358	Uncharacterized protein. (193 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
	RIT1	Ras like without CAAX 1. (219 aa)
	ERAS	ES cell expressed Ras. (227 aa)
	EGR4	Early growth response 4. (484 aa)
	DNAL4	Dynein light chain. (105 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (190 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	I3NC46_ICTTR	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
	RIT2	Ras like without CAAX 2. (217 aa)
	ARC	Activity regulated cytoskeleton associated protein. (391 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2A2	ENSSTOP00000024091	ENSSTOP00000010125	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.926
AP2A1	AP2B1	ENSSTOP00000024091	ENSSTOP00000001819	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.995
AP2A1	AP2M1	ENSSTOP00000024091	ENSSTOP00000007414	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A1	CLTA	ENSSTOP00000024091	ENSSTOP00000027247	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.961
AP2A1	CLTC	ENSSTOP00000024091	ENSSTOP00000025586	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.963
AP2A1	CLTCL1	ENSSTOP00000024091	ENSSTOP00000002551	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.951
AP2A1	Csde1	ENSSTOP00000024091	ENSSTOP00000031051	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Uncharacterized protein.	0.419
AP2A1	ERAS	ENSSTOP00000024091	ENSSTOP00000020926	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	ES cell expressed Ras.	0.419
AP2A1	GRB2	ENSSTOP00000024091	ENSSTOP00000011345	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Growth factor receptor bound protein 2.	0.730
AP2A1	HRAS	ENSSTOP00000024091	ENSSTOP00000028539	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	HRas proto-oncogene, GTPase.	0.419
AP2A1	KRAS	ENSSTOP00000024091	ENSSTOP00000008545	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	KRAS proto-oncogene, GTPase.	0.419
AP2A1	LOC101959358	ENSSTOP00000024091	ENSSTOP00000018628	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Uncharacterized protein.	0.428
AP2A1	LOC101975023	ENSSTOP00000024091	ENSSTOP00000027900	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	CSD_1 domain-containing protein.	0.419
AP2A1	NGF	ENSSTOP00000024091	ENSSTOP00000030580	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Nerve growth factor; Belongs to the NGF-beta family.	0.556
AP2A1	NRAS	ENSSTOP00000024091	ENSSTOP00000015289	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	NRAS proto-oncogene, GTPase.	0.419
AP2A1	NTRK1	ENSSTOP00000024091	ENSSTOP00000007027	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Tyrosine-protein kinase receptor.	0.533
AP2A1	RALA	ENSSTOP00000024091	ENSSTOP00000022666	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	RAS like proto-oncogene A.	0.419
AP2A1	RALB	ENSSTOP00000024091	ENSSTOP00000001078	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	RAS like proto-oncogene B.	0.419
AP2A1	RAP1A	ENSSTOP00000024091	ENSSTOP00000015017	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	RAP1A, member of RAS oncogene family.	0.419
AP2A1	RIT1	ENSSTOP00000024091	ENSSTOP00000020663	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Ras like without CAAX 1.	0.419