5 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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gene neighborhood

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Your Input:
	Clps	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (111 aa)
	PNLIP	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius. (465 aa)
	PNLIPRP1	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (481 aa)
	CEL	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEL	Clps	ENSSTOP00000020482	ENSSTOP00000021080	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.897
CEL	PNLIP	ENSSTOP00000020482	ENSSTOP00000002036	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.982
CEL	PNLIPRP1	ENSSTOP00000020482	ENSSTOP00000007943	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.960
CEL	PNLIPRP2	ENSSTOP00000020482	ENSSTOP00000007959	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.922
Clps	CEL	ENSSTOP00000021080	ENSSTOP00000020482	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.897
Clps	PNLIP	ENSSTOP00000021080	ENSSTOP00000002036	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.996
Clps	PNLIPRP1	ENSSTOP00000021080	ENSSTOP00000007943	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.990
Clps	PNLIPRP2	ENSSTOP00000021080	ENSSTOP00000007959	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.975
PNLIP	CEL	ENSSTOP00000002036	ENSSTOP00000020482	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.982
PNLIP	Clps	ENSSTOP00000002036	ENSSTOP00000021080	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.996
PNLIP	PNLIPRP1	ENSSTOP00000002036	ENSSTOP00000007943	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.923
PNLIP	PNLIPRP2	ENSSTOP00000002036	ENSSTOP00000007959	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.892
PNLIPRP1	CEL	ENSSTOP00000007943	ENSSTOP00000020482	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.960
PNLIPRP1	Clps	ENSSTOP00000007943	ENSSTOP00000021080	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.990
PNLIPRP1	PNLIP	ENSSTOP00000007943	ENSSTOP00000002036	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.923
PNLIPRP1	PNLIPRP2	ENSSTOP00000007943	ENSSTOP00000007959	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.913
PNLIPRP2	CEL	ENSSTOP00000007959	ENSSTOP00000020482	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.922
PNLIPRP2	Clps	ENSSTOP00000007959	ENSSTOP00000021080	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.975
PNLIPRP2	PNLIP	ENSSTOP00000007959	ENSSTOP00000002036	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.892
PNLIPRP2	PNLIPRP1	ENSSTOP00000007959	ENSSTOP00000007943	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.913