STRINGSTRING
PHLPP2 PHLPP2 TRAT1 TRAT1 HBEGF HBEGF FLT3LG FLT3LG TGFA TGFA LOC101968118 LOC101968118 IRAK1 IRAK1 NRG4 NRG4 IL33 IL33 PIK3R1 PIK3R1 STRN3 STRN3 IL1RAP IL1RAP PPP2R1B PPP2R1B FGFR1 FGFR1 FGF8 FGF8 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 LOC101964641 LOC101964641 PPP2R5C PPP2R5C AKT1 AKT1 KITLG KITLG SPEM1 SPEM1 Pik3r3 Pik3r3 Pik3cd Pik3cd ESR2 ESR2 ICOS ICOS SPEM2 SPEM2 ENSSTOP00000030902 ENSSTOP00000030902 PIP5K1C PIP5K1C BANK1 BANK1 NRG1 NRG1 FGFR3 FGFR3 FGF6 FGF6 EREG EREG FGFR4 FGFR4 FGF20 FGF20 ERBB4 ERBB4 FNDC3A FNDC3A INSC INSC GRB2 GRB2 I3MJP5_ICTTR I3MJP5_ICTTR PIK3CA PIK3CA PPP2R5A PPP2R5A FGF17 FGF17 MYD88 MYD88 STRN STRN Irak4 Irak4 BTC BTC FRS2 FRS2 FNBP4 FNBP4 PIP4K2B PIP4K2B FGF16 FGF16 MAPK1 MAPK1 FNDC3B FNDC3B LOC101965906 LOC101965906 CD19 CD19 STRN4 STRN4 RELCH RELCH PTEN PTEN Fgf2 Fgf2 PPP4R1 PPP4R1 FGF7 FGF7 GAB1 GAB1 PPP2R5E PPP2R5E RHOG RHOG LOC101976832 LOC101976832 RAC2 RAC2 IER3 IER3 Ins Ins LOC101975126 LOC101975126 FGF22 FGF22 NRG2 NRG2 Fgf4 Fgf4 IRS1 IRS1 FGF10 FGF10 PHLPP1 PHLPP1 CD28 CD28 MET MET CD276 CD276 LOC101958853 LOC101958853 LOC101954598 LOC101954598 PDGFB PDGFB KL KL PTPN11 PTPN11 PPP2R5D PPP2R5D IL1RL1 IL1RL1 PPP2R5B PPP2R5B FGF3 FGF3 FGF19 FGF19 FGF1 FGF1 FGF18 FGF18 FGF9 FGF9 PIP5K1B PIP5K1B FAM102B FAM102B PDGFRB PDGFRB ERBB3 ERBB3 KIT KIT MAPK3 MAPK3 PPP4R4 PPP4R4 PIP4K2C PIP4K2C INSR INSR PPP2R1A PPP2R1A PIK3CB PIK3CB PIP4K2A PIP4K2A Pik3r2 Pik3r2 KLB KLB Cd86 Cd86 PIK3AP1 PIK3AP1 AKT2 AKT2 FLT3 FLT3 FAM102A FAM102A HGF HGF EPGN EPGN GAB2 GAB2 PDGFA PDGFA ERBB2 ERBB2 PIP5K1A PIP5K1A FGFR2 FGFR2 EGFR EGFR RAC1 RAC1 ESR1 ESR1 TRAF6 TRAF6 FYN FYN FGF5 FGF5 FGF23 FGF23 PIP5KL1 PIP5KL1 TRIB3 TRIB3 AREG AREG LRRC40 LRRC40 LOC101962660 LOC101962660 PPP2CA PPP2CA AKT3 AKT3 VAV1 VAV1 PDGFRA PDGFRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1322 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (299 aa)
TGFATransforming growth factor alpha. (159 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
NRG4Neuregulin 4. (123 aa)
IL33Interleukin 33. (264 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STRN3Striatin 3. (797 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
LOC101964641Uncharacterized protein. (400 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SPEM1Spermatid maturation 1. (305 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ESR2Estrogen receptor 2. (525 aa)
ICOSInducible T cell costimulator. (216 aa)
SPEM2SPEM family member 2. (500 aa)
ENSSTOP00000030902Uncharacterized protein. (380 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (726 aa)
NRG1Neuregulin 1. (700 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EREGEpiregulin. (163 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
INSCINSC spindle orientation adaptor protein. (576 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
I3MJP5_ICTTRUncharacterized protein. (324 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
STRNStriatin. (738 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
BTCBetacellulin. (143 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FNBP4Formin binding protein 4. (1071 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CD19CD19 molecule. (546 aa)
STRN4Striatin 4. (666 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (934 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
RHOGRas homolog family member G. (191 aa)
LOC101976832Uncharacterized protein. (1356 aa)
RAC2Rac family small GTPase 2. (192 aa)
IER3Immediate early response 3. (157 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC101975126Uncharacterized protein. (498 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
NRG2Neuregulin 2. (767 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1516 aa)
CD28CD28 molecule. (221 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
CD276CD276 molecule. (316 aa)
LOC101958853Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
LOC101954598Uncharacterized protein. (471 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
KLKlotho. (1008 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
IL1RL1Interleukin 1 receptor like 1. (554 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (452 aa)
FAM102BFamily with sequence similarity 102 member B. (264 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1248 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (835 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (420 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
Pik3r2Uncharacterized protein. (724 aa)
KLBKlotho beta. (1044 aa)
Cd86Ig-like domain-containing protein. (289 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (811 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
FAM102AFamily with sequence similarity 102 member A. (327 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
EPGNEpithelial mitogen. (153 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (537 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
RAC1Rac family small GTPase 1. (211 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (593 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
FYNTyrosine-protein kinase. (537 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (396 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
AREGAmphiregulin. (252 aa)
LRRC40Leucine rich repeat containing 40. (601 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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