STRINGSTRING
SNAP23 SNAP23 AP4E1 AP4E1 ACBD3 ACBD3 VAMP8 VAMP8 Vamp2 Vamp2 AP3S2 AP3S2 CPD CPD TFRC TFRC CLTCL1 CLTCL1 TPD52L1 TPD52L1 AP1G2 AP1G2 GBF1 GBF1 BLOC1S6 BLOC1S6 TBC1D9 TBC1D9 I3MV27_ICTTR I3MV27_ICTTR Sbsn Sbsn DNASE2B DNASE2B ENSSTOP00000032530 ENSSTOP00000032530 I3N0K9_ICTTR I3N0K9_ICTTR HIP1R HIP1R DNM2 DNM2 Arpin Arpin MTSS2 MTSS2 SULF1 SULF1 CLTB CLTB LOC101960968 LOC101960968 RSPH9 RSPH9 BLOC1S4 BLOC1S4 YIPF6 YIPF6 I3NBU5_ICTTR I3NBU5_ICTTR TXNDC5 TXNDC5 SORCS2 SORCS2 Vamp7 Vamp7 Tgoln2 Tgoln2 Chmp2a Chmp2a TBC1D8B TBC1D8B PICALM PICALM AP1M1 AP1M1 PUM1 PUM1 ARRB1 ARRB1 ENSSTOP00000025085 ENSSTOP00000025085 ENSSTOP00000025215 ENSSTOP00000025215 SNX2 SNX2 TPD52L2 TPD52L2 CLTC CLTC TPD52 TPD52 Zfyve19 Zfyve19 SNX6 SNX6 APP APP AP1B1 AP1B1 CLTA CLTA AP1S2 AP1S2 MTSS1 MTSS1 AP4B1 AP4B1 SNX1 SNX1 ENSSTOP00000029808 ENSSTOP00000029808 ENSSTOP00000029837 ENSSTOP00000029837 BLOC1S3 BLOC1S3 ENSSTOP00000030330 ENSSTOP00000030330 GAK GAK LOC101962636 LOC101962636 CLVS2 CLVS2 Spata17 Spata17 AP1S1 AP1S1 SNAPIN SNAPIN STX4 STX4 Spag5 Spag5 HGS HGS Ap4s1 Ap4s1 DNAJC6 DNAJC6 Ap5m1 Ap5m1 ZFYVE1 ZFYVE1 TBC1D8 TBC1D8 SORT1 SORT1 CTSZ CTSZ AP3S1 AP3S1 CLVS1 CLVS1 AP3B2 AP3B2 M6PR M6PR TBC1D9B TBC1D9B GNS GNS AP3B1 AP3B1 CLINT1 CLINT1 AP1G1 AP1G1 SNX5 SNX5 SULF2 SULF2 SORCS3 SORCS3 SORCS1 SORCS1 OCRL OCRL HCLS1 HCLS1 NECAP1 NECAP1 Bloc1s1 Bloc1s1 SNX9 SNX9 SH3D19 SH3D19 AP1S3 AP1S3 Arf1 Arf1 PIK3C2A PIK3C2A AP4M1 AP4M1 GOLGB1 GOLGB1 IGF2R IGF2R DNASE2 DNASE2 TBRG4 TBRG4 CLHC1 CLHC1 AP1M2 AP1M2 NAPA NAPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1079 aa)
ACBD3Acyl-CoA binding domain containing 3. (462 aa)
VAMP8Vesicle associated membrane protein 8. (141 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (140 aa)
AP3S2Adaptor related protein complex 3 subunit sigma 2. (193 aa)
CPDCarboxypeptidase D. (1376 aa)
TFRCTransferrin receptor. (760 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1667 aa)
TPD52L1TPD52 like 1. (204 aa)
AP1G2AP-1 complex subunit gamma. (786 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1861 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
TBC1D9TBC1 domain family member 9. (1223 aa)
I3MV27_ICTTRV-SNARE coiled-coil homology domain-containing protein. (97 aa)
SbsnUncharacterized protein. (167 aa)
DNASE2BDeoxyribonuclease 2 beta. (388 aa)
ENSSTOP00000032530MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (413 aa)
I3N0K9_ICTTRUncharacterized protein. (198 aa)
HIP1RHuntingtin interacting protein 1 related. (1037 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
ArpinUncharacterized protein. (226 aa)
MTSS2MTSS I-BAR domain containing 2. (743 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
LOC101960968Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
RSPH9Radial spoke head 9 homolog. (276 aa)
BLOC1S4Biogenesis of lysosomal organelles complex 1 subunit 4. (213 aa)
YIPF6Protein YIPF. (236 aa)
I3NBU5_ICTTRUncharacterized protein. (209 aa)
TXNDC5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (373 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1046 aa)
Vamp7Uncharacterized protein; Belongs to the synaptobrevin family. (220 aa)
Tgoln2Uncharacterized protein. (335 aa)
Chmp2aUncharacterized protein. (222 aa)
TBC1D8BTBC1 domain family member 8B. (1117 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (660 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
ARRB1Arrestin beta 1. (418 aa)
ENSSTOP00000025085Uncharacterized protein. (1609 aa)
ENSSTOP00000025215Uncharacterized protein; Belongs to the synaptobrevin family. (185 aa)
SNX2Sorting nexin 2. (523 aa)
TPD52L2TPD52 like 2. (229 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1687 aa)
TPD52Uncharacterized protein. (252 aa)
Zfyve19Uncharacterized protein. (280 aa)
SNX6Sorting nexin 6. (341 aa)
APPAmyloid beta precursor protein. (739 aa)
AP1B1AP complex subunit beta. (946 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
SNX1Sorting nexin 1. (529 aa)
ENSSTOP00000029808Uncharacterized protein. (214 aa)
ENSSTOP00000029837AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (128 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (195 aa)
ENSSTOP00000030330AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (116 aa)
GAKCyclin G associated kinase. (1322 aa)
LOC101962636Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CLVS2Clavesin 2. (327 aa)
Spata17Uncharacterized protein. (33 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (180 aa)
SNAPINSNAP associated protein. (125 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (298 aa)
Spag5Sperm associated antigen 5. (1185 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
Ap4s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (886 aa)
Ap5m1MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (490 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (777 aa)
TBC1D8TBC1 domain family member 8. (1093 aa)
SORT1Sortilin. (765 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
CLVS1Clavesin 1. (354 aa)
AP3B2AP-3 complex subunit beta. (1085 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (231 aa)
TBC1D9BTBC1 domain family member 9B. (1247 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1083 aa)
CLINT1Clathrin interactor 1. (620 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (394 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1217 aa)
SORCS1Sortilin related VPS10 domain containing receptor 1. (1019 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (901 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (478 aa)
NECAP1NECAP endocytosis associated 1. (275 aa)
Bloc1s1Uncharacterized protein. (125 aa)
SNX9Sorting nexin. (610 aa)
SH3D19SH3 domain containing 19. (938 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
Arf1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1641 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
GOLGB1Golgin B1. (3263 aa)
IGF2RInsulin like growth factor 2 receptor. (2452 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (352 aa)
TBRG4Transforming growth factor beta regulator 4. (632 aa)
CLHC1Clathrin heavy chain linker domain containing 1. (599 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
NAPANSF attachment protein alpha. (295 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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