38 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VAV3	Vav guanine nucleotide exchange factor 3. (847 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	KLRD1	Killer cell lectin like receptor D1. (178 aa)
	KLRK1	Killer cell lectin like receptor K1. (227 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	RAC1	Rac family small GTPase 1. (211 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (330 aa)
	GRAP2	GRB2 related adaptor protein 2. (324 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	LOC101974526	IG domain-containing protein. (232 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (123 aa)
	LOC101975023	CSD_1 domain-containing protein. (729 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	LAT	Linker for activation of T cells. (234 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (745 aa)
	CD300LB	CD300 molecule like family member b. (184 aa)
	ERAS	ES cell expressed Ras. (227 aa)
	LOC101972741	Uncharacterized protein. (363 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (113 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	LCP2	Lymphocyte cytosolic protein 2. (533 aa)
	CLEC5A	C-type lectin domain containing 5A. (185 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	KLRG1	Killer cell lectin like receptor G1. (188 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	I3MH84_ICTTR	Uncharacterized protein. (334 aa)
	SPNS3	Sphingolipid transporter 3 (putative). (515 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (262 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	SPNS1	Sphingolipid transporter 1 (putative). (528 aa)
	Csde1	Uncharacterized protein. (555 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	BTK	ENSSTOP00000027235	ENSSTOP00000004260	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Tyrosine-protein kinase.	0.404
B2M	GRAP2	ENSSTOP00000027235	ENSSTOP00000001984	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	GRB2 related adaptor protein 2.	0.480
B2M	GRB2	ENSSTOP00000027235	ENSSTOP00000011345	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Growth factor receptor bound protein 2.	0.494
B2M	KLRD1	ENSSTOP00000027235	ENSSTOP00000026230	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.800
B2M	KLRG1	ENSSTOP00000027235	ENSSTOP00000011187	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor G1.	0.702
B2M	KLRK1	ENSSTOP00000027235	ENSSTOP00000027181	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor K1.	0.530
B2M	LCP2	ENSSTOP00000027235	ENSSTOP00000014791	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Lymphocyte cytosolic protein 2.	0.539
B2M	PIK3CA	ENSSTOP00000027235	ENSSTOP00000011575	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.520
B2M	PIK3R1	ENSSTOP00000027235	ENSSTOP00000026032	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Phosphoinositide-3-kinase regulatory subunit 1.	0.411
B2M	Pik3r2	ENSSTOP00000027235	ENSSTOP00000001718	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.411
B2M	SOS1	ENSSTOP00000027235	ENSSTOP00000029928	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.552
B2M	SYK	ENSSTOP00000027235	ENSSTOP00000005180	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Tyrosine-protein kinase.	0.445
B2M	TYROBP	ENSSTOP00000027235	ENSSTOP00000016862	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	TYRO protein tyrosine kinase binding protein.	0.522
BTK	B2M	ENSSTOP00000004260	ENSSTOP00000027235	Tyrosine-protein kinase.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.404
BTK	FYN	ENSSTOP00000004260	ENSSTOP00000006598	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.662
BTK	GRAP2	ENSSTOP00000004260	ENSSTOP00000001984	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.831
BTK	GRB2	ENSSTOP00000004260	ENSSTOP00000011345	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.871
BTK	KLRD1	ENSSTOP00000004260	ENSSTOP00000026230	Tyrosine-protein kinase.	Killer cell lectin like receptor D1.	0.495
BTK	KLRG1	ENSSTOP00000004260	ENSSTOP00000011187	Tyrosine-protein kinase.	Killer cell lectin like receptor G1.	0.473
BTK	KLRK1	ENSSTOP00000004260	ENSSTOP00000027181	Tyrosine-protein kinase.	Killer cell lectin like receptor K1.	0.502