STRINGSTRING
GNG5 GNG5 PSME4 PSME4 AP2M1 AP2M1 NFATC1 NFATC1 FZD6 FZD6 Gnao1 Gnao1 GNGT2 GNGT2 NLK NLK PSMB5 PSMB5 RAC1 RAC1 PSMA1 PSMA1 PSMC2 PSMC2 GNB4 GNB4 UBA52 UBA52 Rhoa Rhoa GNG12 GNG12 GNG13 GNG13 WNT1 WNT1 PSMD10 PSMD10 PSMB9 PSMB9 DAAM1 DAAM1 PRKCA PRKCA CLTCL1 CLTCL1 AP2B1 AP2B1 PSMB10 PSMB10 DAAM2 DAAM2 PSMB2 PSMB2 ROR2 ROR2 GNG3 GNG3 WNT4 WNT4 PSMD4 PSMD4 PDE6G PDE6G ENSSTOP00000031366 ENSSTOP00000031366 TCF7L2 TCF7L2 PSMD12 PSMD12 Psmc1 Psmc1 ENSSTOP00000031690 ENSSTOP00000031690 MAP3K7 MAP3K7 LEF1 LEF1 PPP3CB PPP3CB FZD2 FZD2 FHDC1 FHDC1 GNG7 GNG7 FZD8 FZD8 WNT11 WNT11 WNT5A WNT5A PFN1 PFN1 PSMB8 PSMB8 WDR92 WDR92 LOC101966763 LOC101966763 AP2A2 AP2A2 FZD3 FZD3 PSMC3 PSMC3 PSMB1 PSMB1 GNB1 GNB1 GNG11 GNG11 GNGT1 GNGT1 Rps27a Rps27a PSMD1 PSMD1 PDE6H PDE6H Map3k20 Map3k20 Psmc5 Psmc5 CAMK2A CAMK2A PDE6A PDE6A GNAT2 GNAT2 DVL2 DVL2 PSMD3 PSMD3 PSMF1 PSMF1 PDE6B PDE6B AP2A1 AP2A1 ARRB2 ARRB2 PSMB3 PSMB3 ENSSTOP00000024305 ENSSTOP00000024305 PSMD13 PSMD13 LOC101972090 LOC101972090 PSMD2 PSMD2 ENSSTOP00000025153 ENSSTOP00000025153 SMURF2 SMURF2 CLTC CLTC DVL3 DVL3 PSME1 PSME1 PRKCG PRKCG PSME3 PSME3 ENSSTOP00000026289 ENSSTOP00000026289 ROR1 ROR1 PSMA5 PSMA5 PSMD11 PSMD11 PRICKLE1 PRICKLE1 Gng10 Gng10 PSME2 PSME2 CLTA CLTA ENSSTOP00000028703 ENSSTOP00000028703 PSMA4 PSMA4 Prickle4 Prickle4 FZD7 FZD7 ENSSTOP00000029537 ENSSTOP00000029537 ENSSTOP00000030001 ENSSTOP00000030001 Gng14 Gng14 CLTB CLTB I3N418_ICTTR I3N418_ICTTR TCF7L1 TCF7L1 LOC101959358 LOC101959358 PARD6A PARD6A I3N1R8_ICTTR I3N1R8_ICTTR FZD5 FZD5 GNG8 GNG8 PDE6C PDE6C RAC2 RAC2 NFAT5 NFAT5 I3MUP6_ICTTR I3MUP6_ICTTR PSMB11 PSMB11 FZD4 FZD4 TCF7 TCF7 GNG2 GNG2 GNB2 GNB2 Ppp3r1 Ppp3r1 PRICKLE2 PRICKLE2 CTNNB1 CTNNB1 Mov10 Mov10 GNG4 GNG4 PSMA8 PSMA8 GNB3 GNB3 SMURF1 SMURF1 PSMD14 PSMD14 Psmb6 Psmb6 PRICKLE3 PRICKLE3 Psmc6 Psmc6 PSMD8 PSMD8 GNB5 GNB5 RAC3 RAC3 PSMB7 PSMB7 PSMA3 PSMA3 FZD1 FZD1 PSMA2 PSMA2 PSMD7 PSMD7 PSMD5 PSMD5 DVL1 DVL1 PSMD6 PSMD6 PSMC4 PSMC4 PSMA7 PSMA7 PRKCB PRKCB WNT5B WNT5B PSMB4 PSMB4 PPP3CA PPP3CA Psma6 Psma6 Psmd9 Psmd9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PSME4Proteasome activator subunit 4. (1840 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
Gnao1G protein subunit alpha o1. (344 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PSMB5Proteasome subunit beta. (220 aa)
RAC1Rac family small GTPase 1. (211 aa)
PSMA1Proteasome subunit alpha type. (266 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
GNB4G protein subunit beta 4. (340 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
RhoaRas homolog family member A. (193 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG13G protein subunit gamma 13. (67 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
PSMB9Proteasome subunit beta. (219 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1077 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1667 aa)
AP2B1AP complex subunit beta. (951 aa)
PSMB10Proteasome subunit beta. (273 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1067 aa)
PSMB2Proteasome subunit beta. (201 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (910 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
PDE6GPhosphodiesterase 6G. (87 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
Psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
ENSSTOP00000031690ANK_REP_REGION domain-containing protein. (189 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
FHDC1FH2 domain containing 1. (1123 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (470 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PSMB8Proteasome subunit beta. (276 aa)
WDR92WD repeat domain 92. (357 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (914 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PSMB1Proteasome subunit beta. (240 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PDE6HRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones; Belongs to the rod/cone cGMP-PDE gamma subunit family. (83 aa)
Map3k20Uncharacterized protein. (800 aa)
Psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PDE6APhosphodiesterase. (860 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PDE6BPhosphodiesterase. (855 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
ARRB2Arrestin beta 2. (409 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSSTOP00000024305Uncharacterized protein. (210 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
LOC101972090AAA domain-containing protein; Belongs to the AAA ATPase family. (372 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
ENSSTOP00000025153PROTEASOME_ALPHA_1 domain-containing protein. (87 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1687 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PSME3Proteasome activator subunit 3. (254 aa)
ENSSTOP00000026289Uncharacterized protein. (885 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (956 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PRICKLE1Prickle planar cell polarity protein 1. (833 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PSME2Proteasome activator subunit 2. (239 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
Prickle4Uncharacterized protein. (362 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
ENSSTOP00000029537Proteasome subunit beta. (200 aa)
ENSSTOP00000030001AAA domain-containing protein. (334 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
LOC101959358Uncharacterized protein. (193 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
I3N1R8_ICTTRUncharacterized protein. (199 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PDE6CPhosphodiesterase. (862 aa)
RAC2Rac family small GTPase 2. (192 aa)
NFAT5Nuclear factor of activated T cells 5. (1526 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PSMB11Proteasome subunit beta. (293 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
TCF7Transcription factor 7. (302 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNB2G protein subunit beta 2. (371 aa)
Ppp3r1Uncharacterized protein. (169 aa)
PRICKLE2Prickle planar cell polarity protein 2. (767 aa)
CTNNB1Catenin beta 1. (781 aa)
Mov10AAA_12 domain-containing protein. (1054 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
PSMA8Proteasome subunit alpha type. (257 aa)
GNB3G protein subunit beta 3. (340 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
Psmb6Proteasome subunit beta. (239 aa)
PRICKLE3Prickle planar cell polarity protein 3. (613 aa)
Psmc626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (389 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
GNB5G protein subunit beta 5. (386 aa)
RAC3Rac family small GTPase 3. (185 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (643 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
Psma6Proteasome subunit alpha type. (148 aa)
Psmd9PDZ domain-containing protein. (223 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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