STRINGSTRING
ROCK1 ROCK1 ACTL9 ACTL9 ARHGEF28 ARHGEF28 SDC2 SDC2 ARPC5L ARPC5L FYN FYN EFNB2 EFNB2 Actg1 Actg1 RAC1 RAC1 TIAM1 TIAM1 KALRN KALRN I3M6C6_ICTTR I3M6C6_ICTTR Rhoa Rhoa WASL WASL ARPC1B ARPC1B Cfl2 Cfl2 Arpc1a Arpc1a GRIN2B GRIN2B Cdc42 Cdc42 RASA1 RASA1 LYN LYN ACTR3B ACTR3B ARPC4 ARPC4 ARPC3 ARPC3 EPHB4 EPHB4 EPHB2 EPHB2 GRIN1 GRIN1 EPHB6 EPHB6 ENSSTOP00000023976 ENSSTOP00000023976 I3NCC6_ICTTR I3NCC6_ICTTR LIMK2 LIMK2 ITSN1 ITSN1 FMN1 FMN1 I3N6Q6_ICTTR I3N6Q6_ICTTR I3N4S4_ICTTR I3N4S4_ICTTR ACTL7B ACTL7B ACTRT1 ACTRT1 EFNB1 EFNB1 DSTN DSTN LOC101959358 LOC101959358 ACTL8 ACTL8 LOC101971713 LOC101971713 LOC101954496 LOC101954496 FMN2 FMN2 LOC101976832 LOC101976832 ACTRT2 ACTRT2 ACTL7A ACTL7A SRC SRC FNDC3B FNDC3B ARPC2 ARPC2 EPHB1 EPHB1 Actb Actb PAK1 PAK1 FNDC3A FNDC3A ACTR3 ACTR3 Cfl1 Cfl1 ENSSTOP00000029727 ENSSTOP00000029727 ACTR2 ACTR2 EPHB3 EPHB3 ENSSTOP00000030397 ENSSTOP00000030397 EFNB3 EFNB3 PTK2 PTK2 LOC101966144 LOC101966144 ENSSTOP00000031475 ENSSTOP00000031475 ROCK2 ROCK2 ARPC5 ARPC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ACTL9Actin like 9; Belongs to the actin family. (415 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1704 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
FYNTyrosine-protein kinase. (537 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
Actg1Uncharacterized protein. (375 aa)
RAC1Rac family small GTPase 1. (211 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1567 aa)
KALRNKalirin RhoGEF kinase. (2951 aa)
I3M6C6_ICTTRADF-H domain-containing protein. (152 aa)
RhoaRas homolog family member A. (193 aa)
WASLWASP like actin nucleation promoting factor. (504 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
Cfl2ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (167 aa)
Arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
Cdc42Uncharacterized protein. (191 aa)
RASA1RAS p21 protein activator 1. (1030 aa)
LYNTyrosine-protein kinase. (512 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (417 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (176 aa)
ARPC3Actin related protein 2/3 complex subunit 3. (102 aa)
EPHB4EPH receptor B4. (987 aa)
EPHB2EPH receptor B2. (978 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
EPHB6EPH receptor B6. (1016 aa)
ENSSTOP00000023976Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
I3NCC6_ICTTRUncharacterized protein; Belongs to the actin family. (340 aa)
LIMK2LIM domain kinase 2. (638 aa)
ITSN1Intersectin 1. (1655 aa)
FMN1Formin 1. (1204 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
ACTL7BActin like 7B; Belongs to the actin family. (418 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
DSTNADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (165 aa)
LOC101959358Uncharacterized protein. (193 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LOC101971713Uncharacterized protein; Belongs to the actin family. (1238 aa)
LOC101954496Uncharacterized protein. (346 aa)
FMN2Formin 2. (1598 aa)
LOC101976832Uncharacterized protein. (1356 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (435 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
SRCTyrosine-protein kinase. (541 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
EPHB1EPH receptor B1. (984 aa)
ActbActin beta. (375 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
ENSSTOP00000029727ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (152 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
EPHB3EPH receptor B3. (996 aa)
ENSSTOP00000030397Uncharacterized protein; Belongs to the actin family. (148 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (346 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
LOC101966144Uncharacterized protein. (147 aa)
ENSSTOP00000031475Uncharacterized protein; Belongs to the actin family. (173 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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