STRINGSTRING
Pde8b Pde8b SHC1 SHC1 Pde4c Pde4c PDE1A PDE1A GRK3 GRK3 PDE10A PDE10A PDE3A PDE3A PTHLH PTHLH GRK5 GRK5 FN1 FN1 PRKAR1B PRKAR1B FAP FAP GPR20 GPR20 VIP VIP ITGA5 ITGA5 GRK6 GRK6 Arr3 Arr3 Pde11a Pde11a PRKAR1A PRKAR1A ITGB1 ITGB1 I3MMQ2_ICTTR I3MMQ2_ICTTR PDE8A PDE8A CNBD2 CNBD2 GPR176 GPR176 GRK2 GRK2 PDE3B PDE3B LOC101977951 LOC101977951 GNG2 GNG2 GPR173 GPR173 DRD1 DRD1 ADRB2 ADRB2 GPR15 GPR15 GPR85 GPR85 GPR63 GPR63 PDE4D PDE4D GPR45 GPR45 Gpr150 Gpr150 LOC101971842 LOC101971842 GPR25 GPR25 I3NH06_ICTTR I3NH06_ICTTR ARRB2 ARRB2 ARRB1 ARRB1 PRKAR2A PRKAR2A GPR21 GPR21 PDE2A PDE2A PDE1B PDE1B GPR83 GPR83 PRKACB PRKACB THAP6 THAP6 PRKACA PRKACA LOC101962180 LOC101962180 Gng14 Gng14 PDE7B PDE7B LOC101970632 LOC101970632 PDE7A PDE7A PRKAR2B PRKAR2B PDE4A PDE4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pde8bPhosphodiesterase. (865 aa)
SHC1SHC adaptor protein 1. (583 aa)
Pde4cPhosphodiesterase. (563 aa)
PDE1APhosphodiesterase. (544 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (619 aa)
PDE10APhosphodiesterase. (794 aa)
PDE3APhosphodiesterase. (1145 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (572 aa)
FN1Fibronectin 1. (2474 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
GPR20G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (356 aa)
VIPVasoactive intestinal peptide. (170 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (569 aa)
Arr3Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (393 aa)
Pde11aPhosphodiesterase. (933 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
I3MMQ2_ICTTRUncharacterized protein. (384 aa)
PDE8APhosphodiesterase. (766 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (560 aa)
GPR176G protein-coupled receptor 176. (513 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (690 aa)
PDE3BPhosphodiesterase. (1046 aa)
LOC101977951G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (459 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GPR173G protein-coupled receptor 173. (373 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
ADRB2Adrenoceptor beta 2. (416 aa)
GPR15G protein-coupled receptor 15; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GPR85G protein-coupled receptor 85. (370 aa)
GPR63G protein-coupled receptor 63. (419 aa)
PDE4DPhosphodiesterase 4D; Belongs to the cyclic nucleotide phosphodiesterase family. (808 aa)
GPR45G protein-coupled receptor 45. (372 aa)
Gpr150G_PROTEIN_RECEP_F1_2 domain-containing protein. (409 aa)
LOC101971842G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (449 aa)
GPR25G protein-coupled receptor 25; Belongs to the G-protein coupled receptor 1 family. (361 aa)
I3NH06_ICTTRMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (314 aa)
ARRB2Arrestin beta 2. (409 aa)
ARRB1Arrestin beta 1. (418 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (399 aa)
GPR21G protein-coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (348 aa)
PDE2APhosphodiesterase. (941 aa)
PDE1BPhosphodiesterase. (535 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (424 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
THAP6THAP domain containing 6. (217 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
LOC101962180Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (314 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PDE7BPhosphodiesterase. (499 aa)
LOC101970632Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (209 aa)
PDE7APhosphodiesterase. (482 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (417 aa)
PDE4APhosphodiesterase. (776 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.