51 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	AP1G1	AP-1 complex subunit gamma. (825 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (180 aa)
	CLVS2	Clavesin 2. (327 aa)
	AP1G2	AP-1 complex subunit gamma. (786 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1667 aa)
	Vamp2	V-SNARE coiled-coil homology domain-containing protein. (140 aa)
	VAMP8	Vesicle associated membrane protein 8. (141 aa)
	AP4E1	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1079 aa)
	AP1M2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
	CLHC1	Clathrin heavy chain linker domain containing 1. (599 aa)
	TBRG4	Transforming growth factor beta regulator 4. (632 aa)
	DNASE2	Deoxyribonuclease 2, lysosomal. (352 aa)
	AP4M1	AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
	Arf1	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	Bloc1s1	Uncharacterized protein. (125 aa)
	Ap4s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
	DNAJC6	DnaJ heat shock protein family (Hsp40) member C6. (886 aa)
	Ap5m1	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (490 aa)
	ZFYVE1	Zinc finger FYVE-type containing 1. (777 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	CLVS1	Clavesin 1. (354 aa)
	M6PR	Mannose-6-phosphate receptor, cation dependent. (231 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
	SULF2	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
	I3MV27_ICTTR	V-SNARE coiled-coil homology domain-containing protein. (97 aa)
	DNASE2B	Deoxyribonuclease 2 beta. (388 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
	LOC101960968	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	RSPH9	Radial spoke head 9 homolog. (276 aa)
	I3NBU5_ICTTR	Uncharacterized protein. (209 aa)
	TXNDC5	Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (373 aa)
	Vamp7	Uncharacterized protein; Belongs to the synaptobrevin family. (220 aa)
	Chmp2a	Uncharacterized protein. (222 aa)
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	ENSSTOP00000025215	Uncharacterized protein; Belongs to the synaptobrevin family. (185 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1687 aa)
	Zfyve19	Uncharacterized protein. (280 aa)
	APP	Amyloid beta precursor protein. (739 aa)
	AP1B1	AP complex subunit beta. (946 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	AP4B1	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
	ENSSTOP00000029837	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (128 aa)
	ENSSTOP00000030330	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (116 aa)
	LOC101962636	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	ENSSTOP00000032530	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (413 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1B1	AP1G1	ENSSTOP00000026949	ENSSTOP00000013710	AP complex subunit beta.	AP-1 complex subunit gamma.	0.995
AP1B1	AP1G2	ENSSTOP00000026949	ENSSTOP00000002405	AP complex subunit beta.	AP-1 complex subunit gamma.	0.994
AP1B1	AP1M1	ENSSTOP00000026949	ENSSTOP00000024089	AP complex subunit beta.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.989
AP1B1	AP1M2	ENSSTOP00000026949	ENSSTOP00000006907	AP complex subunit beta.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.989
AP1B1	AP1S1	ENSSTOP00000026949	ENSSTOP00000000664	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.995
AP1B1	AP1S2	ENSSTOP00000026949	ENSSTOP00000027602	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.991
AP1B1	AP1S3	ENSSTOP00000026949	ENSSTOP00000008615	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP1B1	AP4B1	ENSSTOP00000026949	ENSSTOP00000028269	AP complex subunit beta.	AP complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.700
AP1B1	AP4E1	ENSSTOP00000026949	ENSSTOP00000005348	AP complex subunit beta.	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.	0.973
AP1B1	AP4M1	ENSSTOP00000026949	ENSSTOP00000008107	AP complex subunit beta.	AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...]	0.954
AP1B1	ARRB1	ENSSTOP00000026949	ENSSTOP00000024223	AP complex subunit beta.	Arrestin beta 1.	0.732
AP1B1	Ap4s1	ENSSTOP00000026949	ENSSTOP00000009653	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.833
AP1B1	Ap5m1	ENSSTOP00000026949	ENSSTOP00000009934	AP complex subunit beta.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.828
AP1B1	Arf1	ENSSTOP00000026949	ENSSTOP00000008326	AP complex subunit beta.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.885
AP1B1	CLHC1	ENSSTOP00000026949	ENSSTOP00000007297	AP complex subunit beta.	Clathrin heavy chain linker domain containing 1.	0.905
AP1B1	CLTA	ENSSTOP00000026949	ENSSTOP00000027247	AP complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.923
AP1B1	CLTB	ENSSTOP00000026949	ENSSTOP00000019393	AP complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.920
AP1B1	CLTC	ENSSTOP00000026949	ENSSTOP00000025586	AP complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.967
AP1B1	CLTCL1	ENSSTOP00000026949	ENSSTOP00000002551	AP complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.967
AP1B1	CTSZ	ENSSTOP00000026949	ENSSTOP00000010502	AP complex subunit beta.	Cathepsin Z; Belongs to the peptidase C1 family.	0.653