STRINGSTRING
LOC106144935 LOC106144935 PTPN5 PTPN5 LOC101954381 LOC101954381 IL36G IL36G IL36A IL36A I3LZW4_ICTTR I3LZW4_ICTTR NFKB2 NFKB2 IL1A IL1A IL1B IL1B TAB1 TAB1 IL1RL2 IL1RL2 IL18R1 IL18R1 UBA52 UBA52 IKBKB IKBKB PTPN9 PTPN9 CUL1 CUL1 NKIRAS2 NKIRAS2 N4BP1 N4BP1 USP14 USP14 STAT3 STAT3 LOC101966186 LOC101966186 IRAK3 IRAK3 TRAF6 TRAF6 LRRC45 LRRC45 NFKBIA NFKBIA LRRC74A LRRC74A IL13 IL13 LOC101954543 LOC101954543 CTSG CTSG TBK1 TBK1 IL1R2 IL1R2 IL37 IL37 MAP3K3 MAP3K3 Map3k20 Map3k20 Rps27a Rps27a NLRC5 NLRC5 I3MEP9_ICTTR I3MEP9_ICTTR MFSD1 MFSD1 Lrrc14 Lrrc14 NKIRAS1 NKIRAS1 LRRC71 LRRC71 CASP8 CASP8 NFKB1 NFKB1 TRAF2 TRAF2 MAPK8 MAPK8 NLRP12 NLRP12 PTPN21 PTPN21 MYD88 MYD88 Irak4 Irak4 IRAK2 IRAK2 UBE2V1 UBE2V1 IL36RN IL36RN IL1F10 IL1F10 IL1RN IL1RN I3MN57_ICTTR I3MN57_ICTTR Rbx1 Rbx1 LRRC34 LRRC34 LRRC31 LRRC31 PTPN23 PTPN23 IL1RAPL1 IL1RAPL1 CHUK CHUK IL18 IL18 TAB2 TAB2 IL1R1 IL1R1 PELI2 PELI2 I3MVA2_ICTTR I3MVA2_ICTTR PELI1 PELI1 VWC2 VWC2 RELA RELA LRRC74B LRRC74B I3N110_ICTTR I3N110_ICTTR SIGIRR SIGIRR NFKBIB NFKBIB LOC101966763 LOC101966763 CCDC71L CCDC71L IL1RL1 IL1RL1 BTRC BTRC ALPK1 ALPK1 GSDMD GSDMD CASP10 CASP10 KHNYN KHNYN LOC101967492 LOC101967492 S100A12 S100A12 TIFA TIFA LOC101970926 LOC101970926 Usp18 Usp18 TOLLIP TOLLIP IL18BP IL18BP IRAK1 IRAK1 AGER AGER IL33 IL33 MAP3K2 MAP3K2 IL1RAP IL1RAP ENSSTOP00000026616 ENSSTOP00000026616 NLRP6 NLRP6 APP APP IKBKG IKBKG PTPN20 PTPN20 Hmgb1 Hmgb1 PTPN14 PTPN14 PELI3 PELI3 ENSSTOP00000028611 ENSSTOP00000028611 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000028717 ENSSTOP00000028717 ENSSTOP00000028911 ENSSTOP00000028911 TAB3 TAB3 ENSSTOP00000029566 ENSSTOP00000029566 NLRX1 NLRX1 SKP1 SKP1 ENSSTOP00000031366 ENSSTOP00000031366 ENSSTOP00000032279 ENSSTOP00000032279 MAP3K7 MAP3K7 SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106144935Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (100 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (538 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
IL36GInterleukin-1. (161 aa)
IL36AInterleukin-1. (160 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
IL1RL2Interleukin 1 receptor like 2. (567 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PTPN9Protein tyrosine phosphatase non-receptor type 9. (593 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
NKIRAS2Uncharacterized protein. (191 aa)
N4BP1NEDD4 binding protein 1. (827 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (500 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
LOC101966186Uncharacterized protein. (159 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (607 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LRRC74ALeucine rich repeat containing 74A. (463 aa)
IL13Interleukin 13. (130 aa)
LOC101954543Uncharacterized protein; Belongs to the peptidase C14A family. (365 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (262 aa)
TBK1TANK binding kinase 1. (729 aa)
IL1R2Interleukin 1 receptor type 2. (396 aa)
IL37Interleukin-1. (213 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
Map3k20Uncharacterized protein. (800 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
NLRC5NLR family CARD domain containing 5. (1847 aa)
I3MEP9_ICTTRUncharacterized protein. (396 aa)
MFSD1Major facilitator superfamily domain containing 1. (465 aa)
Lrrc14Uncharacterized protein. (214 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
LRRC71Leucine rich repeat containing 71. (507 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NLRP12NLR family pyrin domain containing 12. (975 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1108 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (616 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (139 aa)
IL36RNInterleukin-1. (130 aa)
IL1F10Interleukin-1. (152 aa)
IL1RNInterleukin-1. (177 aa)
I3MN57_ICTTRInterleukin-1. (167 aa)
Rbx1RING-type domain-containing protein. (108 aa)
LRRC34Leucine rich repeat containing 34. (459 aa)
LRRC31Leucine rich repeat containing 31. (494 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1639 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (437 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
IL1R1Interleukin 1 receptor type 1. (506 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (394 aa)
I3MVA2_ICTTRUncharacterized protein. (170 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LRRC74BLeucine rich repeat containing 74B. (397 aa)
I3N110_ICTTRRING-type domain-containing protein. (147 aa)
SIGIRRSingle Ig and TIR domain containing. (409 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
CCDC71LUncharacterized protein. (176 aa)
IL1RL1Interleukin 1 receptor like 1. (554 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ALPK1Alpha kinase 1. (1226 aa)
GSDMDGasdermin D. (489 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
KHNYNKH and NYN domain containing. (669 aa)
LOC101967492Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
TIFATRAF interacting protein with forkhead associated domain. (184 aa)
LOC101970926Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
TOLLIPToll interacting protein. (274 aa)
IL18BPInterleukin 18 binding protein. (213 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
IL33Interleukin 33. (264 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (619 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
ENSSTOP00000026616Uncharacterized protein. (174 aa)
NLRP6NLR family pyrin domain containing 6. (880 aa)
APPAmyloid beta precursor protein. (739 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
PTPN20Protein tyrosine phosphatase non-receptor type 20. (357 aa)
Hmgb1Uncharacterized protein. (188 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1186 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (444 aa)
ENSSTOP00000028611Uncharacterized protein. (195 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000028717RING-type domain-containing protein. (95 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
ENSSTOP00000029566UBIQUITIN_CONJUGAT_2 domain-containing protein. (122 aa)
NLRX1NLR family member X1. (975 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
ENSSTOP00000032279Uncharacterized protein. (137 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SQSTM1Sequestosome 1. (440 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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