STRINGSTRING
MAPK7 MAPK7 MAPK3 MAPK3 PPP4R4 PPP4R4 PPP2R1A PPP2R1A MAPK10 MAPK10 FOS FOS RPS6KA2 RPS6KA2 DUSP6 DUSP6 MAPKAPK2 MAPKAPK2 Atf7 Atf7 DUSP4 DUSP4 ELK1 ELK1 RPS6KA3 RPS6KA3 PPP2CA PPP2CA ATF1 ATF1 MAPK8 MAPK8 Dusp3 Dusp3 ATF2 ATF2 FNBP4 FNBP4 MAPK1 MAPK1 MAPK11 MAPK11 CREB1 CREB1 RELCH RELCH PPP4R1 PPP4R1 MAPK15 MAPK15 PPP2R5D PPP2R5D FOSL2 FOSL2 JUN JUN MAPK14 MAPK14 PPP2R1B PPP2R1B CREB5 CREB5 ENSSTOP00000027318 ENSSTOP00000027318 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 VRK3 VRK3 LOC101954990 LOC101954990 RPS6KA5 RPS6KA5 MAPK9 MAPK9 RPS6KA1 RPS6KA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (835 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ELK1ETS transcription factor ELK1. (428 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATF1Activating transcription factor 1. (269 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
FNBP4Formin binding protein 4. (1071 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (934 aa)
MAPK15Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
ENSSTOP00000027318BZIP domain-containing protein. (133 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
LOC101954990Tyrosine-protein phosphatase domain-containing protein. (231 aa)
RPS6KA5Ribosomal protein S6 kinase. (859 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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