STRINGSTRING
Psmc5 Psmc5 RBL2 RBL2 ENSSTOP00000031840 ENSSTOP00000031840 ENSSTOP00000031690 ENSSTOP00000031690 Psmc1 Psmc1 PSMD12 PSMD12 ENSSTOP00000031366 ENSSTOP00000031366 LIN52 LIN52 SKP1 SKP1 PPP2R2B PPP2R2B ENSSTOP00000030245 ENSSTOP00000030245 ENSSTOP00000030001 ENSSTOP00000030001 ENSSTOP00000029537 ENSSTOP00000029537 LYN LYN Mcm8 Mcm8 CDK2 CDK2 PSMA4 PSMA4 DYRK1B DYRK1B ENSSTOP00000028703 ENSSTOP00000028703 AKT1 AKT1 LIN54 LIN54 ENSSTOP00000028075 ENSSTOP00000028075 CDC7 CDC7 TFDP2 TFDP2 ENSSTOP00000027631 ENSSTOP00000027631 Ppp2cb Ppp2cb PSME2 PSME2 PSMD11 PSMD11 PSMA5 PSMA5 RPA3 RPA3 ENSSTOP00000026639 ENSSTOP00000026639 PPP2R1B PPP2R1B ENSSTOP00000026561 ENSSTOP00000026561 ENSSTOP00000026404 ENSSTOP00000026404 POLE4 POLE4 PSME3 PSME3 PSME1 PSME1 ENSSTOP00000025372 ENSSTOP00000025372 ENSSTOP00000025213 ENSSTOP00000025213 ENSSTOP00000025153 ENSSTOP00000025153 PSMD2 PSMD2 LOC101972090 LOC101972090 CKS1B CKS1B PSMD13 PSMD13 Pola1 Pola1 ENSSTOP00000024401 ENSSTOP00000024401 ENSSTOP00000024305 ENSSTOP00000024305 PSMB3 PSMB3 ENSSTOP00000024190 ENSSTOP00000024190 CCND3 CCND3 DBF4 DBF4 PSMF1 PSMF1 PSMD3 PSMD3 I3NE23_ICTTR I3NE23_ICTTR MEIOB MEIOB LOC101967492 LOC101967492 MNAT1 MNAT1 RBL1 RBL1 Tm4sf19 Tm4sf19 CDKN2B CDKN2B Pole3 Pole3 LOC101961074 LOC101961074 PRIM2 PRIM2 PSMB8 PSMB8 LOC101966763 LOC101966763 E2F3 E2F3 CDKN1A CDKN1A ORC4 ORC4 I3N1R8_ICTTR I3N1R8_ICTTR Cdkn2d Cdkn2d PPP2R2A PPP2R2A CDK7 CDK7 RPA1 RPA1 LOC101976832 LOC101976832 Ccnd2 Ccnd2 ORC2 ORC2 POLE POLE MCM2 MCM2 PPP4R1 PPP4R1 RELCH RELCH CDKN1B CDKN1B LIN37 LIN37 CDT1 CDT1 E2F4 E2F4 DYRK1A DYRK1A LIN9 LIN9 ORC1 ORC1 FNDC3B FNDC3B PSMD14 PSMD14 Psmb6 Psmb6 PPP2R3A PPP2R3A Psmc6 Psmc6 PSMD8 PSMD8 FNBP4 FNBP4 CDK6 CDK6 PSMB7 PSMB7 CDKN2C CDKN2C MCM6 MCM6 MCM5 MCM5 PSMA3 PSMA3 E2F5 E2F5 PSMA2 PSMA2 PSMD7 PSMD7 PSMD5 PSMD5 Tesmin Tesmin PSMD6 PSMD6 PSMC4 PSMC4 PSMA7 PSMA7 Hdac1 Hdac1 PSMB4 PSMB4 RBBP4 RBBP4 FNDC3A FNDC3A Psma6 Psma6 Psmd9 Psmd9 LOC101956153 LOC101956153 PSMC3 PSMC3 AKT3 AKT3 PSMB1 PSMB1 PPP2CA PPP2CA CABLES1 CABLES1 MYBL2 MYBL2 MCM4 MCM4 WEE1 WEE1 CCNE1 CCNE1 E2F2 E2F2 Rps27a Rps27a PSMD1 PSMD1 PPP2R3C PPP2R3C Prim1 Prim1 MCM7 MCM7 CCNA2 CCNA2 PTK6 PTK6 CDK3 CDK3 PSMB5 PSMB5 POLE2 POLE2 JAK2 JAK2 PSMA1 PSMA1 CUL1 CUL1 GMNN GMNN PSMC2 PSMC2 CDC6 CDC6 UBA52 UBA52 ORC3 ORC3 RPA2 RPA2 CCNE2 CCNE2 ORC5 ORC5 ORC6 ORC6 PSMD10 PSMD10 Pola2 Pola2 CCNA1 CCNA1 PSMB9 PSMB9 AKT2 AKT2 CDC45 CDC45 SKP2 SKP2 E2F1 E2F1 TFDP1 TFDP1 PSMB10 PSMB10 PSMB2 PSMB2 MCM3 MCM3 Cdk4 Cdk4 PPP2R1A PPP2R1A RB1 RB1 PPP4R4 PPP4R4 CCNH CCNH PSMD4 PSMD4 CCND1 CCND1 Cks2 Cks2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
RBL2RB transcriptional corepressor like 2. (1161 aa)
ENSSTOP00000031840Zf-primase domain-containing protein. (205 aa)
ENSSTOP00000031690ANK_REP_REGION domain-containing protein. (189 aa)
Psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ENSSTOP00000030245Uncharacterized protein. (174 aa)
ENSSTOP00000030001AAA domain-containing protein. (334 aa)
ENSSTOP00000029537Proteasome subunit beta. (200 aa)
LYNTyrosine-protein kinase. (512 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (673 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LIN54Lin-54 DREAM MuvB core complex component. (747 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
CDC7Cell division cycle 7; Belongs to the protein kinase superfamily. (498 aa)
TFDP2Transcription factor. (446 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
RPA3Replication protein A3. (121 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
ENSSTOP00000026561Uncharacterized protein. (89 aa)
ENSSTOP00000026404Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
PSME3Proteasome activator subunit 3. (254 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSSTOP00000025372CBFD_NFYB_HMF domain-containing protein. (134 aa)
ENSSTOP00000025213Uncharacterized protein. (116 aa)
ENSSTOP00000025153PROTEASOME_ALPHA_1 domain-containing protein. (87 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
LOC101972090AAA domain-containing protein; Belongs to the AAA ATPase family. (372 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
Pola1DNA polymerase. (767 aa)
ENSSTOP00000024401Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (68 aa)
ENSSTOP00000024305Uncharacterized protein. (210 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSSTOP00000024190Protein kinase domain-containing protein. (266 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
DBF4DBF4 zinc finger. (570 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
I3NE23_ICTTRANK_REP_REGION domain-containing protein. (150 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
LOC101967492Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RBL1RB transcriptional corepressor like 1. (1038 aa)
Tm4sf19Uncharacterized protein. (210 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
Pole3CBFD_NFYB_HMF domain-containing protein. (147 aa)
LOC101961074Uncharacterized protein. (295 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (503 aa)
PSMB8Proteasome subunit beta. (276 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
E2F3E2F transcription factor 3. (460 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
I3N1R8_ICTTRUncharacterized protein. (199 aa)
Cdkn2dANK_REP_REGION domain-containing protein. (166 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
LOC101976832Uncharacterized protein. (1356 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
MCM2DNA helicase; Belongs to the MCM family. (724 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (934 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
CDT1Chromatin licensing and DNA replication factor 1. (473 aa)
E2F4E2F transcription factor 4. (406 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
LIN9Lin-9 DREAM MuvB core complex component. (558 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
Psmb6Proteasome subunit beta. (239 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1149 aa)
Psmc626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (389 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
FNBP4Formin binding protein 4. (1071 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PSMB7Proteasome subunit beta. (277 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (170 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
E2F5E2F transcription factor 5. (315 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
TesminCRC domain-containing protein. (304 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
Psma6Proteasome subunit alpha type. (148 aa)
Psmd9PDZ domain-containing protein. (223 aa)
LOC101956153Mcm10 domain-containing protein. (737 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMB1Proteasome subunit beta. (240 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (506 aa)
MYBL2MYB proto-oncogene like 2. (701 aa)
MCM4DNA helicase; Belongs to the MCM family. (862 aa)
WEE1Wee1-like protein kinase. (645 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
E2F2E2F transcription factor 2. (432 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (407 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
PTK6Tyrosine-protein kinase. (450 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
PSMB5Proteasome subunit beta. (220 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PSMA1Proteasome subunit alpha type. (266 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ORC3Origin recognition complex subunit 3. (715 aa)
RPA2Replication protein A2. (271 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
ORC6Origin recognition complex subunit 6. (253 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PSMB9Proteasome subunit beta. (219 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
CDC45Cell division cycle 45. (567 aa)
SKP2S-phase kinase associated protein 2. (401 aa)
E2F1E2F transcription factor 1. (392 aa)
TFDP1Transcription factor. (410 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB2Proteasome subunit beta. (201 aa)
MCM3DNA helicase; Belongs to the MCM family. (807 aa)
Cdk4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
RB1RB transcriptional corepressor 1. (957 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (835 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
CCND1Cyclin D1. (250 aa)
Cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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