STRINGSTRING
SPRED2 SPRED2 GAB1 GAB1 Fgf2 Fgf2 NRAS NRAS Flrt1 Flrt1 FNDC3B FNDC3B MAPK1 MAPK1 FRS2 FRS2 FGF17 FGF17 PIK3CA PIK3CA GRB2 GRB2 MKNK2 MKNK2 FNDC3A FNDC3A PLCG1 PLCG1 PPP2CA PPP2CA Rps27a Rps27a KRAS KRAS FLRT3 FLRT3 FGF23 FGF23 FGF5 FGF5 FRS3 FRS3 SPRED1 SPRED1 CBL CBL FLRT2 FLRT2 UBA52 UBA52 BRAF BRAF LOC101973790 LOC101973790 PPP2R1A PPP2R1A FGF6 FGF6 MAPK3 MAPK3 LOC101976832 LOC101976832 FGF22 FGF22 Fgf4 Fgf4 FGF10 FGF10 LOC101958853 LOC101958853 SHC1 SHC1 FGF20 FGF20 ANOS1 ANOS1 LOC101966763 LOC101966763 KL KL PTPN11 PTPN11 ERAS ERAS FGF3 FGF3 FGF1 FGF1 FGF18 FGF18 FGFRL1 FGFRL1 ENSSTOP00000024013 ENSSTOP00000024013 PIK3R1 PIK3R1 FGFR1 FGFR1 Spry2 Spry2 FGF8 FGF8 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 LOC101975023 LOC101975023 HRAS HRAS ENSSTOP00000028703 ENSSTOP00000028703 SOS1 SOS1 Csde1 Csde1 ENSSTOP00000031366 ENSSTOP00000031366
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRED2Sprouty related EVH1 domain containing 2. (430 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
Flrt1Fibronectin leucine rich transmembrane protein 1. (674 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (461 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
FRS3Fibroblast growth factor receptor substrate 3. (491 aa)
SPRED1Sprouty related EVH1 domain containing 1. (445 aa)
CBLCbl proto-oncogene. (870 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
LOC101973790Uncharacterized protein. (311 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
LOC101976832Uncharacterized protein. (1356 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC101958853Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
SHC1SHC adaptor protein 1. (583 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ANOS1Anosmin 1. (637 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
KLKlotho. (1008 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ERASES cell expressed Ras. (227 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFRL1Fibroblast growth factor receptor like 1. (478 aa)
ENSSTOP00000024013Uncharacterized protein. (102 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
Spry2Uncharacterized protein. (315 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
Csde1Uncharacterized protein. (555 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.