STRINGSTRING
PIK3R1 PIK3R1 GRB2 GRB2 PIK3CA PIK3CA FGF17 FGF17 FRS2 FRS2 FGF16 FGF16 MAPK1 MAPK1 FNDC3B FNDC3B NRAS NRAS Fgf2 Fgf2 GAB1 GAB1 Spry2 Spry2 LOC101976832 LOC101976832 Fgf4 Fgf4 LOC101958853 LOC101958853 LOC101966763 LOC101966763 PTPN11 PTPN11 ERAS ERAS FGF1 FGF1 FGF18 FGF18 FGF9 FGF9 ENSSTOP00000024013 ENSSTOP00000024013 MKNK2 MKNK2 FGF8 FGF8 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 LOC101975023 LOC101975023 HRAS HRAS ENSSTOP00000028703 ENSSTOP00000028703 SOS1 SOS1 Csde1 Csde1 ENSSTOP00000031366 ENSSTOP00000031366 FGFR3 FGFR3 FNDC3A FNDC3A PLCG1 PLCG1 PPP2CA PPP2CA Rps27a Rps27a KRAS KRAS FGF23 FGF23 FGF5 FGF5 FRS3 FRS3 CBL CBL UBA52 UBA52 BRAF BRAF LOC101973790 LOC101973790 PPP2R1A PPP2R1A MAPK3 MAPK3 GALNT3 GALNT3 FGF20 FGF20 SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
FNDC3BFibronectin type III domain containing 3B. (1208 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
Spry2Uncharacterized protein. (315 aa)
LOC101976832Uncharacterized protein. (1356 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LOC101958853Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ERASES cell expressed Ras. (227 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSSTOP00000024013Uncharacterized protein. (102 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (461 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
Csde1Uncharacterized protein. (555 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
FRS3Fibroblast growth factor receptor substrate 3. (491 aa)
CBLCbl proto-oncogene. (870 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
LOC101973790Uncharacterized protein. (311 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SHC1SHC adaptor protein 1. (583 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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