STRINGSTRING
ENSSTOP00000031366 ENSSTOP00000031366 EXD2 EXD2 I3LWG0_ICTTR I3LWG0_ICTTR RFC3 RFC3 Pold3 Pold3 Brca1 Brca1 I3LWU8_ICTTR I3LWU8_ICTTR EME2 EME2 BARD1 BARD1 XRCC2 XRCC2 CHEK1 CHEK1 POLD2 POLD2 RAD51C RAD51C MUS81 MUS81 RPA2 RPA2 ATM ATM UBA52 UBA52 BLM BLM I3M6A8_ICTTR I3M6A8_ICTTR POLE2 POLE2 RFC1 RFC1 EME1 EME1 Rps27a Rps27a Rad50 Rad50 POLH POLH SPIDR SPIDR BRIP1 BRIP1 POLD1 POLD1 DNA2 DNA2 Rbbp8 Rbbp8 Rfc4 Rfc4 WRN WRN GEN1 GEN1 RCBTB2 RCBTB2 TOP3A TOP3A NBN NBN Pold4 Pold4 RAD51B RAD51B XRCC3 XRCC3 Palb2 Palb2 I3MU87_ICTTR I3MU87_ICTTR I3MUA8_ICTTR I3MUA8_ICTTR POLE POLE RPA1 RPA1 RMI1 RMI1 SLX4 SLX4 Slx1a Slx1a RFC2 RFC2 LOC101966763 LOC101966763 LOC101971599 LOC101971599 Pole3 Pole3 MEIOB MEIOB Pcna Pcna Rfc5 Rfc5 MRE11 MRE11 ENSSTOP00000025372 ENSSTOP00000025372 LOC101973038 LOC101973038 POLE4 POLE4 RCBTB1 RCBTB1 RPA3 RPA3 ENSSTOP00000027930 ENSSTOP00000027930 RAD51D RAD51D ENSSTOP00000028194 ENSSTOP00000028194 Polk Polk ENSSTOP00000028703 ENSSTOP00000028703 KAT5 KAT5 ENSSTOP00000029771 ENSSTOP00000029771
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
EXD2Exonuclease 3'-5' domain containing 2. (631 aa)
I3LWG0_ICTTRRECA_2 domain-containing protein. (187 aa)
RFC3Replication factor C subunit 3. (339 aa)
Pold3Uncharacterized protein. (467 aa)
Brca1Uncharacterized protein. (353 aa)
I3LWU8_ICTTRUncharacterized protein. (69 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (307 aa)
BARD1BRCA1 associated RING domain 1. (776 aa)
XRCC2X-ray repair cross complementing 2. (278 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (432 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
RAD51CRAD51 paralog C. (360 aa)
MUS81MUS81 structure-specific endonuclease subunit. (567 aa)
RPA2Replication protein A2. (271 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BLMBLM RecQ like helicase. (1414 aa)
I3M6A8_ICTTRUncharacterized protein. (968 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa)
RFC1Replication factor C subunit 1. (1118 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
Rad50Zinc-hook domain-containing protein. (1312 aa)
POLHDNA polymerase eta. (714 aa)
SPIDRScaffold protein involved in DNA repair. (948 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (937 aa)
POLD1DNA polymerase. (1106 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
Rbbp8CtIP_N domain-containing protein. (773 aa)
Rfc4AAA domain-containing protein. (364 aa)
WRNWRN RecQ like helicase. (1448 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (913 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1007 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
Pold4Uncharacterized protein. (107 aa)
RAD51BRAD51 paralog B. (258 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
Palb2PALB2_WD40 domain-containing protein. (384 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
I3MUA8_ICTTRAAA domain-containing protein. (312 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1748 aa)
Slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (274 aa)
RFC2Replication factor C subunit 2. (321 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
LOC101971599Uncharacterized protein. (730 aa)
Pole3CBFD_NFYB_HMF domain-containing protein. (147 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Rfc5AAA domain-containing protein. (340 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
ENSSTOP00000025372CBFD_NFYB_HMF domain-containing protein. (134 aa)
LOC101973038UmuC domain-containing protein. (265 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RPA3Replication protein A3. (121 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa)
ENSSTOP00000028194SAE2 domain-containing protein. (75 aa)
PolkUmuC domain-containing protein. (541 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ENSSTOP00000029771AAA domain-containing protein. (336 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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