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| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (115 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (615 aa) |
| | LOC101973038 | UmuC domain-containing protein. (265 aa) |
| | SIRT6 | Sirtuin 6. (351 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (729 aa) |
| | ENSSTOP00000025372 | CBFD_NFYB_HMF domain-containing protein. (134 aa) |
| | ENSSTOP00000025090 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (125 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa) |
| | CLSPN | Claspin. (1320 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | Kdm4a | Uncharacterized protein. (1064 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RFC1 | Replication factor C subunit 1. (1118 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (420 aa) |
| | Babam1 | BRISC and BRCA1 A complex member 1. (335 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (708 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (566 aa) |
| | I3N0J6_ICTTR | RAP80_UIM domain-containing protein. (166 aa) |
| | RFC2 | Replication factor C subunit 2. (321 aa) |
| | LOC101957469 | Histone H2B type 1-K. (126 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (274 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1748 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC101957760 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101978127 | Histone H4. (103 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1845 aa) |
| | LOC106145261 | Histone H4. (103 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa) |
| | PAXIP1 | PAX interacting protein 1. (1032 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | I3MUA8_ICTTR | AAA domain-containing protein. (312 aa) |
| | I3MU87_ICTTR | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa) |
| | LOC106145260 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2480 aa) |
| | Palb2 | PALB2_WD40 domain-containing protein. (384 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | RAD51B | RAD51 paralog B. (258 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1007 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | TIMELESS | Timeless circadian regulator. (1147 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1057 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (913 aa) |
| | I3MLW0_ICTTR | Uncharacterized protein. (78 aa) |
| | WRN | WRN RecQ like helicase. (1448 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (467 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (406 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | Rfc4 | AAA domain-containing protein. (364 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (472 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (403 aa) |
| | Rbbp8 | CtIP_N domain-containing protein. (773 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | POLD1 | DNA polymerase. (1106 aa) |
| | CHEK2 | Checkpoint kinase 2. (545 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (937 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (948 aa) |
| | POLH | DNA polymerase eta. (714 aa) |
| | Ube2i | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386'; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ATRIP | ATR interacting protein. (793 aa) |
| | POLQ | DNA polymerase theta. (2588 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1312 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (279 aa) |
| | Rps27a | Ubiquitin-like domain-containing protein. (156 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (411 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (611 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (330 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSSTOP00000026845 | Histone H2B; Belongs to the histone H2B family. (101 aa) |
| | ENSSTOP00000027930 | Uncharacterized protein. (173 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa) |
| | ENSSTOP00000028194 | SAE2 domain-containing protein. (75 aa) |
| | Polk | UmuC domain-containing protein. (541 aa) |
| | ENSSTOP00000028703 | Ubiquitin-like domain-containing protein. (122 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSSTOP00000028911 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa) |
| | ENSSTOP00000028952 | Uncharacterized protein. (103 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | LOC101972801 | Histone H4. (103 aa) |
| | ENSSTOP00000029771 | AAA domain-containing protein. (336 aa) |
| | ENSSTOP00000029801 | RING-type domain-containing protein. (191 aa) |
| | ENSSTOP00000029812 | Small ubiquitin-related modifier. (112 aa) |
| | LOC101976763 | Uncharacterized LOC101976763. (103 aa) |
| | H2BC6 | Histone H2B type 1. (126 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | Apbb2 | Uncharacterized protein. (761 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4835 aa) |
| | ENSSTOP00000031366 | Ubiquitin-like domain-containing protein. (95 aa) |
| | Sumo1 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | Pole3 | CBFD_NFYB_HMF domain-containing protein. (147 aa) |
| | LOC101954853 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC106145262 | Histone H4. (103 aa) |
| | LOC101966763 | Ubiquitin-like domain-containing protein. (156 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (301 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | LOC101970966 | Histone domain-containing protein; Belongs to the histone H2B family. (129 aa) |
| | LOC101972712 | Histone H2B type 1. (126 aa) |
| | Rfc5 | AAA domain-containing protein. (340 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | LOC101975357 | Histone H2B type 1. (126 aa) |
| | ENSSTOP00000025041 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (135 aa) |
| | LOC101971599 | Uncharacterized protein. (730 aa) |
| | LOC101962379 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (455 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101967236 | Histone H4. (103 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | Pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | LOC101954827 | Histone domain-containing protein; Belongs to the histone H2B family. (122 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | LOC101976322 | Uncharacterized protein. (604 aa) |
| | KDM4B | Lysine demethylase 4B. (1107 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (631 aa) |
| | I3LWG0_ICTTR | RECA_2 domain-containing protein. (187 aa) |
| | RFC3 | Replication factor C subunit 3. (339 aa) |
| | Pold3 | Uncharacterized protein. (467 aa) |
| | RNF169 | Ring finger protein 169. (550 aa) |
| | Brca1 | Uncharacterized protein. (353 aa) |
| | I3LWU8_ICTTR | Uncharacterized protein. (69 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (307 aa) |
| | LOC101954381 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa) |
| | I3LZW4_ICTTR | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (689 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (776 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (278 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (432 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (529 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (567 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | UBXN1 | UBX domain protein 1. (297 aa) |
| | RPA2 | Replication protein A2. (271 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (422 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (699 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (618 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (551 aa) |
| | BLM | BLM RecQ like helicase. (1414 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | I3M6A8_ICTTR | Uncharacterized protein. (968 aa) |
| | LIG3 | DNA ligase. (1013 aa) |
| | SIRT7 | Sirtuin 7. (339 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (734 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1968 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa) |
