STRINGSTRING
I3MLW0_ICTTR I3MLW0_ICTTR MAPK8 MAPK8 PIAS4 PIAS4 CHEK2 CHEK2 Ube2i Ube2i Rad50 Rad50 Rps27a Rps27a APBB1 APBB1 Babam1 Babam1 ABRAXAS1 ABRAXAS1 TP53BP1 TP53BP1 EYA1 EYA1 EYA2 EYA2 UBA52 UBA52 ATM ATM UBXN1 UBXN1 BARD1 BARD1 I3LZW4_ICTTR I3LZW4_ICTTR LOC101954381 LOC101954381 Brca1 Brca1 RNF169 RNF169 Sumo1 Sumo1 ENSSTOP00000031366 ENSSTOP00000031366 HERC2 HERC2 Apbb2 Apbb2 EYA3 EYA3 H2BC6 H2BC6 LOC101976763 LOC101976763 ENSSTOP00000029812 ENSSTOP00000029812 ENSSTOP00000029801 ENSSTOP00000029801 LOC101972801 LOC101972801 KAT5 KAT5 ENSSTOP00000028911 ENSSTOP00000028911 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000027930 ENSSTOP00000027930 ENSSTOP00000026845 ENSSTOP00000026845 LOC101976322 LOC101976322 KDM4B KDM4B EYA4 EYA4 BAP1 BAP1 ENSSTOP00000025090 ENSSTOP00000025090 ENSSTOP00000025041 ENSSTOP00000025041 LOC101975357 LOC101975357 MRE11 MRE11 LOC101972712 LOC101972712 PPP5C PPP5C KPNA2 KPNA2 H2BU1 H2BU1 LOC101967236 LOC101967236 LOC101954827 LOC101954827 UBE2V2 UBE2V2 Kdm4a Kdm4a H2BC21 H2BC21 LOC101954853 LOC101954853 LOC106145262 LOC106145262 LOC101962379 LOC101962379 TP53 TP53 LOC101966763 LOC101966763 BRCC3 BRCC3 LOC101970966 LOC101970966 I3N0J6_ICTTR I3N0J6_ICTTR LOC101957469 LOC101957469 H2BC1 H2BC1 LOC101957760 LOC101957760 LOC101978127 LOC101978127 LOC106145261 LOC106145261 H2BC5 H2BC5 LOC106145260 LOC106145260 NSD2 NSD2 NBN NBN H2AX H2AX BABAM2 BABAM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3MLW0_ICTTRUncharacterized protein. (78 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIAS4Protein inhibitor of activated STAT 4. (472 aa)
CHEK2Checkpoint kinase 2. (545 aa)
Ube2iSUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386'; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
Rad50Zinc-hook domain-containing protein. (1312 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (708 aa)
Babam1BRISC and BRCA1 A complex member 1. (335 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
TP53BP1Tumor protein p53 binding protein 1. (1968 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (551 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
UBXN1UBX domain protein 1. (297 aa)
BARD1BRCA1 associated RING domain 1. (776 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
Brca1Uncharacterized protein. (353 aa)
RNF169Ring finger protein 169. (550 aa)
Sumo1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4835 aa)
Apbb2Uncharacterized protein. (761 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
H2BC6Histone H2B type 1. (126 aa)
LOC101976763Uncharacterized LOC101976763. (103 aa)
ENSSTOP00000029812Small ubiquitin-related modifier. (112 aa)
ENSSTOP00000029801RING-type domain-containing protein. (191 aa)
LOC101972801Histone H4. (103 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
ENSSTOP00000026845Histone H2B; Belongs to the histone H2B family. (101 aa)
LOC101976322Uncharacterized protein. (604 aa)
KDM4BLysine demethylase 4B. (1107 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (615 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
ENSSTOP00000025090UBIQUITIN_CONJUGAT_2 domain-containing protein. (125 aa)
ENSSTOP00000025041UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (135 aa)
LOC101975357Histone H2B type 1. (126 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
LOC101972712Histone H2B type 1. (126 aa)
PPP5CSerine/threonine-protein phosphatase. (499 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101967236Histone H4. (103 aa)
LOC101954827Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
Kdm4aUncharacterized protein. (1064 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101954853Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC106145262Histone H4. (103 aa)
LOC101962379Histone H2B; Belongs to the histone H2B family. (126 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
LOC101970966Histone domain-containing protein; Belongs to the histone H2B family. (129 aa)
I3N0J6_ICTTRRAP80_UIM domain-containing protein. (166 aa)
LOC101957469Histone H2B type 1-K. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC101957760Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101978127Histone H4. (103 aa)
LOC106145261Histone H4. (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC106145260Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
BABAM2BRISC and BRCA1 A complex member 2. (406 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.