STRINGSTRING
LOC101966763 LOC101966763 LOC101975628 LOC101975628 ENSSTOP00000032378 ENSSTOP00000032378 Sumo1 Sumo1 ENSSTOP00000031366 ENSSTOP00000031366 VWA5B2 VWA5B2 PIAS1 PIAS1 XPC XPC USP45 USP45 ENSSTOP00000029812 ENSSTOP00000029812 ENSSTOP00000028911 ENSSTOP00000028911 ENSSTOP00000028717 ENSSTOP00000028717 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000027334 ENSSTOP00000027334 ERCC2 ERCC2 RPA3 RPA3 ENSSTOP00000025413 ENSSTOP00000025413 ENSSTOP00000025090 ENSSTOP00000025090 ENSSTOP00000025041 ENSSTOP00000025041 Sumo2 Sumo2 GTF2H4 GTF2H4 RAD23B RAD23B Gtf2h2c Gtf2h2c MEIOB MEIOB MNAT1 MNAT1 UBE2V2 UBE2V2 CETN2 CETN2 RAD23A RAD23A GTF2H1 GTF2H1 CCNH CCNH RNF111 RNF111 LOC101954381 LOC101954381 I3LZW4_ICTTR I3LZW4_ICTTR PARP3 PARP3 XPA XPA ERCC1 ERCC1 VWA5A VWA5A GTF2H5 GTF2H5 CUL4A CUL4A RPA2 RPA2 UBA52 UBA52 PIAS3 PIAS3 GTF2H3 GTF2H3 Bivm Bivm LOC101968680 LOC101968680 WDR76 WDR76 CHD1L CHD1L VTCN1 VTCN1 DDB2 DDB2 DDB1 DDB1 I3MBE0_ICTTR I3MBE0_ICTTR VWA5B1 VWA5B1 Rps27a Rps27a Ube2i Ube2i Sumo3 Sumo3 ERCC3 ERCC3 CETN3 CETN3 ERCC4 ERCC4 KCTD2 KCTD2 Rbx1 Rbx1 PARP1 PARP1 NFATC2IP NFATC2IP RPA1 RPA1 CUL4B CUL4B CDK7 CDK7 I3N110_ICTTR I3N110_ICTTR PARP2 PARP2 LOC101970206 LOC101970206
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
LOC101975628Small ubiquitin-related modifier. (85 aa)
ENSSTOP00000032378Rad60-SLD domain-containing protein. (85 aa)
Sumo1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1266 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (811 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (817 aa)
ENSSTOP00000029812Small ubiquitin-related modifier. (112 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
ENSSTOP00000028717RING-type domain-containing protein. (95 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000027334Small ubiquitin-related modifier. (112 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RPA3Replication protein A3. (121 aa)
ENSSTOP00000025413Uncharacterized protein. (72 aa)
ENSSTOP00000025090UBIQUITIN_CONJUGAT_2 domain-containing protein. (125 aa)
ENSSTOP00000025041UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (135 aa)
Sumo2Small ubiquitin-related modifier. (88 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
Gtf2h2cGeneral transcription factor IIH subunit. (395 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
CETN2Centrin 2. (172 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
RNF111Ring finger protein 111. (984 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
PARP3Poly [ADP-ribose] polymerase. (529 aa)
XPAXPA, DNA damage recognition and repair factor. (275 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
VWA5AVon Willebrand factor A domain containing 5A. (799 aa)
GTF2H5General transcription factor IIH subunit 5. (74 aa)
CUL4ACullin 4A; Belongs to the cullin family. (671 aa)
RPA2Replication protein A2. (271 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
BivmUncharacterized protein. (503 aa)
LOC101968680ERCC excision repair 5, endonuclease. (1170 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (623 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (853 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
I3MBE0_ICTTRSmall ubiquitin-related modifier. (111 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1219 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
Ube2iSUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386'; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
Sumo3Small ubiquitin-related modifier. (102 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
CETN3Centrin 3. (167 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
KCTD2Potassium channel tetramerization domain containing 2. (252 aa)
Rbx1RING-type domain-containing protein. (108 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
NFATC2IPNuclear factor of activated T cells 2 interacting protein. (426 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
CUL4BCullin 4B; Belongs to the cullin family. (970 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
I3N110_ICTTRRING-type domain-containing protein. (147 aa)
PARP2Poly [ADP-ribose] polymerase. (566 aa)
LOC101970206Small ubiquitin-related modifier. (93 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.