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| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (631 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (855 aa) |
| | Plk5 | Uncharacterized protein. (608 aa) |
| | Taf9 | Uncharacterized protein. (265 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | ENSSTOP00000031366 | Ubiquitin-like domain-containing protein. (95 aa) |
| | TAF13 | TATA-box binding protein associated factor 13. (124 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | ENSSTOP00000030597 | Uncharacterized protein. (100 aa) |
| | Ly6g5b | Uncharacterized protein. (195 aa) |
| | ENSSTOP00000029771 | AAA domain-containing protein. (336 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSSTOP00000028703 | Ubiquitin-like domain-containing protein. (122 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (584 aa) |
| | ENSSTOP00000028194 | SAE2 domain-containing protein. (75 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | ENSSTOP00000027930 | Uncharacterized protein. (173 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSSTOP00000026345 | Protein kinase domain-containing protein. (386 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (472 aa) |
| | ENSSTOP00000024463 | RING-type domain-containing protein. (209 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | Rfc5 | AAA domain-containing protein. (340 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (561 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1208 aa) |
| | LOC101971599 | Uncharacterized protein. (730 aa) |
| | LOC101966763 | Ubiquitin-like domain-containing protein. (156 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1212 aa) |
| | NUAK2 | NUAK family kinase 2. (631 aa) |
| | NUAK1 | NUAK family kinase 1. (629 aa) |
| | RFC2 | Replication factor C subunit 2. (321 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa) |
| | I3MUQ5_ICTTR | RING-type domain-containing protein. (239 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | I3MUA8_ICTTR | AAA domain-containing protein. (312 aa) |
| | TP53RK | TP53 regulating kinase. (246 aa) |
| | Taf1 | Transcription initiation factor TFIID subunit. (1926 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (325 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1007 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (636 aa) |
| | Mdm2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (787 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1057 aa) |
| | WRN | WRN RecQ like helicase. (1448 aa) |
| | Taf11 | TATA-box binding protein associated factor 11. (211 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (248 aa) |
| | Rfc4 | AAA domain-containing protein. (364 aa) |
| | TAF7 | TATA-box binding protein associated factor 7. (349 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (403 aa) |
| | Aurka | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (363 aa) |
| | Rbbp8 | CtIP_N domain-containing protein. (773 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1060 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | CHEK2 | Checkpoint kinase 2. (545 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (937 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | ATRIP | ATR interacting protein. (793 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (667 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1312 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1214 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (279 aa) |
| | Rps27a | Ubiquitin-like domain-containing protein. (156 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (678 aa) |
| | Csnk2a1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | TBP | TATA-box binding protein. (323 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (420 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (746 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (637 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (646 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1163 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | BLM | BLM RecQ like helicase. (1414 aa) |
| | I3M4Y3_ICTTR | Protein kinase domain-containing protein. (142 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (699 aa) |
| | I3M4T6_ICTTR | Uncharacterized protein. (243 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (239 aa) |
| | RPA2 | Replication protein A2. (271 aa) |
| | Mdm4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | RFC3 | Replication factor C subunit 3. (339 aa) |
| | Brca1 | Uncharacterized protein. (353 aa) |
| | Taf7l | TAFII55_N domain-containing protein. (294 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (930 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (287 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (776 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (432 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (343 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
