STRINGSTRING
PPP2R1A PPP2R1A CCNG1 CCNG1 DAXX DAXX AKT2 AKT2 CCNA1 CCNA1 Mdm4 Mdm4 ATM ATM UBA52 UBA52 USP2 USP2 RICTOR RICTOR CDK3 CDK3 CCNA2 CCNA2 Rps27a Rps27a RNF34 RNF34 PPP2CA PPP2CA AKT3 AKT3 MAPKAP1 MAPKAP1 CHEK2 CHEK2 PDPK1 PDPK1 Mdm2 Mdm2 TXNDC11 TXNDC11 Sgk1 Sgk1 I3MUQ5_ICTTR I3MUQ5_ICTTR LOC101966763 LOC101966763 TP53 TP53 PHF20 PHF20 I3NC46_ICTTR I3NC46_ICTTR ENSSTOP00000024463 ENSSTOP00000024463 RFFL RFFL PPP2R1B PPP2R1B Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 CDK1 CDK1 PPP2R5C PPP2R5C AKT1 AKT1 ENSSTOP00000028703 ENSSTOP00000028703 CDK2 CDK2 MLST8 MLST8 USP7 USP7 ENSSTOP00000031366 ENSSTOP00000031366 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
DAXXDeath domain associated protein. (740 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
Mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1660 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
RNF34Ring finger protein 34. (385 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
CHEK2Checkpoint kinase 2. (545 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
TXNDC11Thioredoxin domain containing 11. (882 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
I3MUQ5_ICTTRRING-type domain-containing protein. (239 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
PHF20PHD finger protein 20. (1013 aa)
I3NC46_ICTTRNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
ENSSTOP00000024463RING-type domain-containing protein. (209 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (396 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1085 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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