STRINGSTRING
Rps27a Rps27a WEE1 WEE1 ANAPC5 ANAPC5 MCM4 MCM4 CABLES1 CABLES1 PSMB1 PSMB1 AKT3 AKT3 PSMC3 PSMC3 Psmd9 Psmd9 POLD1 POLD1 DNA2 DNA2 CCND1 CCND1 RFC3 RFC3 Cks2 Cks2 Psma6 Psma6 CDC16 CDC16 GINS2 GINS2 FZR1 FZR1 ENSSTOP00000028075 ENSSTOP00000028075 STAG1 STAG1 STAG2 STAG2 AKT1 AKT1 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000028717 ENSSTOP00000028717 PSMA4 PSMA4 CDK2 CDK2 Mcm8 Mcm8 ENSSTOP00000029537 ENSSTOP00000029537 ENSSTOP00000029771 ENSSTOP00000029771 ENSSTOP00000030001 ENSSTOP00000030001 ENSSTOP00000030245 ENSSTOP00000030245 SKP1 SKP1 ENSSTOP00000030603 ENSSTOP00000030603 CDK3 CDK3 UBE2D1 UBE2D1 PSMB5 PSMB5 RFC1 RFC1 POLE2 POLE2 PSMA1 PSMA1 CUL1 CUL1 GINS3 GINS3 GMNN GMNN SMC1A SMC1A PSMC2 PSMC2 CDC6 CDC6 UBA52 UBA52 ORC3 ORC3 RPA2 RPA2 CCNE2 CCNE2 Esco1 Esco1 ANAPC1 ANAPC1 ORC5 ORC5 ORC6 ORC6 PSMD10 PSMD10 Pola2 Pola2 CCNA1 CCNA1 PSMB9 PSMB9 FEN1 FEN1 UBE2E1 UBE2E1 AKT2 AKT2 SKP2 SKP2 POLD2 POLD2 TCERG1L TCERG1L PSMB10 PSMB10 PSMB2 PSMB2 PDS5B PDS5B MCM3 MCM3 Cdk4 Cdk4 RB1 RB1 ANAPC16 ANAPC16 CCNH CCNH PSMD4 PSMD4 CDC26 CDC26 ESCO2 ESCO2 Pold3 Pold3 MNAT1 MNAT1 RAD21L1 RAD21L1 Tm4sf19 Tm4sf19 Pole3 Pole3 TM7SF3 TM7SF3 CDCA5 CDCA5 LOC101961074 LOC101961074 PRIM2 PRIM2 PSMB8 PSMB8 LOC101966763 LOC101966763 CDKN1A CDKN1A I3N4N6_ICTTR I3N4N6_ICTTR ORC4 ORC4 GINS4 GINS4 I3N1R8_ICTTR I3N1R8_ICTTR I3N110_ICTTR I3N110_ICTTR RFC2 RFC2 CDK7 CDK7 RPA1 RPA1 ORC2 ORC2 POLE POLE MCM2 MCM2 I3MUA8_ICTTR I3MUA8_ICTTR I3MU87_ICTTR I3MU87_ICTTR PSMB11 PSMB11 ATAD5 ATAD5 Anapc11 Anapc11 CDKN1B CDKN1B CDT1 CDT1 ANAPC4 ANAPC4 PSMA8 PSMA8 Pold4 Pold4 ORC1 ORC1 Rbx1 Rbx1 PSMD14 PSMD14 Psmb6 Psmb6 RCBTB2 RCBTB2 Psmc6 Psmc6 PSMD8 PSMD8 GINS1 GINS1 RAD21 RAD21 PSMB7 PSMB7 MCM6 MCM6 MCM5 MCM5 PSMA3 PSMA3 PSMA2 PSMA2 PSMD7 PSMD7 PSMD5 PSMD5 Rfc4 Rfc4 PSMD6 PSMD6 PSMC4 PSMC4 PSMA7 PSMA7 PDS5A PDS5A UBE2C UBE2C WAPL WAPL SMC3 SMC3 PSMB4 PSMB4 ANAPC7 ANAPC7 CDC23 CDC23 ANAPC10 ANAPC10 PTK6 PTK6 CDC27 CDC27 CCNA2 CCNA2 PSME4 PSME4 Psmc5 Psmc5 MCM7 MCM7 Prim1 Prim1 PSMD1 PSMD1 CCNE1 CCNE1 ENSSTOP00000031366 ENSSTOP00000031366 PSMD12 PSMD12 Psmc1 Psmc1 ENSSTOP00000031690 ENSSTOP00000031690 ANAPC2 ANAPC2 UBE2S UBE2S PSME2 PSME2 PSMD11 PSMD11 PSMA5 PSMA5 RPA3 RPA3 RCBTB1 RCBTB1 LIG1 LIG1 ENSSTOP00000026404 ENSSTOP00000026404 POLE4 POLE4 PSME3 PSME3 PSME1 PSME1 ENSSTOP00000025372 ENSSTOP00000025372 ENSSTOP00000025153 ENSSTOP00000025153 PSMD2 PSMD2 LOC101972090 LOC101972090 CKS1B CKS1B PSMD13 PSMD13 Pola1 Pola1 ENSSTOP00000024401 ENSSTOP00000024401 Rfc5 Rfc5 ENSSTOP00000024305 ENSSTOP00000024305 PSMB3 PSMB3 ENSSTOP00000024190 ENSSTOP00000024190 ANAPC15 ANAPC15 PSMF1 PSMF1 PSMD3 PSMD3 Cdc25b Cdc25b Pcna Pcna MEIOB MEIOB LOC101967492 LOC101967492
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rps27aUbiquitin-like domain-containing protein. (156 aa)
WEE1Wee1-like protein kinase. (645 aa)
ANAPC5Anaphase promoting complex subunit 5. (691 aa)
MCM4DNA helicase; Belongs to the MCM family. (862 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (506 aa)
PSMB1Proteasome subunit beta. (240 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
Psmd9PDZ domain-containing protein. (223 aa)
POLD1DNA polymerase. (1106 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
CCND1Cyclin D1. (250 aa)
RFC3Replication factor C subunit 3. (339 aa)
Cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Psma6Proteasome subunit alpha type. (148 aa)
CDC16Cell division cycle 16. (614 aa)
GINS2GINS complex subunit 2. (141 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
STAG1Stromal antigen 1. (1269 aa)
STAG2Stromal antigen 2. (1268 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000028717RING-type domain-containing protein. (95 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
ENSSTOP00000029537Proteasome subunit beta. (200 aa)
ENSSTOP00000029771AAA domain-containing protein. (336 aa)
ENSSTOP00000030001AAA domain-containing protein. (334 aa)
ENSSTOP00000030245Uncharacterized protein. (174 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSSTOP00000030603UBIQUITIN_CONJUGAT_2 domain-containing protein. (183 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
PSMB5Proteasome subunit beta. (220 aa)
RFC1Replication factor C subunit 1. (1118 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa)
PSMA1Proteasome subunit alpha type. (266 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GINS3GINS complex subunit 3. (216 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ORC3Origin recognition complex subunit 3. (715 aa)
RPA2Replication protein A2. (271 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
Esco1Uncharacterized protein. (338 aa)
ANAPC1Anaphase promoting complex subunit 1. (1891 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
ORC6Origin recognition complex subunit 6. (253 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PSMB9Proteasome subunit beta. (219 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
UBE2E1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
SKP2S-phase kinase associated protein 2. (401 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
TCERG1LTranscription elongation regulator 1 like. (510 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB2Proteasome subunit beta. (201 aa)
PDS5BPDS5 cohesin associated factor B. (1448 aa)
MCM3DNA helicase; Belongs to the MCM family. (807 aa)
Cdk4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
RB1RB transcriptional corepressor 1. (957 aa)
ANAPC16Anaphase promoting complex subunit 16. (122 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
CDC26Cell division cycle 26. (85 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (581 aa)
Pold3Uncharacterized protein. (467 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RAD21L1RAD21 cohesin complex component like 1. (548 aa)
Tm4sf19Uncharacterized protein. (210 aa)
Pole3CBFD_NFYB_HMF domain-containing protein. (147 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
CDCA5Cell division cycle associated 5. (247 aa)
LOC101961074Uncharacterized protein. (295 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (503 aa)
PSMB8Proteasome subunit beta. (276 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
I3N4N6_ICTTRRhodanese domain-containing protein. (465 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
I3N1R8_ICTTRUncharacterized protein. (199 aa)
I3N110_ICTTRRING-type domain-containing protein. (147 aa)
RFC2Replication factor C subunit 2. (321 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
MCM2DNA helicase; Belongs to the MCM family. (724 aa)
I3MUA8_ICTTRAAA domain-containing protein. (312 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
PSMB11Proteasome subunit beta. (293 aa)
ATAD5ATPase family AAA domain containing 5. (1897 aa)
Anapc11RING-type domain-containing protein. (84 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CDT1Chromatin licensing and DNA replication factor 1. (473 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
PSMA8Proteasome subunit alpha type. (257 aa)
Pold4Uncharacterized protein. (107 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa)
Rbx1RING-type domain-containing protein. (108 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
Psmb6Proteasome subunit beta. (239 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
Psmc626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (389 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
GINS1GINS complex subunit 1. (197 aa)
RAD21RAD21 cohesin complex component. (631 aa)
PSMB7Proteasome subunit beta. (277 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
Rfc4AAA domain-containing protein. (364 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
PDS5APDS5 cohesin associated factor A. (1337 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
WAPLWAPL cohesin release factor. (1196 aa)
SMC3Structural maintenance of chromosomes 3. (995 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ANAPC7Anaphase promoting complex subunit 7. (581 aa)
CDC23Cell division cycle 23. (599 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PTK6Tyrosine-protein kinase. (450 aa)
CDC27Cell division cycle 27. (848 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
PSME4Proteasome activator subunit 4. (1840 aa)
Psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (407 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
Psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
ENSSTOP00000031690ANK_REP_REGION domain-containing protein. (189 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (830 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
RPA3Replication protein A3. (121 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LIG1DNA ligase. (922 aa)
ENSSTOP00000026404Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
PSME3Proteasome activator subunit 3. (254 aa)
PSME1Proteasome activator subunit 1. (249 aa)
ENSSTOP00000025372CBFD_NFYB_HMF domain-containing protein. (134 aa)
ENSSTOP00000025153PROTEASOME_ALPHA_1 domain-containing protein. (87 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
LOC101972090AAA domain-containing protein; Belongs to the AAA ATPase family. (372 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
Pola1DNA polymerase. (767 aa)
ENSSTOP00000024401Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (68 aa)
Rfc5AAA domain-containing protein. (340 aa)
ENSSTOP00000024305Uncharacterized protein. (210 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSSTOP00000024190Protein kinase domain-containing protein. (266 aa)
ANAPC15Anaphase promoting complex subunit 15. (151 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
Cdc25bRhodanese domain-containing protein. (572 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
LOC101967492Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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