STRINGSTRING
COP1 COP1 PSME4 PSME4 Psmc5 Psmc5 PSMD1 PSMD1 Rps27a Rps27a CCNE1 CCNE1 PSMB1 PSMB1 PSMC3 PSMC3 Psmd9 Psmd9 CHEK2 CHEK2 Psma6 Psma6 PSMB4 PSMB4 PSMA7 PSMA7 PSMC4 PSMC4 PSMD6 PSMD6 PSMD5 PSMD5 PSMD7 PSMD7 PSMA2 PSMA2 PSMA3 PSMA3 PSMB7 PSMB7 PSMD8 PSMD8 Psmc6 Psmc6 Mdm2 Mdm2 Psmb6 Psmb6 PSMD14 PSMD14 PSMA8 PSMA8 CDKN1B CDKN1B ZNF385A ZNF385A PSMB11 PSMB11 I3MUQ5_ICTTR I3MUQ5_ICTTR I3N1R8_ICTTR I3N1R8_ICTTR CDKN1A CDKN1A LOC101966763 LOC101966763 TP53 TP53 PSMB8 PSMB8 PHF20 PHF20 ZNF385C ZNF385C PSMD3 PSMD3 PSMF1 PSMF1 PSMB3 PSMB3 ENSSTOP00000024305 ENSSTOP00000024305 ENSSTOP00000024463 ENSSTOP00000024463 PSMD13 PSMD13 LOC101972090 LOC101972090 PSMD2 PSMD2 ENSSTOP00000025153 ENSSTOP00000025153 PSME1 PSME1 PSME3 PSME3 PSMA5 PSMA5 PSMD11 PSMD11 PSME2 PSME2 ENSSTOP00000028075 ENSSTOP00000028075 PSMD4 PSMD4 PSMB2 PSMB2 PSMB10 PSMB10 PSMB9 PSMB9 CCNA1 CCNA1 PSMD10 PSMD10 Mdm4 Mdm4 CCNE2 CCNE2 ATM ATM UBA52 UBA52 PSMC2 PSMC2 PSMA1 PSMA1 PSMB5 PSMB5 CDK3 CDK3 CCNA2 CCNA2 ENSSTOP00000028703 ENSSTOP00000028703 PSMA4 PSMA4 CDK2 CDK2 ENSSTOP00000029537 ENSSTOP00000029537 ENSSTOP00000030001 ENSSTOP00000030001 ENSSTOP00000031366 ENSSTOP00000031366 PSMD12 PSMD12 Psmc1 Psmc1 ENSSTOP00000031690 ENSSTOP00000031690 ZNF385B ZNF385B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COP1COP1 E3 ubiquitin ligase. (641 aa)
PSME4Proteasome activator subunit 4. (1840 aa)
Psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PSMB1Proteasome subunit beta. (240 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
Psmd9PDZ domain-containing protein. (223 aa)
CHEK2Checkpoint kinase 2. (545 aa)
Psma6Proteasome subunit alpha type. (148 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
Psmc626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (389 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
Psmb6Proteasome subunit beta. (239 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMA8Proteasome subunit alpha type. (257 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ZNF385AZinc finger protein 385A. (385 aa)
PSMB11Proteasome subunit beta. (293 aa)
I3MUQ5_ICTTRRING-type domain-containing protein. (239 aa)
I3N1R8_ICTTRUncharacterized protein. (199 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
PSMB8Proteasome subunit beta. (276 aa)
PHF20PHD finger protein 20. (1013 aa)
ZNF385CZinc finger protein 385C. (418 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSSTOP00000024305Uncharacterized protein. (210 aa)
ENSSTOP00000024463RING-type domain-containing protein. (209 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
LOC101972090AAA domain-containing protein; Belongs to the AAA ATPase family. (372 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
ENSSTOP00000025153PROTEASOME_ALPHA_1 domain-containing protein. (87 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME3Proteasome activator subunit 3. (254 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB9Proteasome subunit beta. (219 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
Mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
PSMA1Proteasome subunit alpha type. (266 aa)
PSMB5Proteasome subunit beta. (220 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSSTOP00000029537Proteasome subunit beta. (200 aa)
ENSSTOP00000030001AAA domain-containing protein. (334 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
Psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
ENSSTOP00000031690ANK_REP_REGION domain-containing protein. (189 aa)
ZNF385BZinc finger protein 385B. (486 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.