STRINGSTRING
Akap13 Akap13 ARHGEF10L ARHGEF10L TAB3 TAB3 BIRC7 BIRC7 FGD4 FGD4 ARHGEF6 ARHGEF6 SOS1 SOS1 ENSSTOP00000030003 ENSSTOP00000030003 NGF NGF LOC101961455 LOC101961455 PLEKHG5 PLEKHG5 ENSSTOP00000031129 ENSSTOP00000031129 ENSSTOP00000031310 ENSSTOP00000031310 ENSSTOP00000031366 ENSSTOP00000031366 MCF2 MCF2 Ube2d3 Ube2d3 MAP3K7 MAP3K7 SQSTM1 SQSTM1 VAV3 VAV3 LOC101966763 LOC101966763 ARHGEF4 ARHGEF4 ARHGEF3 ARHGEF3 RTN4 RTN4 WDR31 WDR31 ARHGEF2 ARHGEF2 TIAM2 TIAM2 Arhgef25 Arhgef25 RIPK1 RIPK1 GNA13 GNA13 Rnf31 Rnf31 TAB1 TAB1 AATF AATF UBE2D4 UBE2D4 SHARPIN SHARPIN CLIP4 CLIP4 NFATC4 NFATC4 TAX1BP1 TAX1BP1 XIAP XIAP ARHGEF1 ARHGEF1 Casp3 Casp3 ADAM17 ADAM17 Rhoa Rhoa UBA52 UBA52 ARHGEF39 ARHGEF39 CASP2 CASP2 Ywhae Ywhae SPPL2A SPPL2A Tgm3 Tgm3 USP2 USP2 OMG OMG ARHGEF15 ARHGEF15 KALRN KALRN BIRC3 BIRC3 Birc2 Birc2 IKBKB IKBKB TIAM1 TIAM1 APH1A APH1A TNFSF10 TNFSF10 LOC101973389 LOC101973389 MAPKAPK2 MAPKAPK2 USP21 USP21 RAC1 RAC1 BAG4 BAG4 RACK1 RACK1 UBE2D1 UBE2D1 TRAF6 TRAF6 NET1 NET1 NFKBIA NFKBIA Faslg Faslg NGFR NGFR TNFAIP3 TNFAIP3 NSMAF NSMAF TBK1 TBK1 BAD BAD ARHGEF37 ARHGEF37 NCSTN NCSTN TGM6 TGM6 Map3k20 Map3k20 CLIP3 CLIP3 Rps27a Rps27a LOC101963830 LOC101963830 Mag Mag TNFRSF1A TNFRSF1A FGD3 FGD3 CYLD CYLD MCF2L2 MCF2L2 SESTD1 SESTD1 VAV1 VAV1 ULK1 ULK1 USP4 USP4 CASP8 CASP8 TRADD TRADD NFKB1 NFKB1 TRAF2 TRAF2 TMEM198 TMEM198 MAPK8 MAPK8 OTULINL OTULINL MYD88 MYD88 SMPD3 SMPD3 ARHGEF17 ARHGEF17 OTULIN OTULIN ARHGEF40 ARHGEF40 RIPK2 RIPK2 ARHGDIA ARHGDIA ARHGEF12 ARHGEF12 FGD2 FGD2 APH1B APH1B PRDM4 PRDM4 Ube2l3 Ube2l3 CHUK CHUK LOC101976087 LOC101976087 Naip Naip STUB1 STUB1 TAB2 TAB2 FGD1 FGD1 SPATA2 SPATA2 ARHGEF16 ARHGEF16 I3MW74_ICTTR I3MW74_ICTTR Ect2 Ect2 RBCK1 RBCK1 SPPL2C SPPL2C ARHGEF26 ARHGEF26 LOC101959922 LOC101959922 LOC101959358 LOC101959358 LINGO1 LINGO1 LINGO2 LINGO2 ECT2L ECT2L CCDC71L CCDC71L ARHGEF5 ARHGEF5 ARHGEF19 ARHGEF19 ARHGEF10 ARHGEF10 OTUD7B OTUD7B MADD MADD NGEF NGEF PLEKHG2 PLEKHG2 ITSN1 ITSN1 LOC101955860 LOC101955860 CASP10 CASP10 TRAF1 TRAF1 VAV2 VAV2 ARHGEF11 ARHGEF11 ARHGEF38 ARHGEF38 BCL2L11 BCL2L11 I3NGQ5_ICTTR I3NGQ5_ICTTR RTN4R RTN4R ARHGEF33 ARHGEF33 Ikbke Ikbke PSEN2 PSEN2 FADD FADD ARHGEF9 ARHGEF9 ULK2 ULK2 MCF2L MCF2L CFLAR CFLAR IRAK1 IRAK1 PSEN1 PSEN1 ENSSTOP00000025973 ENSSTOP00000025973 Bex3 Bex3 SPPL2B SPPL2B ENSSTOP00000026209 ENSSTOP00000026209 PSENEN PSENEN ITGB3BP ITGB3BP IKBKG IKBKG TRIO TRIO ABR ABR ARHGEF7 ARHGEF7 UBE2D2 UBE2D2 SMPD2 SMPD2 ENSSTOP00000028703 ENSSTOP00000028703
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akap13Uncharacterized protein. (1423 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1275 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
BIRC7Baculoviral IAP repeat containing 7. (304 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (939 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (778 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (305 aa)
LOC101961455Uncharacterized protein. (334 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1053 aa)
ENSSTOP00000031129Uncharacterized protein. (71 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
MCF2MCF.2 cell line derived transforming sequence. (1096 aa)
Ube2d3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SQSTM1Sequestosome 1. (440 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (630 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (532 aa)
RTN4Reticulon. (1177 aa)
WDR31WD repeat domain 31. (367 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (869 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1661 aa)
Arhgef25Uncharacterized protein. (619 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
GNA13G protein subunit alpha 13. (306 aa)
Rnf31Uncharacterized protein. (1071 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
AATFApoptosis antagonizing transcription factor. (506 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (144 aa)
SHARPINSHANK associated RH domain interactor. (382 aa)
CLIP4CAP-Gly domain containing linker protein family member 4. (527 aa)
NFATC4Nuclear factor of activated T cells 4. (890 aa)
TAX1BP1Tax1 binding protein 1. (777 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (972 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ADAM17ADAM metallopeptidase domain 17. (811 aa)
RhoaRas homolog family member A. (193 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (448 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
SPPL2ASignal peptide peptidase like 2A. (502 aa)
Tgm3TGc domain-containing protein. (697 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (849 aa)
KALRNKalirin RhoGEF kinase. (2951 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
Birc2Uncharacterized protein. (611 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1567 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)
LOC101973389Uncharacterized protein. (182 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (567 aa)
RAC1Rac family small GTPase 1. (211 aa)
BAG4BCL2 associated athanogene 4. (324 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NET1Neuroepithelial cell transforming 1. (595 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
NGFRNerve growth factor receptor. (428 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (920 aa)
TBK1TANK binding kinase 1. (729 aa)
BADBCL2 associated agonist of cell death. (208 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (672 aa)
NCSTNNicastrin. (709 aa)
TGM6Transglutaminase 6. (706 aa)
Map3k20Uncharacterized protein. (800 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
LOC101963830Uncharacterized protein. (1013 aa)
MagUncharacterized protein. (64 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (725 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1115 aa)
SESTD1SEC14 and spectrin domain containing 1. (696 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
TRADDTNFRSF1A associated via death domain. (302 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TMEM198Transmembrane protein 198. (360 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (284 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2060 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (311 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1516 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (204 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1518 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (643 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (290 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
Ube2l3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
LOC101976087DUF4203 domain-containing protein. (351 aa)
NaipNACHT domain-containing protein. (1405 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (937 aa)
SPATA2Spermatogenesis associated 2. (509 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (704 aa)
I3MW74_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
Ect2Uncharacterized protein. (188 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (536 aa)
SPPL2CSignal peptide peptidase like 2C. (677 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (851 aa)
LOC101959922Uncharacterized protein. (442 aa)
LOC101959358Uncharacterized protein. (193 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
ECT2LEpithelial cell transforming 2 like. (853 aa)
CCDC71LUncharacterized protein. (176 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1570 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (800 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (933 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
MADDMAP kinase activating death domain. (1597 aa)
NGEFNeuronal guanine nucleotide exchange factor. (707 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1390 aa)
ITSN1Intersectin 1. (1655 aa)
LOC101955860CCHC NOA-type domain-containing protein. (505 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
TRAF1TNF receptor-associated factor. (415 aa)
VAV2Vav guanine nucleotide exchange factor 2. (745 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1494 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (772 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
I3NGQ5_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RTN4RReticulon 4 receptor. (473 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (850 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (523 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1127 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ENSSTOP0000002597314_3_3 domain-containing protein. (119 aa)
Bex3Uncharacterized protein. (102 aa)
SPPL2BSignal peptide peptidase like 2B. (590 aa)
ENSSTOP00000026209UBIQUITIN_CONJUGAT_2 domain-containing protein. (89 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (180 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3069 aa)
ABRABR activator of RhoGEF and GTPase. (871 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (713 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (143 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (419 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (20%) [HD]