28 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1331 aa)
	MGAM2	Maltase-glucoamylase 2 (putative). (1816 aa)
	KLF10	Kruppel like factor 10. (480 aa)
	LOC101973687	Alpha-amylase. (511 aa)
	LOC101974615	Alpha-amylase. (511 aa)
	RSC1A1	Regulator of solute carriers 1. (629 aa)
	CEL	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)
	GUCA2B	Guanylate cyclase activator 2B. (111 aa)
	LOC101973966	Alpha-amylase. (511 aa)
	GUCY2C	Guanylate cyclase. (1062 aa)
	GUCA2A	Guanylate cyclase activator 2A. (115 aa)
	Clps	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. (111 aa)
	ENSSTOP00000030752	P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (902 aa)
	ENSSTOP00000032621	Uncharacterized protein. (81 aa)
	SI	Sucrase-isomaltase. (1629 aa)
	LCT	Lactase. (1928 aa)
	TREH	Trehalase. (579 aa)
	CHIT1	Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (469 aa)
	SLC2A5	Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (481 aa)
	PNLIPRP1	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
	PIR	Pirin; Belongs to the pirin family. (291 aa)
	SLC5A1	Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (663 aa)
	CHIA	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family. (306 aa)
	PNLIP	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius. (465 aa)
	DDI1	DNA damage inducible 1 homolog 1. (406 aa)
	MGAM	Maltase-glucoamylase. (1489 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEL	Clps	ENSSTOP00000020482	ENSSTOP00000021080	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	0.897
CEL	PNLIP	ENSSTOP00000020482	ENSSTOP00000002036	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.982
CEL	PNLIPRP1	ENSSTOP00000020482	ENSSTOP00000007943	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.960
CEL	PNLIPRP2	ENSSTOP00000020482	ENSSTOP00000007959	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.922
CHIA	CHIT1	ENSSTOP00000004975	ENSSTOP00000013500	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	0.843
CHIA	ENSSTOP00000030752	ENSSTOP00000004975	ENSSTOP00000030752	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family.	0.406
CHIA	MGAM	ENSSTOP00000004975	ENSSTOP00000003004	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	Maltase-glucoamylase.	0.406
CHIA	MGAM2	ENSSTOP00000004975	ENSSTOP00000015340	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	Maltase-glucoamylase 2 (putative).	0.406
CHIA	SI	ENSSTOP00000004975	ENSSTOP00000012189	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	Sucrase-isomaltase.	0.406
CHIT1	CHIA	ENSSTOP00000013500	ENSSTOP00000004975	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family.	0.843
CHIT1	ENSSTOP00000030752	ENSSTOP00000013500	ENSSTOP00000030752	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family.	0.406
CHIT1	MGAM	ENSSTOP00000013500	ENSSTOP00000003004	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	Maltase-glucoamylase.	0.406
CHIT1	MGAM2	ENSSTOP00000013500	ENSSTOP00000015340	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	Maltase-glucoamylase 2 (putative).	0.406
CHIT1	SI	ENSSTOP00000013500	ENSSTOP00000012189	Chitinase 1; Belongs to the glycosyl hydrolase 18 family.	Sucrase-isomaltase.	0.406
Clps	CEL	ENSSTOP00000021080	ENSSTOP00000020482	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.897
Clps	ENSSTOP00000032621	ENSSTOP00000021080	ENSSTOP00000032621	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Uncharacterized protein.	0.430
Clps	KLF10	ENSSTOP00000021080	ENSSTOP00000015582	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Kruppel like factor 10.	0.430
Clps	PNLIP	ENSSTOP00000021080	ENSSTOP00000002036	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius.	0.996
Clps	PNLIPRP1	ENSSTOP00000021080	ENSSTOP00000007943	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.990
Clps	PNLIPRP2	ENSSTOP00000021080	ENSSTOP00000007959	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.975